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  Cell line KBM7, derived from a patient with chronic myeloid leukemia

Overall DesignIn this dataset, single-cell mRNA sequencing results from 96 single KBM7 cells have been deposited
SummaryMammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large Lamina Associated Domains (LADs). We report a method to map NL contacts genome-wide in single human cells. Analysis of ~400 maps reveals a core architecture of gene-poor LADs that contact the NL with high cell-to-cell consistency, interspersed by LADs with more variable NL interactions. The variable contacts are more sensitive to a change in genome ploidy than the consistent contacts. Single-cell maps indicate that NL contacts involve multivalent interactions over hundreds of kilobases. Moreover, we observe extensive intra-chromosomal coordination of NL contacts, even over tens of megabases. Such coordinated loci exhibit preferential interactions as detected by Hi-C. Finally, single-cell gene expression and chromatin accessibility analysis shows that loci with consistent NL contacts are expressed at lower levels and are more consistently inaccessible than loci with lower contact frequencies. These results highlight fundamental principles of single cell chromatin organization.
Dataset viewGSE68596
PMID26365489

Samples in Cell line KBM7, derived from a patient with chronic myeloid leukemia

Displaying 21-30 of 96 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE68596GSM1676569.20Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.21Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.22Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.23Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.24Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.25Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.26Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.27Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.28Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.29Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia

Gene rank in Cell line KBM7, derived from a patient with chronic myeloid leukemia

Displaying 71-80 of 13608 results.
Rank orderGene SymbolEnsembl ID
71RPL6ENSG00000089009
72RPL29ENSG00000162244
73RPL7AENSG00000148303
74TMSB4X__chrX
75RPS13ENSG00000110700
76RPL13ENSG00000167526
77RPS15AENSG00000134419
78RPL9ENSG00000163682
79RPL5ENSG00000122406
80RPL21ENSG00000122026