| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30015903 | HIV | ENSG00000144481.17 | protein_coding | TRPM8 | No | No | 79054 | Q7Z2W7 W8DTH1 |
| TVIS20055467 | HPV | ENSG00000144481.17 | protein_coding | TRPM8 | No | No | 79054 | Q7Z2W7 W8DTH1 |
| TVIS44015844 | HTLV-1 | ENSG00000144481.17 | protein_coding | TRPM8 | No | No | 79054 | Q7Z2W7 W8DTH1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TRPM8 |
|---|---|
| DrugBank ID | DB00825 |
| Drug Name | Levomenthol |
| Target ID | BE0001186 |
| UniProt ID | Q7Z2W7 |
| Regulation Type | inducer |
| PubMed IDs | 12654248; 14757700; 15046718; 15190109; 15311065; 7529306; 11752352 |
| Citations | Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29.@@Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R: Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. Epub 2004 Feb 2.@@Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57.@@Andersson DA, Chase HW, Bevan S: TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 2004 Jun 9;24(23):5364-9.@@Stein RJ, Santos S, Nagatomi J, Hayashi Y, Minnery BS, Xavier M, Patel AS, Nelson JB, Futrell WJ, Yoshimura N, Chancellor MB, De Miguel F: Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J Urol. 2004 Sep;172(3):1175-8.@@Eccles R: Menthol and related cooling compounds. J Pharm Pharmacol. 1994 Aug;46(8):618-30.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved |
| Direct Classification | Menthane monoterpenoids |
| SMILES | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O |
| Pathways | |
| PharmGKB | PA164776605 |
| ChEMBL | CHEMBL470670 |
