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  Cerebral Cortex GW19.5

Overall Design16 Bulk Tissue Samples from GW13-23; 226 Single Cells from GW19.5-23.5
SummaryLong non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and diseasee. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expression and function of lncRNAs in the developing human brain. Here, we deeply profiled lncRNAs from polyadenylated and total RNA obtained from human neocortex at different stages of development and integrated this resource to analyze the transcriptomes of single cells. While lncRNAs were generally detected at low levels in whole tissues, single cell transcriptomics revealed that many lncRNAs are abundantly expressed in individual cells and are cell type-specific. Furthermore, we used CRISRPi to show that LOC646329, a lncRNA enriched in radial glia but detected at low abundance in tissues, regulates cell proliferation. The discrete and abundant expression of lncRNAs among individual cells has important implications for both their biological function and utility for distinguishing neural cell types.
Dataset viewGSE71315

Samples in Cerebral Cortex GW19.5

Displaying 11-20 of 26 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE71315GSM1832493Illumina HiSeq 2500Homo sapiensS44.D10Cerebral Cortex GW19.5
GSE71315GSM1832494Illumina HiSeq 2500Homo sapiensS44.D5Cerebral Cortex GW19.5
GSE71315GSM1832495Illumina HiSeq 2500Homo sapiensS44.D8Cerebral Cortex GW19.5
GSE71315GSM1832496Illumina HiSeq 2500Homo sapiensS44.D9Cerebral Cortex GW19.5
GSE71315GSM1832497Illumina HiSeq 2500Homo sapiensS44.E10Cerebral Cortex GW19.5
GSE71315GSM1832498Illumina HiSeq 2500Homo sapiensS44.F10Cerebral Cortex GW19.5
GSE71315GSM1832499Illumina HiSeq 2500Homo sapiensS44.F6Cerebral Cortex GW19.5
GSE71315GSM1832500Illumina HiSeq 2500Homo sapiensS44.F9Cerebral Cortex GW19.5
GSE71315GSM1832501Illumina HiSeq 2500Homo sapiensS44.G10Cerebral Cortex GW19.5
GSE71315GSM1832502Illumina HiSeq 2500Homo sapiensS44.G5Cerebral Cortex GW19.5

Gene rank in Cerebral Cortex GW19.5

Displaying 1-10 of 12884 results.
Rank orderGene SymbolEnsembl ID