| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10033962 | HBV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
| TVIS10043496 | HBV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
| TVIS30071315 | HIV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
| TVIS30071316 | HIV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
| TVIS20019429 | HPV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
| TVIS20063546 | HPV | ENSG00000090054.16 | protein_coding | SPTLC1 | No | No | 10558 | O15269 Q6NUL7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SPTLC1 |
|---|---|
| DrugBank ID | DB00114 |
| Drug Name | Pyridoxal phosphate |
| Target ID | BE0000441 |
| UniProt ID | O15269 |
| Regulation Type | cofactor |
| PubMed IDs | 12782147; 11781309; 11279212 |
| Citations | Hanada K: Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30.@@Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem. 2002 Mar 22;277(12):10194-200. Epub 2002 Jan 7.@@Ikushiro H, Hayashi H, Kagamiyama H: A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. J Biol Chem. 2001 May 25;276(21):18249-56. Epub 2001 Mar 12. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Pyridoxals and derivatives |
| SMILES | CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O |
| Pathways | Histidinemia; 3-Methylglutaconic Aciduria Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); beta-Ketothiolase Deficiency; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Argininosuccinic Aciduria; Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Porphyrin Metabolism; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; Glutaric Aciduria Type I; Propanoate Metabolism; Taurine and Hypotaurine Metabolism; Catecholamine Biosynthesis; Glycine and Serine Metabolism; Carnitine Synthesis; Tyrosinemia Type 3 (TYRO3); Selenoamino Acid Metabolism; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Saccharopinuria/Hyperlysinemia II; Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; Starch and Sucrose Metabolism; Globoid Cell Leukodystrophy; Ammonia Recycling |
| PharmGKB | PA164749650 |
| ChEMBL | CHEMBL82202 |
