| Tag | Content |
|---|---|
| Uniprot ID | A2ARV4; P70215; Q3TL35; Q9JLB3; |
| Entrez ID | 14725 |
| Genbank protein ID | BAE38957.1; AAF61488.1; CAA69877.1; |
| Genbank nucleotide ID | NM_001081088.1 |
| Ensembl protein ID | ENSMUSP00000079752 |
| Ensembl nucleotide ID | ENSMUSG00000027070 |
| Gene name | Low-density lipoprotein receptor-related protein 2 |
| Gene symbol | Lrp2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23968836; 8710893; 15623804; |
| Functional description | Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (PubMed:10766831). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (PubMed:22841573). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (PubMed:24825475). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (PubMed:10052453). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (PubMed:18174160). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (PubMed:15623804). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (PubMed:22340494). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (PubMed:24639464). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (PubMed:20460439). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (PubMed:20637285). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (PubMed:22354480). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (PubMed:26439398). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensin 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (PubMed:26822476). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082). |
| Sequence | MERGAAAAAW MLLLAIAACL APVSGQECGS GNFRCDNGYC IPASWRCDGT RDCLDDTDEI 60 GCPPRSCGSG FFLCPAEGTC IPSSWVCDQD KDCSDGADEQ QNCPGTTCSS QQLTCSNGQC 120 VPIEYRCDHV SDCPDGSDER NCYYPTCDQL TCANGACYNT SQKCDHKVDC RDSSDEANCT 180 TLCSQKEFQC GSGECILRAY VCDHDNDCED NSDEHNCNYD TCGGHQFTCS NGQCINQNWV 240 CDGDDDCQDS GDEDGCESNQ RHHTCYPREW ACPGSGRCIS MDKVCDGVPD CPEGEDENNA 300 TSGRYCGTGL CSILNCEYQC HQTPYGGECF CPPGHIINSN DSRTCIDFDD CQIWGICDQK 360 CESRQGRHQC LCEEGYILER GQHCKSNDSF SAASIIFSNG RDLLVGDLHG RNFRILAESK 420 NRGIVMGVDF HYQKHRVFWT DPMQAKVFST DINGLNTQEI LNVSIDAPEN LAVDWINNKL 480 YLVETRVNRI DVVNLEGNQR VTLITENLGH PRGIALDPTV GYLFFSDWGS LSGQPKVERA 540 FMDGSNRKDL VTTKLGWPAG ITLDLVSKRV YWVDSRYDYI ETVTYDGIQR KTVARGGSLV 600 PHPFGISLFE EHVFFTDWTK MAVMKANKFT DTNPQVYHQS SLTPFGVTVY HALRQPNATN 660 PCGNNNGGCA QICVLSHRTD NGGLGYRCKC EFGFELDADE HHCVAVKNFL LFSSQTAVRG 720 IPFTLSTQED VMVPVTGSPS FFVGIDFDAQ HSTIFYSDLS KNIIYQQKID GTGKEVITAN 780 RLQNVECLSF DWISRNLYWT DGGSKSVTVM KLADKSRRQI ISNLNNPRSI VVHPAAGYMF 840 LSDWFRPAKI MRAWSDGSHL MPIVNTSLGW PNGLAIDWST SRLYWVDAFF DKIEHSNLDG 900 LDRKRLGHVD QMTHPFGLTV FKDNVFLTDW RLGAIIRVRK SDGGDMTVVR RGISSIMHVK 960 AYDADLQTGT NYCSQTTHPN GDCSHFCFPV PNFQRVCGCP YGMKLQRDQM TCEGDPAREP 1020 PTQQCGSSSF PCNNGKCVPS IFRCDGVDDC HDNSDEHQCG ALNNTCSSSA FTCVHGGQCI 1080 PGQWRCDKQN DCLDGSDEQN CPTRSPSSTC PPTSFTCDNH MCIPKEWVCD TDNDCSDGSD 1140 EKNCQASGTC HPTQFRCPDH RCISPLYVCD GDKDCVDGSD EAGCVLNCTS SQFKCADGSS 1200 CINSRYRCDG VYDCKDNSDE AGCPTRPPGM CHPDEFQCQG DGTCIPNTWE CDGHPDCIQG 1260 SDEHNGCVPK TCSPSHFLCD NGNCIYNSWV