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Cell Information

  Cerebral Cortex GW23.5

Overall Design16 Bulk Tissue Samples from GW13-23; 226 Single Cells from GW19.5-23.5
SummaryLong non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and diseasee. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expression and function of lncRNAs in the developing human brain. Here, we deeply profiled lncRNAs from polyadenylated and total RNA obtained from human neocortex at different stages of development and integrated this resource to analyze the transcriptomes of single cells. While lncRNAs were generally detected at low levels in whole tissues, single cell transcriptomics revealed that many lncRNAs are abundantly expressed in individual cells and are cell type-specific. Furthermore, we used CRISRPi to show that LOC646329, a lncRNA enriched in radial glia but detected at low abundance in tissues, regulates cell proliferation. The discrete and abundant expression of lncRNAs among individual cells has important implications for both their biological function and utility for distinguishing neural cell types.
Dataset viewGSE71315

Samples in Cerebral Cortex GW23.5

Displaying 1-10 of 77 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE71315GSM1832509Illumina HiSeq 2500Homo sapiensS46.A1Cerebral Cortex GW23.5
GSE71315GSM1832510Illumina HiSeq 2500Homo sapiensS46.A10Cerebral Cortex GW23.5
GSE71315GSM1832511Illumina HiSeq 2500Homo sapiensS46.A11Cerebral Cortex GW23.5
GSE71315GSM1832512Illumina HiSeq 2500Homo sapiensS46.A12Cerebral Cortex GW23.5
GSE71315GSM1832513Illumina HiSeq 2500Homo sapiensS46.A2Cerebral Cortex GW23.5
GSE71315GSM1832514Illumina HiSeq 2500Homo sapiensS46.A4Cerebral Cortex GW23.5
GSE71315GSM1832515Illumina HiSeq 2500Homo sapiensS46.A5Cerebral Cortex GW23.5
GSE71315GSM1832516Illumina HiSeq 2500Homo sapiensS46.A6Cerebral Cortex GW23.5
GSE71315GSM1832517Illumina HiSeq 2500Homo sapiensS46.A7Cerebral Cortex GW23.5
GSE71315GSM1832518Illumina HiSeq 2500Homo sapiensS46.A8Cerebral Cortex GW23.5

Gene rank in Cerebral Cortex GW23.5

Displaying 1-10 of 12884 results.
Rank orderGene SymbolEnsembl ID