Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

841

Name

CASP8

Synonymous

ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5;caspase 8, apoptosis-related cysteine peptidase;CASP8;caspase 8, apoptosis-related cysteine peptidase

Definition

FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cystein

Position

2q33-q34

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr2:202098166-202152434chr2:202102685-202102685rs3769827Single_Nucleotides|eQTL|PPIL3, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|DNase-seq|Cmk, Chromatin_Structure|DNase-seq|Hl60, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|RFX3
chr2:202098166-202152434chr2:202119767-202119767rs13402616Single_Nucleotides|eQTL|PPIL3, Motifs|PWM|Hbp1, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Hrce
chr2:202098166-202152434chr2:202124502-202124502rs6735656Single_Nucleotides|eQTL|MGAT4B, Chromatin_Structure|DNase-seq|Th1, Chromatin_Structure|DNase-seq|Jurkat
chr2:202098166-202152434chr2:202124997-202124997rs6754084Single_Nucleotides|eQTL|PPIL3, Single_Nucleotides|eQTL|MGAT4B, Chromatin_Structure|DNase-seq|Caco2, Protein_Binding|ChIP-seq|ELF1, Protein_Binding|ChIP-seq|ETS1
chr2:202098166-202152434chr2:202126615-202126615rs1861270Single_Nucleotides|eQTL|MGAT4B, Motifs|Footprinting|MEIS1B:HOXA9, Motifs|PWM|MEIS1B:HOXA9, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Th2, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Jurkat
chr2:202098166-202152434chr2:202126708-202126708rs7568770Single_Nucleotides|eQTL|PPIL3, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Monocd14
chr2:202098166-202152434chr2:202143928-202143928rs10931936Single_Nucleotides|eQTL|MGAT4B, Motifs|PWM|PU.1, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Hmveclbl

Transcription Factors   [Top]

