| Tag | Content |
|---|---|
| Uniprot ID | O14520; Q08E94; Q5T5L9; Q8NHM3; |
| Entrez ID | 364 |
| Genbank protein ID | BAA21745.1; BAC05693.1; AAI19674.1; BAF98770.1; BAH13332.1; AAI19673.1; |
| Genbank nucleotide ID | XM_005251453.3; NM_001318157.1; NM_001170.2; NM_001318158.1; XM_011517866.2; |
| Ensembl protein ID | ENSP00000412868; ENSP00000297988; |
| Ensembl nucleotide ID | ENSG00000165269 |
| Gene name | Aquaporin-7 |
| Gene symbol | AQP7 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26449438 |
| Functional description | Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). |
| Sequence | MVQASGHRRS TRGSKMVSWS VIAKIQEILQ RKMVREFLAE FMSTYVMMVF GLGSVAHMVL 60 NKKYGSYLGV NLGFGFGVTM GVHVAGRISG AHMNAAVTFA NCALGRVPWR KFPVYVLGQF 120 LGSFLAAATI YSLFYTAILH FSGGQLMVTG PVATAGIFAT YLPDHMTLWR GFLNEAWLTG 180 MLQLCLFAIT DQENNPALPG TEALVIGILV VIIGVSLGMN TGYAINPSRD LPPRIFTFIA 240 GWGKQVFSNG ENWWWVPVVA PLLGAYLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 300 LPKMGSHEPT ISPLTPVSVS PANRSSVHPA PPLHESMALE HF 342 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.