| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10042493 | HBV | ENSG00000177606.9 | protein_coding | JUN | Yes | No | 3725 | P05412 |
| TVIS44000585 | HTLV-1 | ENSG00000177606.9 | protein_coding | JUN | Yes | No | 3725 | P05412 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JUN |
|---|---|
| DrugBank ID | DB01169 |
| Drug Name | Arsenic trioxide |
| Target ID | BE0001040 |
| UniProt ID | P05412 |
| Regulation Type | inducer |
| PubMed IDs | 12075113; 12426127; 12475910; 12547826; 12637567 |
| Citations | Muscarella DE, Bloom SE: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol Sci. 2002 Jul;68(1):82-92.@@Dong Z: The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ Health Perspect. 2002 Oct;110 Suppl 5:757-9.@@Drobna Z, Jaspers I, Thomas DJ, Styblo M: Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J. 2003 Jan;17(1):67-9. Epub 2002 Nov 15.@@Li J, Gorospe M, Barnes J, Liu Y: Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J Biol Chem. 2003 Apr 11;278(15):13183-91. Epub 2003 Jan 23.@@Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11. |
| Groups | Approved; Investigational |
| Direct Classification | Metalloid oxides |
| SMILES | O=[As]O[As]=O |
| Pathways | |
| PharmGKB | PA448486 |
| ChEMBL | CHEMBL1200978 |
