| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10042493 | HBV | ENSG00000177606.9 | protein_coding | JUN | Yes | No | 3725 | P05412 |
| TVIS44000585 | HTLV-1 | ENSG00000177606.9 | protein_coding | JUN | Yes | No | 3725 | P05412 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JUN |
|---|---|
| DrugBank ID | DB00570 |
| Drug Name | Vinblastine |
| Target ID | BE0001040 |
| UniProt ID | P05412 |
| Regulation Type | other/unknown |
| PubMed IDs | 12907245; 15498923; 16111654; 16555127; 17126817 |
| Citations | Brantley-Finley C, Lyle CS, Du L, Goodwin ME, Hall T, Szwedo D, Kaushal GP, Chambers TC: The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochem Pharmacol. 2003 Aug 1;66(3):459-69.@@Bene A, Kurten RC, Chambers TC: Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic Acids Res. 2004 Oct 21;32(19):e142.@@Obey TB, Lyle CS, Chambers TC: Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine. Biochem Biophys Res Commun. 2005 Oct 7;335(4):1179-84.@@Martinez-Campa C, Casado P, Rodriguez R, Zuazua P, Garcia-Pedrero JM, Lazo PS, Ramos S: Effect of vinca alkaloids on ERalpha levels and estradiol-induced responses in MCF-7 cells. Breast Cancer Res Treat. 2006 Jul;98(1):81-9. Epub 2006 Mar 23.@@Duan L, Sterba K, Kolomeichuk S, Kim H, Brown PH, Chambers TC: Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol. 2007 Feb 15;73(4):481-90. Epub 2006 Oct 29. |
| Groups | Approved |
| Direct Classification | Vinca alkaloids |
| SMILES | [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]2(O)C(=O)OC)[C@@]13[H])[C@]1(C[C@@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=C2C=CC=C1)C(=O)OC |
| Pathways | Vinblastine Action Pathway |
| PharmGKB | PA451877 |
| ChEMBL | CHEMBL159 |