CDGDNDCRDM SDEKDCPTQP FHCPSSQWQC 1320 PGYSICVNLS ALCDGVFDCP NGTDESPLCN QDSCLHFNGG CTHRCIQGPF GATCVCPIGY 1380 QLANDTKTCE DVNECDIPGF CSQHCVNMRG SFRCACDPEY TLESDGRTCK VTASENLLLV 1440 VASRDKIIMD NITAHTHNIY SLVQDVSFVV ALDFDSVTGR VFWSDLLEGK TWSAFQNGTD 1500 KRVVHDSGLS LTEMIAVDWI GRNIYWTDYT LETIEVSKID GSHRTVLISK NVTKPRGLAL 1560 DPRMGDNVMF WSDWGHHPRI ERASMDGTMR TVIVQEKIYW PCGLSIDYPN RLIYFMDAYL 1620 DYIEFCDYDG QNRRQVIASD LVLHHPHALT LFEDSVFWTD RGTHQVMQAN KWHGRNQSVV 1680 MYSVPQPLGI IAIHPSRQPS SPNPCASATC SHLCLLSAQE PRHYSCACPS GWNLSDDSVN 1740 CVRGDQPFLI SVRENVIFGI SLDPEVKSND AMVPISGIQH GYDVEFDDSE QFIYWVENPG 1800 EIHRVKTDGS NRTAFAPLSL LGSSLGLALD WVSRNIYYTT PASRSIEVLT LRGDTRYGKT 1860 LITNDGTPLG VGFPVGIAVD PARGKLYWSD HGTDSGVPAK IASANMDGTS LKILFTGNME 1920 HLEVVTLDIQ EQKLYWAVTS RGVIERGNVD GTERMILVHH LAHPWGLVVH GSFLYYSDEQ 1980 YEVIERVDKS SGSNKVVFRD NIPYLRGLRV YHHRNAADSS NGCSNNPNAC QQICLPVPGG 2040 MFSCACASGF KLSPDGRSCS PYNSFIVVSM LPAVRGFSLE LSDHSEAMVP VAGQGRNVLH 2100 ADVDVANGFI YWCDFSSSVR SSNGIRRIKP NGSNFTNIVT YGIGANGIRG VAVDWVAGNL 2160 YFTNAFVYET LIEVIRINTT YRRVLLKVSV DMPRHIVVDP KHRYLFWADY GQKPKIERSF 2220 LDCTNRTVLV SEGIVTPRGL AVDHDTGYIY WVDDSLDIIA RIHRDGGESQ VVRYGSRYPT 2280 PYGITVFGES IIWVDRNLRK VFQASKQPGN TDPPTVIRDS INLLRDVTIF DEHVQPLSPA 2340 ELNNNPCLQS NGGCSHFCFA LPELPTPKCG CAFGTLEDDG KNCATSREDF LIYSLNNSLR 2400 SLHFDPQDHN LPFQAISVEG MAIALDYDRR NNRIFFTQKL NPIRGQISYV NLYSGASSPT 2460 ILLSNIGVTD GIAFDWINRR IYYSDFSNQT INSMAEDGSN RAVIARVSKP RAIVLDPCRG 2520 YMYWTDWGTN AKIERATLGG NFRVPIVNTS LVWPNGLTLD LETDLLYWAD ASLQKIERST 2580 LTGSNREVVI STAFHSFGLT VYGQYIYWTD FYTKKIYRAN KYDGSDLIAM TTRLPTQPSG 2640 ISTVVKTQQQ QCSNPCDQFN GGCSHICAPG PNGAECQCPH EGSWYLANDN KYCVVDTGAR 2700 CNQFQFTCLN GRCISQDWKC DNDNDCGDGS DELPTVCAFH TCRSTAFTCA NGRCVPYHYR 2760 CDFYNDCGDN SDEAGCLFRS CNSTTEFTCS NGRCIPLSYV CNGINNCHDN DTSDEKNCPP 2820 ITCQPDFAKC QTTNICVPRA FLCDGDNDCG DGSDENPIYC ASHTCRSNEF QCVSPHRCIP 2880 SYWFCDGEAD CVDSSDEPDT CGHSLNSCSA NQFHCDNGRC ISSSWVCDGD NDCGDMSDED 2940 QRHHCELQNC SSTEFTCINS RPPNRRCIPQ HWVCDGDADC ADALDELQNC TMRACSTGEF 3000 SCANGRCIRQ SFRCDRRNDC GDYSDERGCS YPPCRDDQFT CQNGQCITKL YVCDEDNDCG 3060 DGSDEQEHLC HTPEPTCPPH QFRCDNGHCI EMGTVCNHVD DCSDNSDEKG CGINECQDSS 3120 ISHCDHNCTD TITSFYCSCL PGYKLMSDKR TCVDIDECKE TPQLCSQKCE NVIGSYICKC 3180 APGYIREPDG KSCRQNSNIE PYLVFSNRYY IRNLTIDGTS YSLILQGLGN VVALDFDRVE 3240 ERLYWIDAEK QIIERMFLNK TNQETIISHR LRRAESLAVD WVSRKLYWLD AILDCLFVSD 3300 LEGRQRKMLA QHCVDANNTF CFENPRGIVL HPQRGYVYWA DWGDHAYIAR IGMDGTNKTV 3360 IISTKIEWPN AITIDYTNDL LYWADAHLGY IEFSDLEGHH RHTVYDGTLP HPFALTIFED 3420 TVFWTDWNTR TVEKGNKYDG SGRVVLVNTT HKPFDIHVLH PYRQPIMSNP CATNNGGCSH 3480 LCLIKAGGRG FTCECPDDFQ TVQLRDRTLC MPMCSSTQFL CGNNEKCIPI WWKCDGQKDC 3540 SDGSDESDLC PHRFCRLGQF QCRDGNCTSP QALCNARQDC ADGSDEDRVL CEHHRCEANE 3600 WQCANKRCIP EYWQCDSVDD CLDNSDEDPS HCASRTCRPG QFKCNNGRCI PQSWKCDVDN 3660 DCGDYSDEPI HECMTAAYNC DNHTEFSCKT NYRCIPQWAV CNGFDDCRDN SDEQGCESVP 3720 CHPSGDFRCG NHHCIPLRWK CDGIDDCGDN SDEESCVPRE CTESEFRCAD QQCIPSRWVC 3780 DQENDCGDNS DERDCEMKTC HPEHFQCTSG HCVPKALACD GRADCLDASD ESACPTRFPN 3840 GTYCPAAMFE CKNHVCIQSF WICDGENDCV