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  hiF-T cell

Overall Designsingle cell RNA-seq profiles from 52 unfractionated hiF-T cells after 10 days of reprogramming
SummaryInduced pluripotency is a promising avenue for disease modeling and therapy, but the molecular principles underlying this process, particularly in human cells, remain poorly understood due to donor-to-donor variability and intercellular heterogeneity. Here we constructed and characterized a clonal, inducible human reprogramming system that provides a reliable source of cells at any stage of the process. This system enabled integrative transcriptional and epigenomic analysis across the human reprogramming timeline at high resolution. We observed distinct waves of gene network activation, including the ordered re-activation of broad developmental regulators followed by early embryonic patterning genes and culminating in the emergence of a signature reminiscent of pre-implantation stages. Moreover, complementary functional analyses allowed us to identify and validate novel regulators of the reprogramming process. Altogether, this study sheds light on the molecular underpinnings of induced pluripotency in human cells and provides a robust cell platform for further studies.
Dataset viewGSE69292
PMID26186193

Samples in hiF-T cell

Displaying 11-20 of 52 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE69292GSM1697195Illumina HiSeq 2500Homo sapiensq19_0hiF-T cell
GSE69292GSM1697178Illumina HiSeq 2500Homo sapiensq2_0hiF-T cell
GSE69292GSM1697196Illumina HiSeq 2500Homo sapiensq20_0hiF-T cell
GSE69292GSM1697197Illumina HiSeq 2500Homo sapiensq21_0hiF-T cell
GSE69292GSM1697198Illumina HiSeq 2500Homo sapiensq22_0hiF-T cell
GSE69292GSM1697199Illumina HiSeq 2500Homo sapiensq23_0hiF-T cell
GSE69292GSM1697200Illumina HiSeq 2500Homo sapiensq24_0hiF-T cell
GSE69292GSM1697201Illumina HiSeq 2500Homo sapiensq25_0hiF-T cell
GSE69292GSM1697202Illumina HiSeq 2500Homo sapiensq26_0hiF-T cell
GSE69292GSM1697203Illumina HiSeq 2500Homo sapiensq27_0hiF-T cell

Gene rank in hiF-T cell

Displaying 11-20 of 19345 results.
Rank orderGene SymbolEnsembl ID
11RPS25ENSG00000118181
12RPL17ENSG00000265681
13MTRNR2L1ENSG00000256618
14RPS3AENSG00000145425
15MIFENSG00000240972
16RPL3ENSG00000100316
17GAPDHENSG00000111640
18RPS12ENSG00000112306
19RPS14ENSG00000164587
20RPL9ENSG00000163682