Gene: NRP1

Basic information

Tag Content
Uniprot ID O14786; B0LPG9; O60461; Q5T7F1; Q5T7F2; Q5T7F3; Q86T59; Q96I90; Q96IH5;
Entrez ID 8829
Genbank protein ID AAH07533.1; AAF44344.1; ABY87548.1; EAW85944.1; AAC12921.1; AAP35641.1; EAW85942.1; AAH07737.1; CAD91133.1; AAC51759.1;
Genbank nucleotide ID NM_001024629.2; NM_003873.5; NM_001330068.1; NM_001024628.2;
Ensembl protein ID ENSP00000363955; ENSP00000363954; ENSP00000364001; ENSP00000265371;
Ensembl nucleotide ID ENSG00000099250
Gene name Neuropilin-1
Gene symbol NRP1
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
Sequence
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA 60
PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF 120
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTTPSGVIKS PGFPEKYPNS LECTYIVFVP 180
KMSEIILEFE SFDLEPDSNP PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS 240
GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 300
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYKI 360
DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI TRFVRIKPAT WETGISMRFE 420
VYGCKITDYP CSGMLGMVSG LISDSQITSS NQGDRNWMPE NIRLVTSRSG WALPPAPHSY 480
INEWLQIDLG EEKIVRGIII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF 540
EGNNNYDTPE LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 600
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF 660
CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH 720
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI 780
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD 840
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900
FELVDGVKLK KDKLNTQSTY SEA 923