Regulation From TransFac database

proCaspase-8b(h) --> Caspase-8b-p41(h) + protein remnants (processing)
proCaspase-8b(h) --> Caspase-8b-p18(h) + protein remnants (processing)
c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding)
c-FLIP-L(h) + proCaspase-8b(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8b(h):Fas(h) (binding)
CASP8(h) --> proCaspase-8b(h) (expression).
CASP8(h) --> proCaspase-8c(h) (expression).
FADD(h) + proCaspase-8d(h) <==> FADD(h):proCaspase-8d(h) (binding)
proCaspase-8a(h) + proCaspase-8d(h) <==> proCaspase-8a(h):proCaspase-8d(h) (binding)
CASP8(h) --> proCaspase-8d(h) (expression).
CASP8(h) --> proCaspase-8e(h) (expression).
CASP8(h) --> proCaspase-8f(h) (expression).
CASP8(h) --> proCaspase-8g(h) (expression).
c-FLIP-L(h) + proCaspase-8(h) <==> c-FLIP-L(h):proCaspase-8(h) (binding)
c-FLIP-S(h) + proCaspase-8(h) <==> c-FLIP-S(h):proCaspase-8(h) (binding)
Apaf-1(h) + proCaspase-8(h) <==> Apaf-1(h):proCaspase-8(h) (binding)
BAR(h) + proCaspase-8(h) <==> BAR(h):proCaspase-8(h) (binding)
proCaspase-8(h) --Caspase-6(h)--> Caspase-8(h) (processing)
c-FLIP-L-p43(h) + FADD(h) + Fas(h) + FasL(h) + proCaspase-8(h) <==> FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding)
Hip-1(h) + proCaspase-8(h) <==> Hip-1(h):proCaspase-8(h) (binding)
Hippi(h) + proCaspase-8(h) <==> Hippi(h):proCaspase-8(h) (binding)
p38alpha(h) + proCaspase-8(h) <==> p38alpha(h):proCaspase-8(h) (binding)
p38alpha(h){p} + proCaspase-8(h) <==> p38alpha(h){p}:proCaspase-8(h) (binding)
proCaspase-8(h) + RIP3(h) <==> proCaspase-8(h):RIP3(h) (binding)
proCaspase-8(h) --> Caspase-8-p18(h) + Caspase-8-p12(h) + protein remnants (processing)
proCaspase-8(h) --Caspase-10(h)--> Caspase-8-p43(h) + Caspase-8-p12(h) + protein remnants (processing)
2 proCaspase-8(h) <==> (proCaspase-8(h))2 (binding)
proCaspase-8(h) --Caspase-3(v.s.)--> protein remnants (processing)
Apo2L(h) + proCaspase-8(h) <==> Apo2L(h):proCaspase-8(h) (binding)
FasL(h) + proCaspase-8(h) <==> FasL(h):proCaspase-8(h) (binding)
FAF1(h) + proCaspase-8(h) <==> FAF1(h):proCaspase-8(h) (binding)
proCaspase-8(h) + Fas(h) <==> Fas(h):proCaspase-8(h) (binding)
FADD(h) + proCaspase-8(h) <==> FADD(h):proCaspase-8(h) (binding)
proCaspase-8(h) + FADD(m.s.) <==> proCaspase-8(h):FADD(m.s.) (binding)
proCaspase-8(h) + Apo2L(h) + FADD(h) + DR5(h) <==> proCaspase-8(h):Apo2L(h):FADD(h):DR5(h) (binding)
proCaspase-8(h) + DEDD(m.s.) <==> proCaspase-8(h):DEDD(m.s.) (binding)
proCaspase-8(h) --> TRADD(h) (binding)
proCaspase-8(h) --> FADD(h) (binding)
proCaspase-8(h) --> TRAF2(h) (binding)
proCaspase-8(h) --> FAF1(m.s.) (activation)
proCaspase-8(h) --> Caspase-8-p43(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p41(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p18(h) + protein remnants (processing)
proCaspase-8(h) + ATP --> proCaspase-8(h){pY380} + ADP (phosphorylation)
proCaspase-8(h) + ATP --> proCaspase-8(h){pY} + ADP (phosphorylation)
c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-8(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-8(h) (binding)
c-FLIP-L-p43(h) + FADD(h) + proCaspase-8(h) + Fas(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h):proCaspase-8(h) (binding)
Apo2L(h) + DR5(h) + FADD(h) + proCaspase-8(h) + c-FLIP-L(h) <==> Apo2L(h):DR5(h):FADD(h):proCaspase-8(h):c-FLIP-L(h) (binding)
Fas(h) + FasL(h) + c-FLIP-S(m.s.) + FADD(h) + proCaspase-8(h) + c-FLIP-L-p43(h) <==> Fas(h):FasL(h):c-FLIP-S(m.s.):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding)
proCaspase-8(h) + c-FLIP-L(m.s.) <==> proCaspase-8(h):c-FLIP-L(m.s.) (binding)
FasL(h) + c-FLIP-S(m.s.) + proCaspase-8(h) <==> FasL(h):proCaspase-8(h):c-FLIP-S(m.s.) (binding)
FasL(h) + proCaspase-8(h) + c-FLIP-L-p43(h) + c-FLIP-S(m.s.) + RIP(h) <==> FasL(h):proCaspase-8(h):c-FLIP-L-p43(h):c-FLIP-S(m.s.):RIP(h) (binding)
proCaspase-8(h) --> Caspase-8-p16(h) + protein remnants (cleavage)
