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Gene View

General Information

ARHGEF6[ENSG00000129675]

SynonymsCOOL2;Cool-2;MRX46;PIXA;alpha-PIX;alphaPIX
DescriptionRac/Cdc42 guanine nucleotide exchange factor 6
ChromosomeXq26.3
Database ReferenceMIM:300267 HGNC:685 HPRD:02226 Vega:OTTHUMG00000022518 
See relatedTHE HUMAN PROTEIN ATLAS
DatasetGSE67980

Gene Rank

Gene Expression

 

Displaying 1-8 of 8 results.
ARHGEF6 expression in each cell groupMinimum Value (Read count)Median Value (Read count)Maximum Value (Read count)
candidate PCa CTC CRPC004,083
candidate PCa CTC CSPC003,648
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A)00330
lineage-confirmed PCa CTC CRPC progressed on enzalutamide (Group B)001
lineage-confirmed PCa CTC CSPC enzalutamide-naive (Group A)000
PCa cell line00125
white blood cell CRPC00.51
white blood cell healthy04454
Displaying 1-20 of 28 results.
Comparing ARHGEF6 expression between groupsFDR
PCa cell line VS white blood cell CRPCNS
PCa cell line VS white blood cell healthyNS
candidate PCa CTC CRPC VS PCa cell line0.0473386714260625
candidate PCa CTC CRPC VS candidate PCa CTC CSPCNS
candidate PCa CTC CRPC VS lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A)NS
candidate PCa CTC CRPC VS lineage-confirmed PCa CTC CRPC progressed on enzalutamide (Group B)4.59793796096699e-07
candidate PCa CTC CRPC VS lineage-confirmed PCa CTC CSPC enzalutamide-naive (Group A)NS
candidate PCa CTC CRPC VS white blood cell CRPCNS
candidate PCa CTC CRPC VS white blood cell healthyNS
candidate PCa CTC CSPC VS PCa cell line0.00642200472068092
candidate PCa CTC CSPC VS lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A)NS
candidate PCa CTC CSPC VS lineage-confirmed PCa CTC CRPC progressed on enzalutamide (Group B)9.41776209074279e-09
candidate PCa CTC CSPC VS lineage-confirmed PCa CTC CSPC enzalutamide-naive (Group A)NS
candidate PCa CTC CSPC VS white blood cell CRPCNS
candidate PCa CTC CSPC VS white blood cell healthyNS
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A) VS PCa cell lineNS
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A) VS lineage-confirmed PCa CTC CRPC progressed on enzalutamide (Group B)0.00143142963105414
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A) VS lineage-confirmed PCa CTC CSPC enzalutamide-naive (Group A)NS
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A) VS white blood cell CRPCNS
lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A) VS white blood cell healthyNS
NS represents no significant differential expression between two groups was detected by using the BPSC method.

Top 100 positive and negative correlated genes for ARHGEF6

Top correlated genes were calculated by using Spearman rank correlation. Enrichment analysis can be performed on DAVID server using its API, while alternative links are also provided.

KEGG GO Others   

 candidate PCa CTC CRPC[33]
 candidate PCa CTC CSPC[12]
 lineage-confirmed PCa CTC CRPC enzalutamide-naive (Group A)[37]
 lineage-confirmed PCa CTC CRPC progressed on enzalutamide (Group B)[36]
 lineage-confirmed PCa CTC CSPC enzalutamide-naive (Group A)[4]
 PCa cell line[30]
 white blood cell CRPC[2]
 white blood cell healthy[3]