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  glioblastoma [Pro]

Overall DesignOperative specimens from five glioblastoma patients (MGH26, MGH28, MGH29, MGH30, MGH31) were acutely dissociated, depleted for CD45+ inflammatory cells and then sorted as single cells (576 samples). Population controls for each tumor were isolated by sorting 2000-10000 cells and processed in parallel (5 population control samples). Single cells from two established cell lines, GBM6 and GBM8, were also sorted as single cells (192 samples).
SummaryWe report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, MGH28, MGH31) cultured under serum free (GSC) and differentiated (DGC) conditions. This dataset highlights intratumoral heterogeneity with regards to the expression of de novo derived transcriptional modules and established subtype classifiers.
Dataset viewGSE57872
PMID24925914

Samples in glioblastoma [Pro]

Displaying 1-10 of 88 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE57872GSM1395400Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A02glioblastoma [Pro]
GSE57872GSM1395405Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A07glioblastoma [Pro]
GSE57872GSM1395406Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A08glioblastoma [Pro]
GSE57872GSM1395407Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A09glioblastoma [Pro]
GSE57872GSM1395410Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_A12glioblastoma [Pro]
GSE57872GSM1395412Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_B02glioblastoma [Pro]
GSE57872GSM1395415Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_B05glioblastoma [Pro]
GSE57872GSM1395422Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_B12glioblastoma [Pro]
GSE57872GSM1395437Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_D03glioblastoma [Pro]
GSE57872GSM1395451Illumina HiSeq 2500Homo sapiensSingle cell mRNA-seq_MGH26_E05glioblastoma [Pro]

Gene rank in glioblastoma [Pro]