| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 6093 |
Name | ROCK1 |
Synonym | P160ROCK|ROCK-I;Rho-associated, coiled-coil containing protein kinase 1;ROCK1;Rho-associated, coiled-coil containing protein kinase 1 |
Definition | Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I |
Position | 18q11.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | [The effect of breviscapine on the pulmonary arterial pressure and the expression of Rho-kinase in pulmonary arterioles of hypoxic rats]. |
PAH | Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. |
PAH | Role of the RhoA/Rho-kinase pathway in the regulation of pulmonary vasoconstrictor function. |
PAH | Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27. |
PAH | "On the other hand, both Wnt/planar cell polarity (PCP) signaling and its downstream Rho/ROCK signaling were found alone to be activated in IPAH and not in our model". |
PH | Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. |
PH | Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27. |
| More detail of all Rat literatures about ROCK1 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | thrombin signaling and protease-activated receptors;PID BioCarta;100082 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | Apoptotic cleavage of cellular proteins;PID Reactome;500270 |
Pathway | Signaling events mediated by PRL;PID Curated;200006 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase;PID BioCarta;100100 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Noncanonical Wnt signaling pathway;PID Curated;200016 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | rho cell motility signaling pathway;PID BioCarta;100041 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | Cytoskeletal regulation by Rho GTPase;PANTHER;P00016 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Scleroderma;FunDO |
Disease | Ischemia;FunDO |
Disease | Common cold;FunDO |
Disease | Systemic scleroderma;FunDO |
Disease | Embryoma;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Hyperglycemia;FunDO |
Disease | Pancreas cancer;FunDO |
Disease | Subarachnoid hemorrhage;FunDO |
Disease | Stroke;FunDO |
Disease | Breast cancer;FunDO |
Disease | Colon cancer;FunDO |
Disease | Liver cancer;FunDO |
Disease | Neoplasm metastasis;FunDO |
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External Links |
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Links to Entrez Gene | 6093 |
Links to all GeneRIF Items | 6093 |
Links to iHOP | 6093 |
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Sequence Information |
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Nucleotide Sequence |
>6093 : length: 4065 atgtcgactggggacagttttgagactcgatttgaaaaaatggacaacctgctgcgggat cccaaatcggaagtgaattcggattgtttgctggatggattggatgctttggtatatgat ttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaa gacacaataaataaaatcagagatttacgaatgaaagctgaagattatgaagtagtgaag gtgattggtagaggtgcatttggagaagttcaattggtaaggcataaatccaccaggaag gtatatgctatgaagcttctcagcaaatttgaaatgataaagagatctgattctgctttt ttctgggaagaaagggacatcatggcttttgccaacagtccttgggttgttcagcttttt tatgcattccaagatgatcgttatctctacatggtgatggaatacatgcctggtggagat cttgtaaacttaatgagcaactatgatgtgcctgaaaaatgggcacgattctatactgca gaagtagttcttgcattggatgcaatccattccatgggttttattcacagagatgtgaag cctgataacatgctgctggataaatctggacatttgaagttagcagattttggtacttgt atgaagatgaataaggaaggcatggtacgatgtgatacagcggttggaacacctgattat atttcccctgaagtattaaaatcccaaggtggtgatggttattatggaagagaatgtgac