| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20004438 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20045653 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20051482 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44030090 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44020674 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44023481 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44010925 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44049507 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC7A1 |
|---|---|
| DrugBank ID | DB00123 |
| Drug Name | Lysine |
| Target ID | BE0000212 |
| UniProt ID | P30825 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 14523001; 17042743; 9614060 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Fernandez J, Lopez AB, Wang C, Mishra R, Zhou L, Yaman I, Snider MD, Hatzoglou M: Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress. J Biol Chem. 2003 Dec 12;278(50):50000-9. Epub 2003 Sep 30.@@Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, Hatzoglou M: A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J. 2007 Feb 15;402(1):163-73.@@Nicholson B, Sawamura T, Masaki T, MacLeod CL: Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines. J Biol Chem. 1998 Jun 12;273(24):14663-6. |
| Groups | Approved; Nutraceutical |
| Direct Classification | L-alpha-amino acids |
| SMILES | NCCCC[C@H](N)C(O)=O |
| Pathways | Multiple Carboxylase Deficiency, Neonatal or Early Onset Form; Biotin Metabolism; Glutaric Aciduria Type I; 2-Aminoadipic 2-Oxoadipic Aciduria; Hyperlysinemia II or Saccharopinuria; Hyperlysinemia I, Familial; Saccharopinuria/Hyperlysinemia II; Carnitine Synthesis; Lysine Degradation; Biotinidase Deficiency; Pyridoxine Dependency with Seizures |
| PharmGKB | PA450280 |
| ChEMBL | CHEMBL8085 |
