| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30070814 | HIV | ENSG00000165272.16 | protein_coding | AQP3 | No | No | 360 | Q92482 |
| TVIS44032421 | HTLV-1 | ENSG00000165272.16 | protein_coding | AQP3 | No | No | 360 | Q92482 |
| TVIS44017074 | HTLV-1 | ENSG00000165272.16 | protein_coding | AQP3 | No | No | 360 | Q92482 |
| TVIS44001054 | HTLV-1 | ENSG00000165272.16 | protein_coding | AQP3 | No | No | 360 | Q92482 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AQP3 |
|---|---|
| DrugBank ID | DB09020 |
| Drug Name | Bisacodyl |
| Target ID | BE0009664 |
| UniProt ID | Q92482 |
| Regulation Type | negative modulator |
| PubMed IDs | 21868635; 6249558; 6253843 |
| Citations | Ikarashi N, Baba K, Ushiki T, Kon R, Mimura A, Toda T, Ishii M, Ochiai W, Sugiyama K: The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G887-95. doi: 10.1152/ajpgi.00286.2011. Epub 2011 Aug 25.@@Rachmilewitz D, Karmeli F, Okon E: Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine. Dig Dis Sci. 1980 Aug;25(8):602-8. doi: 10.1007/BF01318874.@@Schreiner J, Nell G, Loeschke K: Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1980 Sep;313(3):249-55. doi: 10.1007/BF00505741. |
| Groups | Approved |
| Direct Classification | Diphenylmethanes |
| SMILES | CC(=O)OC1=CC=C(C=C1)C(C1=CC=C(OC(C)=O)C=C1)C1=CC=CC=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL942 |