proCaspase-8(h) --Caspase-3(h)--> Caspase-8-p41(h) + protein remnants (cleavage)
proCaspase-8(h) --Caspase-6(h)--> Caspase-8-p41(h) + protein remnants (cleavage)
proCaspase-8(h) --Caspase-3(h)--> Caspase-8-p43(h) + protein remnants (cleavage)
proCaspase-8(h) --Caspase-6(h)--> Caspase-8-p43(h) + protein remnants (cleavage)
Apo2L(m.s.) + proCaspase-8(h) <==> Apo2L(m.s.):proCaspase-8(h) (binding)
proCaspase-8(h) --> Caspase-8-p26(h) + protein remnants (cleavage)
proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h) (binding)
proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h):c-FLIP-S(h) (binding)
Fas(h) + FADD(h) + proCaspase-8(h) + c-FLIP-p22(m.s.) <==> Fas(h):FADD(h):proCaspase-8(h):c-FLIP-p22(m.s.) (binding)
Fas(h) + proCaspase-8(h) + Caspase-2-p33(h) <==> Fas(h):proCaspase-8(h):Caspase-2-p33(h) (binding)
Fas(h) + proCaspase-2(h) + proCaspase-8(h) <==> Fas(h):proCaspase-2(h):proCaspase-8(h) (binding)
proCaspase-8(h) --Caspase-3(m.s.)--> Caspase-8-p43(h) + protein remnants (cleavage)
proCaspase-8(h) --Caspase-3(m.s.)--> Caspase-8-p41(h) + protein remnants (cleavage)
proCaspase-8(h) + GMEB-1(h) <==> proCaspase-8(h):GMEB-1(h) (binding)
Fas(h) + FADD(h) + proCaspase-8(h) <==> Fas(h):FADD(h):proCaspase-8(h) (binding)
proCaspase-8(h) --> Caspase-8-p53(h) + protein remnants (cleavage)
proCaspase-8(h) --> protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p44(h) + protein remnants (processing)
Fas(h) + proCaspase-8(h) + FADD(h) <==> Fas(h):proCaspase-8(h):FADD(h) (binding)
proCaspase-8(h) + FADD(h) <==> proCaspase-8(h):FADD(h) (binding)
RIP(m.s.) + proCaspase-8(h) <==> RIP(m.s.):proCaspase-8(h) (binding)
proCaspase-8(h) --> Caspase-8-p40(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p17(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p20(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p42(h) + protein remnants (processing)
proCaspase-8(h) + FADD(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding)
FLASH(m.s.) + TRAF2(h) + proCaspase-8(h) <==> FLASH(m.s.):TRAF2(h):proCaspase-8(h) (binding)
proCaspase-8(h) --> Caspase-8-p28(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8-p45(h) + protein remnants (processing)
proCaspase-8(h) --> Caspase-8(h) + protein remnants (cleavage)
proCaspase-8(h) --> Caspase-8-p23(h) + protein remnants (cleavage)
CASP8(h) --> proCaspase-8(h) (expression).
TNFR1(h) --> proCaspase-8(h) (binding)
Apo2L(m.s.) --> proCaspase-8(h) (activation)
Daxx(h) --> proCaspase-8(h) (increase of processing)
Fas(h) --> proCaspase-8(h) (increase of processing)
Apo2L(h) --> proCaspase-8(h) (increase of processing)
c-FLIP-L(m.s.) --proCaspase-8(h)--> c-FLIP-L-p33(m.s.) + c-FLIP-L-p22(m.s.) (cleavage)
FADD(h) + proCaspase-8a(h) <==> FADD(h):proCaspase-8a(h) (binding)
proCaspase-8a(h) + proCaspase-8d(h) <==> proCaspase-8a(h):proCaspase-8d(h) (binding)
FADD(v.s.) + proCaspase-8a(h) <==> FADD(v.s.):proCaspase-8a(h) (binding)
proCaspase-8a(h) --> Caspase-8a-p43(h) + Caspase-8a-p12(h) (processing)
proCaspase-8a(h) --FasL(h)--> Caspase-8a-p20(h) + Caspase-8a-p12(h) + protein remnants (processing)
proCaspase-8a(h) --Apo2L(h)--> Caspase-8a-p20(h) + Caspase-8a-p12(h) + protein remnants (processing)
proCaspase-8a(h) + GMEB1-xbb2(h) <==> proCaspase-8a(h):GMEB1-xbb2(h) (binding)
proCaspase-8a(h) --> Caspase-8a-p43(h) + protein remnants (processing)
proCaspase-8a(h) --> Caspase-8a-p18(h) + protein remnants (processing)
c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding)
c-FLIP-L(h) + proCaspase-8a(h) + Fas(h) <==> c-FLIP-L(h):proCaspase-8a(h):Fas(h) (binding)
CASP8(h) --> proCaspase-8a(h) (expression).
CASP8(h) --> proCaspase-8h(h) (expression).
CASP8(h) --> proCaspase-8-isoform-3(h) (expression).
CASP8(h) --> proCaspase-8-isoform-4(h) (expression).
CASP8(h) --> proCaspase-8-isoform-6(h) (expression).
CASP8(h) --> proCaspase-8-isoform-9(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

