Loading
scRNASeqDB
Home » Search by Cell » Cell View

Cell View

Cell Information

  Cell line KBM7, derived from a patient with chronic myeloid leukemia

Overall DesignIn this dataset, single-cell mRNA sequencing results from 96 single KBM7 cells have been deposited
SummaryMammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large Lamina Associated Domains (LADs). We report a method to map NL contacts genome-wide in single human cells. Analysis of ~400 maps reveals a core architecture of gene-poor LADs that contact the NL with high cell-to-cell consistency, interspersed by LADs with more variable NL interactions. The variable contacts are more sensitive to a change in genome ploidy than the consistent contacts. Single-cell maps indicate that NL contacts involve multivalent interactions over hundreds of kilobases. Moreover, we observe extensive intra-chromosomal coordination of NL contacts, even over tens of megabases. Such coordinated loci exhibit preferential interactions as detected by Hi-C. Finally, single-cell gene expression and chromatin accessibility analysis shows that loci with consistent NL contacts are expressed at lower levels and are more consistently inaccessible than loci with lower contact frequencies. These results highlight fundamental principles of single cell chromatin organization.
Dataset viewGSE68596
PMID26365489

Samples in Cell line KBM7, derived from a patient with chronic myeloid leukemia

Displaying 1-10 of 96 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE68596GSM1676569.96Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.1Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.2Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.3Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.4Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.5Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.6Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.7Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.8Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia
GSE68596GSM1676569.9Illumina HiSeq 2500Homo sapiensSingle cell mRNA sequencing data from KMB7 cellsCell line KBM7, derived from a patient with chronic myeloid leukemia

Gene rank in Cell line KBM7, derived from a patient with chronic myeloid leukemia

Displaying 13591-13600 of 13608 results.
Rank orderGene SymbolEnsembl ID
13591LOC283335
13592LOC440896
13593FAM26EENSG00000178033
13594BGN__chrX
13595FUT9ENSG00000172461
13596HCN1ENSG00000164588
13597GAL3ST4ENSG00000197093
13598SEC14L3ENSG00000100012
13599LINC00439
13600STON1ENSG00000243244