DGSDEEIHLC FNVPCESPQR FRCDNSRCIY 3900 GHQLCNGVDD CGDGSDEKEE HCRKPTHKPC TDTEYKCSNG NCVSQHYVCD NVDDCGDLSD 3960 ETGCNLGENR TCAEKICEQN CTQLSNGGFI CSCRPGFKPS TLDKNSCQDI NECEEFGICP 4020 QSCRNSKGSY ECFCVDGFKS MSTHYGERCA ADGSPPLLLL PENVRIRKYN ISSEKFSEYL 4080 EEEEHIQAID YDWDPEGIGL SVVYYTVLSQ GSQFGAIKRA YLPDFESGSN NPVREVDLGL 4140 KYLMQPDGLA VDWVGRHIYW SDAKSQRIEV ATLDGRYRKW LITTQLDQPA AIAVNPKLGL 4200 MFWTDQGKQP KIESAWMNGE HRSVLASANL GWPNGLSIDY LNGDRIYWSD SKEDVIESIK 4260 YDGTDRRLII NDAMKPFSLD IFEDQLYWVA KEKGEVWRQN KFGKGNKEKL LVVNPWLTQV 4320 RIFHQLRYNQ SVSNPCKQVC SHLCLLRPGG YSCACPQGSD FVTGSTVECD AASELPITMP 4380 SPCRCMHGGS CYFDENDLPK CKCSSGYSGE YCEIGLSRGI PPGTTMALLL TFAMVIIVGA 4440 LVLVGFFHYR KTGSLLPSLP KLPSLSSLAK PSENGNGVTF RSGADVNMDI GVSPFGPETI 4500 IDRSMAMNEQ FVMEVGKQPV IFENPMYAAK DSTSKVGLAV QGPSVSSQVT VPENVENQNY 4560 GRSIDPSEIV PEPKPASPGA DETQGTKWNI FKRKPKQTTN FENPIYAEMD TEQKEAVAVA 4620 PPPSPSLPAK ASKRSSTPGY TATEDTFKDT ANLVKEDSDV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005509 | calcium ion binding | ISS |
| GO:0005509 | calcium ion binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008144 | drug binding | ISS |
| GO:0008144 | drug binding | ISO |
| GO:0017124 | SH3 domain binding | IEA |
| GO:0030165 | PDZ domain binding | ISO |
| GO:0030492 | hemoglobin binding | ISO |
| GO:0031994 | insulin-like growth factor I binding | ISO |
| GO:0035258 | steroid hormone receptor binding | ISO |
| GO:0042562 | hormone binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0050750 | low-density lipoprotein particle receptor binding | ISO |
| GO:0051087 | chaperone binding | ISO |
| GO:0140318 | protein transporter activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001843 | neural tube closure | IMP |
| GO:0003139 | secondary heart field specification | IMP |
| GO:0003148 | outflow tract septum morphogenesis | IMP |
| GO:0003223 | ventricular compact myocardium morphogenesis | IMP |
| GO:0003281 | ventricular septum development | IMP |
| GO:0006766 | vitamin metabolic process | IMP |
| GO:0006897 | endocytosis | ISO |
| GO:0006898 | receptor-mediated endocytosis | ISO |
| GO:0006898 | receptor-mediated endocytosis | IMP |
| GO:0006898 | receptor-mediated endocytosis | IDA |
| GO:0007507 | heart development | IMP |
| GO:0007605 | sensory perception of sound | IMP |
| GO:0008283 | cell population proliferation | IMP |
| GO:0008584 | male gonad development | IMP |
| GO:0010165 | response to X-ray | ISO |
| GO:0015031 | protein transport | IDA |
| GO:0016197 | endosomal transport | ISO |
| GO:0020028 | endocytic hemoglobin import | ISO |
| GO:0030001 | metal ion transport | ISS |
| GO:0030001 | metal ion transport | ISO |
| GO:0030514 | negative regulation of BMP signaling pathway | IMP |
| GO:0030900 | forebrain development | IMP |
| GO:0035904 | aorta development | IMP |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0044321 | response to leptin | IDA |
| GO:0045056 | transcytosis | ISO |
| GO:0045807 | positive regulation of endocytosis | ISO |
| GO:0046879 | hormone secretion | ISO |
