| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30002701 | HIV | ENSG00000126351.13 | protein_coding | THRA | No | No | 7067 | P10827 Q6FH41 |
| TVIS30086145 | HIV | ENSG00000126351.13 | protein_coding | THRA | No | No | 7067 | P10827 Q6FH41 |
| TVIS30043746 | HIV | ENSG00000126351.13 | protein_coding | THRA | No | No | 7067 | P10827 Q6FH41 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | THRA |
|---|---|
| DrugBank ID | DB00451 |
| Drug Name | Levothyroxine |
| Target ID | BE0000687 |
| UniProt ID | P10827 |
| Regulation Type | agonist |
| PubMed IDs | 17016423; 17139284; 17315033; 20615127; 11752352; 20051527 |
| Citations | Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59.@@Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. doi: 10.1089/thy.2009.0389.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Cheng SY, Leonard JL, Davis PJ: Molecular aspects of thyroid hormone actions. Endocr Rev. 2010 Apr;31(2):139-70. doi: 10.1210/er.2009-0007. Epub 2010 Jan 5. |
| Groups | Approved |
| Direct Classification | Phenylalanine and derivatives |
| SMILES | N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O |
| Pathways | Thyroid Hormone Synthesis |
| PharmGKB | PA450221 |
| ChEMBL | CHEMBL1624 |
