| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30043888 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043889 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043890 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043891 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043892 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30021375 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30021376 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043893 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043894 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
| TVIS30043895 | HIV | ENSG00000173757.11 | protein_coding | STAT5B | Yes | No | 6777 | P51692 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | STAT5B |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0000891 |
| UniProt ID | P51692 |
| Regulation Type | inhibitor |
| PubMed IDs | 17020995; 17431118 |
| Citations | Fiskus W, Pranpat M, Balasis M, Bali P, Estrella V, Kumaraswamy S, Rao R, Rocha K, Herger B, Lee F, Richon V, Bhalla K: Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78.@@Nam S, Williams A, Vultur A, List A, Bhalla K, Smith D, Lee FY, Jove R: Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol Cancer Ther. 2007 Apr;6(4):1400-5. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