| GO:0050769 | positive regulation of neurogenesis | IMP |
| GO:0051897 | positive regulation of protein kinase B signaling | ISO |
| GO:0060068 | vagina development | IMP |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0060982 | coronary artery morphogenesis | IMP |
| GO:0061156 | pulmonary artery morphogenesis | IMP |
| GO:0061642 | chemoattraction of axon | ISO |
| GO:0070447 | positive regulation of oligodendrocyte progenitor proliferation | IMP |
| GO:0071363 | cellular response to growth factor stimulus | ISO |
| GO:0097242 | amyloid-beta clearance | ISO |
| GO:0140058 | neuron projection arborization | IMP |
| GO:0140077 | positive regulation of lipoprotein transport | ISO |
| GO:1904447 | folate import across plasma membrane | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005768 | endosome | ISO |
| GO:0005768 | endosome | IDA |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005903 | brush border | ISO |
| GO:0005903 | brush border | IDA |
| GO:0005905 | clathrin-coated pit | IDA |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0009986 | cell surface | ISO |
| GO:0016020 | membrane | ISO |
| GO:0016020 | membrane | IDA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0016324 | apical plasma membrane | ISS |
| GO:0016324 | apical plasma membrane | ISO |
| GO:0016324 | apical plasma membrane | IDA |
| GO:0030139 | endocytic vesicle | IDA |
| GO:0030424 | axon | IDA |
| GO:0030425 | dendrite | IDA |
| GO:0031526 | brush border membrane | ISS |
| GO:0031526 | brush border membrane | ISO |
| GO:0031526 | brush border membrane | IDA |
| GO:0031904 | endosome lumen | IEA |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043235 | receptor complex | ISO |
| GO:0044295 | axonal growth cone | ISO |
| GO:0045121 | membrane raft | ISO |
| GO:0045177 | apical part of cell | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-196854 | Metabolism of vitamins and cofactors | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-2187338 | Visual phototransduction | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-418594 | G alpha (i) signalling events | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-6806667 | Metabolism of fat-soluble vitamins | IEA |
| R-MMU-8856825 | Cargo recognition for clathrin-mediated endocytosis | IEA |
| R-MMU-8856828 | Clathrin-mediated endocytosis | IEA |
| R-MMU-975634 | Retinoid metabolism and transport | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0168 | Coated pit |
| KW-1015 | Disulfide bond |
| KW-0245 | EGF-like domain |
| KW-0254 | Endocytosis |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-1009 | Hearing |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0729 | SH3-binding |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0813 | Transport |
| InterPro ID | InterPro Term |
|---|---|
| IPR011042 | 6-blade_b-propeller_TolB-like |
| IPR026823 | cEGF |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR036055 | LDL_receptor-like_sf |
| IPR023415 | LDLR_class-A_CS |
| IPR000033 | LDLR_classB_rpt |
| IPR002172 | LDrepeatLR_classA_rpt |