| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10040202 | HBV | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
| TVIS10040086 | HBV | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
| TVIS30010849 | HIV | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
| TVIS20037373 | HPV | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
| TVIS20039601 | HPV | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
| TVIS44012431 | HTLV-1 | ENSG00000157404.17 | protein_coding | KIT | Yes | No | 3815 | P10721 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KIT |
|---|---|
| DrugBank ID | DB01268 |
| Drug Name | Sunitinib |
| Target ID | BE0000453 |
| UniProt ID | P10721 |
| Regulation Type | inhibitor |
| PubMed IDs | 12748309; 12873999; 17545799; 14753710; 17367763; 11752352 |
| Citations | Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003 May;2(5):471-8.@@Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 15;63(14):4009-16.@@Joensuu H: Second line therapies for the treatment of gastrointestinal stromal tumor. Curr Opin Oncol. 2007 Jul;19(4):353-8.@@Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94.@@Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Indolines |
| SMILES | CCN(CC)CCNC(=O)C1=C(C)NC(C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C |
| Pathways | |
| PharmGKB | PA162372840 |
| ChEMBL | CHEMBL535 |
