| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30086172 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30084988 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055183 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055184 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055185 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055186 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS30055187 | HIV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS20038778 | HPV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS20023449 | HPV | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
| TVIS44030081 | HTLV-1 | ENSG00000186716.21 | protein_coding | BCR | Yes | No | 613 | P11274 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCR |
|---|---|
| DrugBank ID | DB08901 |
| Drug Name | Ponatinib |
| Target ID | BE0004743 |
| UniProt ID | P11274 |
| Regulation Type | inhibitor |
| PubMed IDs | 23409026 |
| Citations | Iqbal Z, Aleem A, Iqbal M, Naqvi MI, Gill A, Taj AS, Qayyum A, ur-Rehman N, Khalid AM, Shah IH, Khalid M, Haq R, Khan M, Baig SM, Jamil A, Abbas MN, Absar M, Mahmood A, Rasool M, Akhtar T: Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era. PLoS One. 2013;8(2):e55717. doi: 10.1371/journal.pone.0055717. Epub 2013 Feb 8. |
| Groups | Approved; Investigational |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1 |
| Pathways | Ponatinib Inhibition of BCR-ABL |
| PharmGKB | PA165980594 |
| ChEMBL | CHEMBL1171837 |