188Phosphoserine (By similarity).Swiss-Prot 53.0
334Phosphotyrosine.Swiss-Prot 53.0
334Phosphotyrosine15592455Phospho.ELM 6.0
347Phosphoserine (MAPK14)14970175Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

 Promoter: 201804911 - 201806911GoldenGate_Methylation_Cancer_Panel_I

chr2

 Promoter: 201804911 - 201806911GoldenGate_Methylation_Cancer_Panel_I

chr2

 Promoter: 201804911 - 201806911GoldenGate_Methylation_Cancer_Panel_I

chr2

 Promoter: 201804911 - 201806911GoldenGate_Methylation_Cancer_Panel_I

chr2

 Promoter: 201804911 - 201806911GSE27584

chr2

 Promoter: 201829499 - 201831499GSE27584

chr2

 Promoter: 201804911 - 201806911GSE27584

chr2

 Promoter: 201804911 - 201806911GSE27584

chr2

 Promoter: 201804911 - 201806911GSE27584

chr2

 Promoter: 201829499 - 201831499Agilent_014791

chr2

 Promoter: 201804911 - 201806911PMID:14688019

chr2

 Promoter: 201829499 - 201831499PMID:14688019

chr2

 Promoter: 201804911 - 201806911PMID:14688019

chr2

 Promoter: 201804911 - 201806911PMID:14688019

chr2

 Promoter: 201831968 - 201833968PMID:14688019

chr2

 Promoter: 201804911 - 201806911PMID:14688019

chr2

 Promoter: 201804911 - 201806911PMID:15029256

chr2

 Promoter: 201829499 - 201831499PMID:15029256

chr2

 Promoter: 201804911 - 201806911PMID:15029256

chr2

 Promoter: 201804911 - 201806911PMID:15029256

chr2

 Promoter: 201831968 - 201833968PMID:15029256

chr2

 Promoter: 201804911 - 201806911PMID:15029256

chr2

 Promoter: 201804911 - 201806911PMID:16688669

chr2

 Promoter: 201829499 - 201831499PMID:16688669

chr2

 Promoter: 201804911 - 201806911PMID:16688669

chr2

 Promoter: 201804911 - 201806911PMID:16688669

chr2

 Promoter: 201831968 - 201833968PMID:16688669

chr2

 Promoter: 201804911 - 201806911PMID:16688669

chr2

 Promoter: 201804911 - 201806911PMID:16616114

chr2

 Promoter: 201829499 - 201831499PMID:16616114

chr2

 Promoter: 201804911 - 201806911PMID:16616114

chr2

 Promoter: 201804911 - 201806911PMID:16616114

chr2

 Promoter: 201831968 - 201833968PMID:16616114

chr2

 Promoter: 201804911 - 201806911PMID:16616114

chr2

 Promoter: 201804911 - 201806911PMID:16051033

chr2

 Promoter: 201829499 - 201831499PMID:16051033

chr2

 Promoter: 201804911 - 201806911PMID:16051033

chr2

 Promoter: 201804911 - 201806911PMID:16051033

chr2

 Promoter: 201831968 - 201833968PMID:16051033

chr2

 Promoter: 201804911 - 201806911PMID:16051033

chr2

 Promoter: 201804911 - 201806911PMID:16983315

chr2

 Promoter: 201829499 - 201831499PMID:16983315

chr2

 Promoter: 201804911 - 201806911PMID:16983315

chr2

 Promoter: 201804911 - 201806911PMID:16983315

chr2

 Promoter: 201831968 - 201833968PMID:16983315

chr2

 Promoter: 201804911 - 201806911PMID:16983315

chr2

 Promoter: 201804911 - 201806911PMID:15365725

chr2

 Promoter: 201829499 - 201831499PMID:15365725

