CleftGeneDB-Download

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Download data sets:

File #	File name	Download
1	All genes related to cleft lip/palate from 11 eukaryotes with basic information.	Download
2	Experimentally identified genes associated with cleft lip/palate in humans and mice with references.	Download
3	Cleft related orthologous groups identified from the Orthologous Matrix (OMA) ortholog database.	Download
4	Gene expression in 53 human tissues from GTEx and ENCODE.	Download
5	Identified variants/mutations related to cleft phenotype.	Download
6	Other genetic variants and mutations in cleft genes.	Download
7	Disease or phenotype and drug-associated information for cleft genes.	Download
8	Gene Ontology, biological pathways and functional annotations for cleft genes.	Download
9	Protein structural annotations for cleft genes.	Download
10	Protein-protein interactions and gene-miRNA interactions for cleft genes.	Download

References and supplemental data:

Previous publications for systematic review and analyses of cleft lip and palate genes in humans and mice.

Suzuki A, Abdallah N, Gajera M, Jia P, Jun G, Zhao Z, Iwata J (2018) Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mechanisms of Development 150 (2018): 21-27. [Full Text] [Supplemental tables ]
Suzuki, A., Jun, G., Abdallah, N., Gajera, M., & Iwata, J (2018) Gene datasets associated with mouse cleft palate. Data in Brief 18, 655-673. [Full Text] [Supplemental tables ]
Gajera, M, Desai N, Suzuki A, Li A, Zhang M, Jun G, Jia P, Zhao Z, Iwata J (2019) MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip. BMC Medical Genomics 12(1):70. [Full Text] [Supplemental tables ]
Suzuki A, Li A, Gajera M, Abdallah N, Pelikan RC, Zhao Z, Iwata J (2019) MicroRNA-374a, -4680, and -133b suppress cell proliferation through the regulation of genes associated with human cleft palate in cultured human palate cells. BMC Medical Genomics 12:93. [Full Text] [Supplemental tables ]
Suzuki A, Yoshioka H, Summakia D, Desai N, Jun G, Jia P, Loose D, Ogata K, Gajera M, Zhao Z, Iwata J (2019) MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse. BMC Genomics 20(1):852. [Full Text] [Supplemental tables ]
Li A, Qin G, Suzuki A, Gejera M, Iwata J, Jia P, Zhao Z (2019) Network-based identification of critical regulators as putative drivers of human cleft lip. BMC Medical Genomics 12(Suppl 1): 16. [Full Text]
Yan F, Dai Y, Iwata J, Zhao Z, Jia P (2020) An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate. BMC Medical Genomics. 13(suppl 5):39. [Full Text]
Li A, Jia P, Mallik S, Fei R, Yoshioka H, Suzuki A, Iwata J, Zhao Z* (2019) Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA-TF-gene network approach in humans and mice. Briefing in Bioinformatics, bbz082. [Full Text]