| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30080108 | HIV | ENSG00000129167.11 | protein_coding | TPH1 | No | No | 7166 | P17752 |
| TVIS44046707 | HTLV-1 | ENSG00000129167.11 | protein_coding | TPH1 | No | No | 7166 | P17752 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TPH1 |
|---|---|
| DrugBank ID | DB00360 |
| Drug Name | Sapropterin |
| Target ID | BE0000121 |
| UniProt ID | P17752 |
| Regulation Type | cofactor |
| PubMed IDs | 10381000; 11472242; 12414107; 15223360; 2665179 |
| Citations | Chamas F, Serova L, Sabban EL: Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neurosci Lett. 1999 Jun 4;267(3):157-60.@@Martinez A, Knappskog PM, Haavik J: A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Curr Med Chem. 2001 Jul;8(9):1077-91.@@Ikemoto K, Suzuki T, Ichinose H, Ohye T, Nishimura A, Nishi K, Nagatsu I, Nagatsu T: Localization of sepiapterin reductase in the human brain. Brain Res. 2002 Nov 8;954(2):237-46.@@Serova LI, Maharjan S, Huang A, Sun D, Kaley G, Sabban EL: Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain Res. 2004 Jul 23;1015(1-2):1-8.@@Haavik J: [From butterflies to neurobiology and the diagnosis of AIDS. The 100th anniversary of the discovery of pteridines]. Tidsskr Nor Laegeforen. 1989 Jun 30;109(19-21):1986-9. |
| Groups | Approved; Investigational |
| Direct Classification | Biopterins and derivatives |
| SMILES | [H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)O |
| Pathways | Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Hyperornithinemia with Gyrate Atrophy (HOGA); Sepiapterin Reductase Deficiency; DOPA-Responsive Dystonia; Alkaptonuria; Tyrosine Metabolism; Pterine Biosynthesis; Disulfiram Action Pathway; Hyperprolinemia Type II; Hyperphenylalaninemia Due to DHPR-Deficiency; Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps); Hyperphenylalaniemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency; L-Arginine:Glycine Amidinotransferase Deficiency; Tyrosinemia Type I; Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]; Tryptophan Metabolism; Doxorubicin Metabolism Pathway; Segawa Syndrome; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Prolidase Deficiency (PD); Hawkinsinuria; Dopamine beta-Hydroxylase Deficiency; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Ornithine Aminotransferase Deficiency (OAT Deficiency); Hyperprolinemia Type I; Monoamine Oxidase-A Deficiency (MAO-A); Tyrosinemia, Transient, of the Newborn; Nitric Oxide Signaling Pathway; Arginine and Proline Metabolism; Prolinemia Type II |
| PharmGKB | PA161990676 |
| ChEMBL | CHEMBL1201774 |