tggtggtcggttggggtatttttatacgaaatgcttgtaggtgatacacctttttatgca gattctttggttggaacttacagtaaaattatgaaccataaaaattcacttacctttcct gatgataatgacatatcaaaagaagcaaaaaaccttatttgtgccttccttactgacagg gaagtgaggttagggcgaaatggtgtagaagaaatcaaacgacatctcttcttcaaaaat gaccagtgggcttgggaaacgctccgagacactgtagcaccagttgtacccgatttaagt agtgacattgatactagtaattttgatgacttggaagaagataaaggagaggaagaaaca ttccctattcctaaagctttcgttggcaatcaactaccttttgtaggatttacatattat agcaatcgtagatacttatcttcagcaaatcctaatgataacagaactagctccaatgca gataaaagcttgcaggaaagtttgcaaaaaacaatctataagctggaagaacagctgcat aatgaaatgcagttaaaagatgaaatggagcagaagtgcagaacctcaaacataaaacta gacaagataatgaaagaattggatgaagagggaaatcaaagaagaaatctagaatctaca gtgtctcagattgagaaggagaaaatgttgctacagcatagaattaatgagtaccaaaga aaagctgaacaggaaaatgagaagagaagaaatgtagaaaatgaagtttctacattaaag gatcagttggaagacttaaagaaagtcagtcagaattcacagcttgctaatgagaagctg tcccagttacaaaagcagctagaagaagccaatgacttacttaggacagaatcggacaca gctgtaagattgaggaagagtcacacagagatgagcaagtcaattagtcagttagagtcc ctgaacagagagttgcaagagagaaatcgaattttagagaattctaagtcacaaacagac aaagattattaccagctgcaagctatattagaagctgaacgaagagacagaggtcatgat tctgagatgattggagaccttcaagctcgaattacatctttacaagaggaggtgaagcat ctcaaacataatctcgaaaaagtggaaggagaaagaaaagaggctcaagacatgcttaat cactcagaaaaggaaaagaataatttagagatagatttaaactacaaacttaaatcatta caacaacggttagaacaagaggtaaatgaacacaaagtaaccaaagctcgtttaactgac aaacatcaatctattgaagaggcaaagtctgtggcaatgtgtgagatggaaaaaaagctg aaagaagaaagagaagctcgagagaaggctgaaaatcgggttgttcagattgagaaacag tgttccatgctagacgttgatctgaagcaatctcagcagaaactagaacatttgactgga aataaagaaaggatggaggatgaagttaagaatctaaccctgcaactggagcaggaatca aataagcggctgttgttacaaaatgaattgaagactcaagcatttgaggcagacaattta aaaggtttagaaaagcagatgaaacaggaaataaatactttattggaagcaaagagatta ttagaatttgagttagctcagcttacgaaacagtatagaggaaatgaaggacagatgcgg gagctacaagatcagcttgaagctgagcaatatttctcgacactttataaaacccaggta aaggaacttaaagaagaaattgaagaaaaaaacagagaaaatttaaagaaaatacaggaa ctacaaaatgaaaaagaaactcttgctactcagttggatctagcagaaacaaaagctgag tctgagcagttggcgcgaggccttctggaagaacagtattttgaattgacgcaagaaagc aagaaagctgcttcaagaaatagacaagagattacagataaagatcacactgttagtcgg cttgaagaagcaaacagcatgctaaccaaagatattgaaatattaagaagagagaatgaa gagctaacagagaaaatgaagaaggcagaggaagaatataaactggagaaggaggaggag atcagtaatcttaaggctgcctttgaaaagaatatcaacactgaacgaacccttaaaaca caggctgttaacaaattggcagaaataatgaatcgaaaagattttaaaattgatagaaag aaagctaatacacaagatttgagaaagaaagaaaaggaaaatcgaaagctgcaactggaa ctcaaccaagaaagagagaaattcaaccagatggtagtgaaacatcagaaggaactgaat gacatgcaagcgcaattggtagaagaatgtgcacataggaatgagcttcagatgcagttg gccagcaaagagagtgatattgagcaattgcgtgctaaacttttggacctctcggattct acaagtgttgctagttttcctagtgctgatgaaactgatggtaacctcccagagtcaaga attgaaggttggctttcagtaccaaatagaggaaatatcaaacgatatggctggaagaaa cagtatgttgtggtaagcagcaaaaaaattttgttctataatgacgaacaagataaggag caatccaatccatctatggtattggacatagataaactgtttcacgttagacctgtaacc caaggagatgtgtatagagctgaaactgaagaaattcctaaaatattccagatactatat gcaaatgaaggtgaatgtagaaaagatgtagagatggaaccagtacaacaagctgaaaaa actaatttccaaaatcacaaaggccatgagtttattcctacactctaccactttcctgcc aattgtgatgcctgtgccaaacctctctggcatgtttttaagccaccccctgccctagag tgtcgaagatgccatgttaagtgccacagagatcacttagataagaaagaggacttaatt tgtccatgtaaagtaagttatgatgtaacatcagcaagagatatgctgctgttagcatgt tctcaggatgaacaaaaaaaatgggtaactcatttagtaaagaaaatccctaagaatcca ccatctggttttgttcgtgcttcccctcgaacgctttctacaagatccactgcaaatcag tctttccggaaagtggtcaaaaatacatctggaaaaactagttaa |
Protein Sequence |
>6093 : length: 1354 MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS |