| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10015083 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10015084 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10015085 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10015086 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028976 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028977 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028978 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028979 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028980 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
| TVIS10028981 | HBV | ENSG00000172296.13 | protein_coding | SPTLC3 | No | No | 55304 | Q9NUV7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SPTLC3 |
|---|---|
| DrugBank ID | DB00114 |
| Drug Name | Pyridoxal phosphate |
| Target ID | BE0002172 |
| UniProt ID | Q9NUV7 |
| Regulation Type | cofactor |
| PubMed IDs | 22616865; 12782147; 19648650; 19416851 |
| Citations | Lowther J, Naismith JH, Dunn TM, Campopiano DJ: Structural, mechanistic and regulatory studies of serine palmitoyltransferase. Biochem Soc Trans. 2012 Jun 1;40(3):547-54. doi: 10.1042/BST20110769.@@Hanada K: Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30.@@Hornemann T, Penno A, Rutti MF, Ernst D, Kivrak-Pfiffner F, Rohrer L, von Eckardstein A: The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. J Biol Chem. 2009 Sep 25;284(39):26322-30. doi: 10.1074/jbc.M109.023192. Epub 2009 Aug 1.@@Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F, Brown RH Jr, Harmon JM, Dunn TM: Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8186-91. doi: 10.1073/pnas.0811269106. Epub 2009 May 5. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Pyridoxals and derivatives |
| SMILES | CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O |
| Pathways | Histidinemia; 3-Methylglutaconic Aciduria Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); beta-Ketothiolase Deficiency; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Argininosuccinic Aciduria; Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Porphyrin Metabolism; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; Glutaric Aciduria Type I; Propanoate Metabolism; Taurine and Hypotaurine Metabolism; Catecholamine Biosynthesis; Glycine and Serine Metabolism; Carnitine Synthesis; Tyrosinemia Type 3 (TYRO3); Selenoamino Acid Metabolism; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Saccharopinuria/Hyperlysinemia II; Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; Starch and Sucrose Metabolism; Globoid Cell Leukodystrophy; Ammonia Recycling |
| PharmGKB | PA164749650 |
| ChEMBL | CHEMBL82202 |
