| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30005408 | HIV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS30025485 | HIV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS20047103 | HPV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS44030910 | HTLV-1 | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NTRK1 |
|---|---|
| DrugBank ID | DB00619 |
| Drug Name | Imatinib |
| Target ID | BE0001039 |
| UniProt ID | P04629 |
| Regulation Type | antagonist |
| PubMed IDs | 15832750; 16052979; 16782438; 17579194; 17582306 |
| Citations | Catani M, De Milito R, Simi M: [New orientations in the management of advanced, metastatic gastrointestinal stromal tumors (GIST): combination of surgery and systemic therapy with imatinib in a case of primary gastric location]. Chir Ital. 2005 Jan-Feb;57(1):127-33.@@Kovacs M, Nagy P, Pak G, Feher J: [Gastrointestinal stromal tumors (GISTs): clinical and pathological features]. Orv Hetil. 2005 Jun 26;146(26):1375-81.@@de Groot JW, Plaza Menacho I, Schepers H, Drenth-Diephuis LJ, Osinga J, Plukker JT, Links TP, Eggen BJ, Hofstra RM: Cellular effects of imatinib on medullary thyroid cancer cells harboring multiple endocrine neoplasia Type 2A and 2B associated RET mutations. Surgery. 2006 Jun;139(6):806-14.@@de Groot JW, Zonnenberg BA, van Ufford-Mannesse PQ, de Vries MM, Links TP, Lips CJ, Voest EE: A phase II trial of imatinib therapy for metastatic medullary thyroid carcinoma. J Clin Endocrinol Metab. 2007 Sep;92(9):3466-9. Epub 2007 Jun 19.@@Delbaldo C: [Pharmacokinetic-pharmacodynamics relationships of imatinib (Glivec)]. Therapie. 2007 Mar-Apr;62(2):87-90. Epub 2007 Jun 21. |
| Groups | Approved |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1 |
| Pathways | Imatinib Inhibition of BCR-ABL |
| PharmGKB | PA10804 |
| ChEMBL | CHEMBL941 |