chr2

 Promoter: 201804911 - 201806911PMID:15365725

chr2

 Promoter: 201804911 - 201806911PMID:15365725

chr2

 Promoter: 201831968 - 201833968PMID:15365725

chr2

 Promoter: 201804911 - 201806911PMID:15365725

chr2

 Promoter: 201804911 - 201806911PMID:17272309

chr2

 Promoter: 201829499 - 201831499PMID:17272309

chr2

 Promoter: 201804911 - 201806911PMID:17272309

chr2

 Promoter: 201804911 - 201806911PMID:17272309

chr2

 Promoter: 201831968 - 201833968PMID:17272309

chr2

 Promoter: 201804911 - 201806911PMID:17272309

chr2

 Promoter: 201804911 - 201806911PMID:11709729

chr2

 Promoter: 201829499 - 201831499PMID:11709729

chr2

 Promoter: 201804911 - 201806911PMID:11709729

chr2

 Promoter: 201804911 - 201806911PMID:11709729

chr2

 Promoter: 201831968 - 201833968PMID:11709729

chr2

 Promoter: 201804911 - 201806911PMID:11709729

chr2

 Promoter: 201804911 - 201806911PMID:15788647

chr2

 Promoter: 201829499 - 201831499PMID:15788647

chr2

 Promoter: 201804911 - 201806911PMID:15788647

chr2

 Promoter: 201804911 - 201806911PMID:15788647

chr2

 Promoter: 201831968 - 201833968PMID:15788647

chr2

 Promoter: 201804911 - 201806911PMID:15788647

chr2

 Promoter: 201804911 - 201806911PMID:12826052

chr2

 Promoter: 201829499 - 201831499PMID:12826052

chr2

 Promoter: 201804911 - 201806911PMID:12826052

chr2

 Promoter: 201804911 - 201806911PMID:12826052

chr2

 Promoter: 201831968 - 201833968PMID:12826052

chr2

 Promoter: 201804911 - 201806911PMID:12826052

chr2

 Promoter: 201804911 - 201806911PMID:17064406

chr2

 Promoter: 201829499 - 201831499PMID:17064406

chr2

 Promoter: 201804911 - 201806911PMID:17064406

chr2

 Promoter: 201804911 - 201806911PMID:17064406

chr2

 Promoter: 201831968 - 201833968PMID:17064406

chr2

 Promoter: 201804911 - 201806911PMID:17064406

chr2

 Promoter: 201804911 - 201806911PMID:12433278

chr2

 Promoter: 201829499 - 201831499PMID:12433278

chr2

 Promoter: 201804911 - 201806911PMID:12433278

chr2

 Promoter: 201804911 - 201806911PMID:12433278

chr2

 Promoter: 201831968 - 201833968PMID:12433278

chr2

 Promoter: 201804911 - 201806911PMID:12433278

chr2

 Promoter: 201804911 - 201806911PMID:12632081

chr2

 Promoter: 201829499 - 201831499PMID:12632081

chr2

 Promoter: 201804911 - 201806911PMID:12632081

chr2

 Promoter: 201804911 - 201806911PMID:12632081

chr2

 Promoter: 201831968 - 201833968PMID:12632081

chr2

 Promoter: 201804911 - 201806911PMID:12632081

chr2

 Promoter: 201804911 - 201806911PMID:14555992

chr2

 Promoter: 201829499 - 201831499PMID:14555992

chr2

 Promoter: 201804911 - 201806911PMID:14555992

chr2

 Promoter: 201804911 - 201806911PMID:14555992

chr2

 Promoter: 201831968 - 201833968PMID:14555992

chr2

 Promoter: 201804911 - 201806911PMID:14555992

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