| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30016613 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30016614 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30021692 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069809 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069810 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069811 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SQLE |
|---|---|
| DrugBank ID | DB00735 |
| Drug Name | Naftifine |
| Target ID | BE0000577 |
| UniProt ID | Q14534 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 8834895; 1951574; 12499173; 3877503; 1287164 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Favre B, Ryder NS: Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.@@Vanden Bossche H, Marichal P: Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.@@Mukherjee PK, Leidich SD, Isham N, Leitner I, Ryder NS, Ghannoum MA: Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother. 2003 Jan;47(1):82-6.@@Ryder NS, Dupont MC: Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J. 1985 Sep 15;230(3):765-70.@@Ryder NS, Frank I: Interaction of terbinafine with human serum and serum proteins. J Med Vet Mycol. 1992;30(6):451-60. |
| Groups | Approved |
| Direct Classification | Naphthalenes |
| SMILES | CN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA164748617 |
| ChEMBL | CHEMBL626 |
