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  circulating pancreas tumor cell

Overall DesignTo achieve a deep RNA sequencing profile of CTCs at the single cell level, we applied a novel inertial focusing-enhanced device, the CTC-iChip, which allows high efficiency negative depletion of normal blood cells, leaving unattached CTCs in solution where they can be selected and analyzed as single cells (Pubmed ID 23552373). CTCs were then subjected to single cell RNA-sequencing (Pubmed ID 20203668).
SummaryCirculating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To determine the relevance of ECM protein expression to human disease, CTCs were isolated from the blood of metastatic PDAC patients and subjected to single cell RNA-sequencing. Analysis of 7 pancreatic CTCs from 3 patients revealed that the majority expressed keratins defining their epithelial origin. A total of 13 of 60 extracellular protein genes enriched in mouse CTCs (see GEO GSE51372) were expressed at high levels (>100 rpm) in at least one human pancreatic CTC. Human SPARC was the only gene found at high levels in all human pancreatic CTCs.
Dataset viewGSE60407
PMID25242334

Samples in circulating pancreas tumor cell

Displaying 1-7 of 7 results.
SeriesSampleInstrumentOrganismTitleCell Source
GSE60407GSM1478319AB 5500xl Genetic AnalyzerHomo sapiensHP1_2circulating pancreas tumor cell
GSE60407GSM1478320AB 5500xl Genetic AnalyzerHomo sapiensHP1_3circulating pancreas tumor cell
GSE60407GSM1478321AB 5500xl Genetic AnalyzerHomo sapiensHP2_2circulating pancreas tumor cell
GSE60407GSM1478322AB 5500xl Genetic AnalyzerHomo sapiensHP2_3circulating pancreas tumor cell
GSE60407GSM1478323AB 5500xl Genetic AnalyzerHomo sapiensHP2_4circulating pancreas tumor cell
GSE60407GSM1478324AB 5500xl Genetic AnalyzerHomo sapiensHP2_5circulating pancreas tumor cell
GSE60407GSM1478325AB 5500xl Genetic AnalyzerHomo sapiensHP3_1circulating pancreas tumor cell

Gene rank in circulating pancreas tumor cell

Displaying 11501-11510 of 11561 results.
Rank orderGene SymbolEnsembl ID
11501ST13P4ENSG00000232150
11502STX2ENSG00000111450
11503STX7ENSG00000079950
11504SUGT1P1
11505SULT1B1ENSG00000173597
11506SUV39H1ENSG00000101945
11507SYNPO2LENSG00000166317
11508TACO1ENSG00000136463
11509TAF1AENSG00000143498
11510TAF1BENSG00000115750