| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10031922 | HBV | ENSG00000196664.5 | protein_coding | TLR7 | No | No | 51284 | B2R9N9 Q9NYK1 |
| TVIS20038474 | HPV | ENSG00000196664.5 | protein_coding | TLR7 | No | No | 51284 | B2R9N9 Q9NYK1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TLR7 |
|---|---|
| DrugBank ID | DB00724 |
| Drug Name | Imiquimod |
| Target ID | BE0000155 |
| UniProt ID | Q9NYK1 |
| Regulation Type | agonist |
| PubMed IDs | 12470615; 12527213; 14616353; 15068862; 15072849; 11752352 |
| Citations | Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE, Oesterich JL, Gorden KB, Qiu X, McKane SW, Noelle RJ, Miller RL, Kedl RM, Fitzgerald-Bocarsly P, Tomai MA, Vasilakos JP: Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol. 2002 Jul-Aug;218(1-2):74-86.@@Akira S, Hemmi H: Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett. 2003 Jan 22;85(2):85-95.@@Dummer R, Urosevic M, Kempf W, Hoek K, Hafner J, Burg G: Imiquimod in basal cell carcinoma: how does it work? Br J Dermatol. 2003 Nov;149 Suppl 66:57-8.@@Otero M, Calarota SA, Felber B, Laddy D, Pavlakis G, Boyer JD, Weiner DB: Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model. Vaccine. 2004 Apr 16;22(13-14):1782-90.@@Ambach A, Bonnekoh B, Nguyen M, Schon MP, Gollnick H: Imiquimod, a Toll-like receptor-7 agonist, induces perforin in cytotoxic T lymphocytes in vitro. Mol Immunol. 2004 Apr;40(18):1307-14.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Imidazoquinolines |
| SMILES | CC(C)CN1C=NC2=C1C1=C(C=CC=C1)N=C2N |
| Pathways | |
| PharmGKB | PA449972 |
| ChEMBL | CHEMBL1282 |
