| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30005408 | HIV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS30025485 | HIV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS20047103 | HPV | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
| TVIS44030910 | HTLV-1 | ENSG00000198400.14 | protein_coding | NTRK1 | Yes | No | 4914 | P04629 X5DR71 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NTRK1 |
|---|---|
| DrugBank ID | DB00321 |
| Drug Name | Amitriptyline |
| Target ID | BE0001039 |
| UniProt ID | P04629 |
| Regulation Type | agonist |
| PubMed IDs | 19549602; 27149473; 21666748 |
| Citations | Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. doi: 10.1016/j.chembiol.2009.05.010.@@Zheng X, Chen F, Zheng T, Huang F, Chen J, Tu W: Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons. Medicine (Baltimore). 2016 May;95(18):e3559. doi: 10.1097/MD.0000000000003559.@@Rantamaki T, Vesa L, Antila H, Di Lieto A, Tammela P, Schmitt A, Lesch KP, Rios M, Castren E: Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One. 2011;6(6):e20567. doi: 10.1371/journal.pone.0020567. Epub 2011 Jun 7. |
| Groups | Approved |
| Direct Classification | Dibenzocycloheptenes |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA448385 |
| ChEMBL | CHEMBL629 |
