| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10026838 | HBV | ENSG00000139131.13 | protein_coding | YARS2 | No | No | 51067 | Q9Y2Z4 |
| TVIS30032472 | HIV | ENSG00000139131.13 | protein_coding | YARS2 | No | No | 51067 | Q9Y2Z4 |
| TVIS20066795 | HPV | ENSG00000139131.13 | protein_coding | YARS2 | No | No | 51067 | Q9Y2Z4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | YARS2 |
|---|---|
| DrugBank ID | DB00135 |
| Drug Name | Tyrosine |
| Target ID | BE0000363 |
| UniProt ID | Q9Y2Z4 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 15840835; 12097643; 12754495 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Zhang Y, Wang L, Schultz PG, Wilson IA: Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Sci. 2005 May;14(5):1340-9.@@Kiga D, Sakamoto K, Kodama K, Kigawa T, Matsuda T, Yabuki T, Shirouzu M, Harada Y, Nakayama H, Takio K, Hasegawa Y, Endo Y, Hirao I, Yokoyama S: An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9715-20. Epub 2002 Jul 3.@@Kobayashi T, Nureki O, Ishitani R, Yaremchuk A, Tukalo M, Cusack S, Sakamoto K, Yokoyama S: Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol. 2003 Jun;10(6):425-32. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Tyrosine and derivatives |
| SMILES | N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
| Pathways | Dopamine beta-Hydroxylase Deficiency; Tyrosine Metabolism; Thyroid Hormone Synthesis; Disulfiram Action Pathway; Aromatic L-Aminoacid Decarboxylase Deficiency; Monoamine Oxidase-A Deficiency (MAO-A); Catecholamine Biosynthesis; Phenylketonuria; Tyrosinemia, Transient, of the Newborn; Tyrosinemia Type 3 (TYRO3); Hawkinsinuria; Tyrosinemia Type 2 (or Richner-Hanhart Syndrome); Phenylalanine and Tyrosine Metabolism; Tyrosinemia Type I; Alkaptonuria; Tyrosine Hydroxylase Deficiency |
| PharmGKB | PA451822 |
| ChEMBL | CHEMBL925 |
