| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10031985 | HBV | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS30002251 | HIV | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS30036965 | HIV | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS20051793 | HPV | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS20068074 | HPV | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS44041650 | HTLV-1 | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
| TVIS44035189 | HTLV-1 | ENSG00000100596.8 | protein_coding | SPTLC2 | No | No | 9517 | O15270 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SPTLC2 |
|---|---|
| DrugBank ID | DB00114 |
| Drug Name | Pyridoxal phosphate |
| Target ID | BE0000660 |
| UniProt ID | O15270 |
| Regulation Type | cofactor |
| PubMed IDs | 12782147; 11726713; 11781309; 11279212; 11171191 |
| Citations | Hanada K: Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30.@@Tamura K, Mitsuhashi N, Hara-Nishimura I, Imai H: Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Plant Cell Physiol. 2001 Nov;42(11):1274-81.@@Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem. 2002 Mar 22;277(12):10194-200. Epub 2002 Jan 7.@@Ikushiro H, Hayashi H, Kagamiyama H: A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. J Biol Chem. 2001 May 25;276(21):18249-56. Epub 2001 Mar 12.@@Tamura K, Nishiura H, Mori J, Imai H: Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana. Biochem Soc Trans. 2000 Dec;28(6):745-7. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Pyridoxals and derivatives |
| SMILES | CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O |
| Pathways | Histidinemia; 3-Methylglutaconic Aciduria Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); beta-Ketothiolase Deficiency; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Argininosuccinic Aciduria; Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Porphyrin Metabolism; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; Glutaric Aciduria Type I; Propanoate Metabolism; Taurine and Hypotaurine Metabolism; Catecholamine Biosynthesis; Glycine and Serine Metabolism; Carnitine Synthesis; Tyrosinemia Type 3 (TYRO3); Selenoamino Acid Metabolism; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Saccharopinuria/Hyperlysinemia II; Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; Starch and Sucrose Metabolism; Globoid Cell Leukodystrophy; Ammonia Recycling |
| PharmGKB | PA164749650 |
| ChEMBL | CHEMBL82202 |
