| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10046896 | HBV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20007279 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20005425 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20042386 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20040873 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS20023692 | HPV | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS44015773 | HTLV-1 | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
| TVIS44008995 | HTLV-1 | ENSG00000115705.22 | protein_coding | TPO | No | No | 7173 | P07202 Q502Y3 Q6P534 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TPO |
|---|---|
| DrugBank ID | DB00389 |
| Drug Name | Carbimazole |
| Target ID | BE0000507 |
| UniProt ID | P07202 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 17042691; 6706930; 1278093; 7952157; 7528484; 476986; 18055877 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Guilhem I, Massart C, Poirier JY, Maugendre D: Differential evolution of thyroid peroxidase and thyrotropin receptor antibodies in Graves' disease: thyroid peroxidase antibody activity reverts to pretreatment level after carbimazole withdrawal. Thyroid. 2006 Oct;16(10):1041-5.@@Magnusson RP, Taurog A, Dorris ML: Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem. 1984 Jan 10;259(1):197-205.@@Taurog A: The mechanism of action of the thioureylene antithyroid drugs. Endocrinology. 1976 Apr;98(4):1031-46.@@Perrild H, Gruters-Kieslich A, Feldt-Rasmussen U, Grant D, Martino E, Kayser L, Delange F: Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73.@@Orgiazzi J, Millot L: [Theoretical aspects of the treatment with antithyroid drugs]. Ann Endocrinol (Paris). 1994;55(1):1-5.@@Nakashima T, Taurog A: Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf). 1979 Jun;10(6):637-48.@@Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer CI, Loop T, Geiger KK, Pahl HL, Pannen BH: Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha. J Pharmacol Exp Ther. 2008 Mar;324(3):1037-44. Epub 2007 Nov 30. |
| Groups | Approved; Investigational |
| Direct Classification | Carbonylimidazoles |
| SMILES | CCOC(=O)N1C=CN(C)C1=S |
| Pathways | |
| PharmGKB | PA164742970 |
| ChEMBL | CHEMBL508102 |