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNRP1102175037A0A452DVS7Capra hircusPredictionMore>>
1:1 orthologNRP18829O14786Homo sapiensPredictionMore>>
1:1 orthologNrp118186P97333CPOMus musculusPublicationMore>>
1:1 orthologNRP1450397A0A2I3TPR4Pan troglodytesPredictionMore>>
1:1 orthologNrp1246331Q9QWJ9Rattus norvegicusPredictionMore>>
1:1 ortholognrp1a353246Q1RLY9Danio rerioPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005021 vascular endothelial growth factor-activated receptor activityISS
GO:0005021 vascular endothelial growth factor-activated receptor activityNAS
GO:0005096 GTPase activator activityIMP
GO:0005515 protein bindingIPI
GO:0008201 heparin bindingIEA
GO:0015026 coreceptor activityTAS
GO:0017154 semaphorin receptor activityNAS
GO:0019838 growth factor bindingTAS
GO:0019838 growth factor bindingIPI
GO:0019901 protein kinase bindingIEA
GO:0019955 cytokine bindingNAS
GO:0038085 vascular endothelial growth factor bindingIPI
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001525 angiogenesisIMP
GO:0001525 angiogenesisISS
GO:0001569 branching involved in blood vessel morphogenesisISS
GO:0001764 neuron migrationISS
GO:0001938 positive regulation of endothelial cell proliferationTAS
GO:0002040 sprouting angiogenesisISS
GO:0002042 cell migration involved in sprouting angiogenesisISS
GO:0003148 outflow tract septum morphogenesisISS
GO:0006930 substrate-dependent cell migration, cell extensionIMP
GO:0007165 signal transductionTAS
GO:0007229 integrin-mediated signaling pathwayIMP
GO:0007267 cell-cell signalingTAS
GO:0007411 axon guidanceNAS
GO:0007413 axonal fasciculationIEA
GO:0009611 response to woundingIEA
GO:0009887 animal organ morphogenesisTAS
GO:0010595 positive regulation of endothelial cell migrationTAS
GO:0010595 positive regulation of endothelial cell migrationIMP
GO:0014911 positive regulation of smooth muscle cell migrationTAS
GO:0021612 facial nerve structural organizationIEA
GO:0021637 trigeminal nerve structural organizationIEA
GO:0021649 vestibulocochlear nerve structural organizationIEA
GO:0021675 nerve developmentISS
GO:0021785 branchiomotor neuron axon guidanceIEA
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA
GO:0031290 retinal ganglion cell axon guidanceISS
GO:0031532 actin cytoskeleton reorganizationIMP
GO:0032489 regulation of Cdc42 protein signal transductionIMP
GO:0034446 substrate adhesion-dependent cell spreadingIMP
GO:0035729 cellular response to hepatocyte growth factor stimulusIMP
GO:0035767 endothelial cell chemotaxisIMP
GO:0035924 cellular response to vascular endothelial growth factor stimulusISS
GO:0036486 ventral trunk neural crest cell migrationIEA
GO:0038189 neuropilin signaling pathwayIMP
GO:0038190 VEGF-activated neuropilin signaling pathwayISS
GO:0038190 VEGF-activated neuropilin signaling pathwayIMP
GO:0042327 positive regulation of phosphorylationIMP
GO:0043524 negative regulation of neuron apoptotic processIEA
GO:0043542 endothelial cell migrationIMP
GO:0043547 positive regulation of GTPase activityIEA
GO:0048008 platelet-derived growth factor receptor signaling pathwayIMP
GO:0048010 vascular endothelial growth factor receptor signaling pathwayIMP
GO:0048010 vascular endothelial growth factor receptor signaling pathwayTAS
GO:0048012 hepatocyte growth factor receptor signaling pathwayIMP
GO:0048842 positive regulation of axon extension involved in axon guidanceISS
GO:0048843 negative regulation of axon extension involved in axon guidanceIEA
GO:0048844 artery morphogenesisISS
GO:0048846 axon extension involved in axon guidanceISS
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylationIMP
GO:0050918 positive chemotaxisISS
GO:0051491 positive regulation of filopodium assemblyIMP
GO:0051496 positive regulation of stress fiber assemblyIMP
GO:0051894 positive regulation of focal adhesion assemblyIDA
GO:0060301 positive regulation of cytokine activityTAS
GO:0060385 axonogenesis involved in innervationISS
GO:0060627 regulation of vesicle-mediated transportTAS
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branchingIEA
GO:0060978 angiogenesis involved in coronary vascular morphogenesisISS
GO:0060982 coronary artery morphogenesisIEA
GO:0061299 retina vasculature morphogenesis in camera-type eyeISS
GO:0061441 renal artery morphogenesisIEA
GO:0061549 sympathetic ganglion developmentISS
GO:0061551 trigeminal ganglion developmentIEA
GO:0070374 positive regulation of ERK1 and ERK2 cascadeISS
GO:0071526 semaphorin-plexin signaling pathwayNAS
GO:0071679 commissural neuron axon guidanceISS
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesisIEA
GO:0090259 regulation of retinal ganglion cell axon guidanceISS
GO:0097102 endothelial tip cell fate specificationISS
GO:0097374 sensory neuron axon guidanceIEA
GO:0097475 motor neuron migrationISS
GO:0097490 sympathetic neuron projection extensionISS
GO:0097491 sympathetic neuron projection guidanceISS
GO:0099173 postsynapse organizationIEA
GO:0150018 basal dendrite developmentISS
GO:0150020 basal dendrite arborizationISS
GO:1900026 positive regulation of substrate adhesion-dependent cell spreadingIMP
GO:1901166 neural crest cell migration involved in autonomic nervous system developmentISS
GO:1901998 toxin transportIEA
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidanceISS
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidanceIEA
GO:1902336 positive regulation of retinal ganglion cell axon guidanceISS
GO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidanceIEA
GO:1902946 protein localization to early endosomeISS
GO:1903375 facioacoustic ganglion developmentIEA
GO:1904835 dorsal root ganglion morphogenesisIEA
GO:1905040 otic placode developmentIEA
GO:2000251 positive regulation of actin cytoskeleton reorganizationIMP
GO:2001237 negative regulation of extrinsic apoptotic signaling pathwayIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0002116 semaphorin receptor complexNAS
GO:0005615 extracellular spaceHDA
GO:0005769 early endosomeISS
GO:0005829 cytosolIDA
GO:0005883 neurofilamentIEA
GO:0005886 plasma membraneIDA
GO:0005886 plasma membraneTAS
GO:0005925 focal adhesionHDA
GO:0005925 focal adhesionIDA
GO:0009986 cell surfaceIEA
GO:0030424 axonISS
GO:0030426 growth coneIEA
GO:0031410 cytoplasmic vesicleTAS
GO:0031966 mitochondrial membraneIEA
GO:0043005 neuron projectionISS
GO:0043025 neuronal cell bodyIEA
GO:0043235 receptor complexTAS
GO:0097443 sorting endosomeISS
GO:0098978 glutamatergic synapseIEA
GO:0099055 integral component of postsynaptic membraneIEA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-1266738 Developmental BiologyTAS
R-HSA-1266738 Developmental BiologyIEA
R-HSA-162582 Signal TransductionTAS
R-HSA-194138 Signaling by VEGFTAS
R-HSA-194306 Neurophilin interactions with VEGF and VEGFRTAS
R-HSA-373755 Semaphorin interactionsTAS
R-HSA-373755 Semaphorin interactionsIEA
R-HSA-373760 L1CAM interactionsIEA
R-HSA-373760 L1CAM interactionsTAS
R-HSA-376176 Signaling by ROBO receptorsIEA
R-HSA-399954 Sema3A PAK dependent Axon repulsionTAS
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionIEA
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionTAS
R-HSA-399956 CRMPs in Sema3A signalingTAS
R-HSA-399956 CRMPs in Sema3A signalingIEA
R-HSA-422475 Axon guidanceTAS
R-HSA-422475 Axon guidanceIEA
R-HSA-445144 Signal transduction by L1TAS
R-HSA-447041 CHL1 interactionsIEA
R-HSA-9006934 Signaling by Receptor Tyrosine KinasesTAS

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0025 Alternative splicing
KW-0037 Angiogenesis
KW-0106 Calcium
KW-1003 Cell membrane
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0903 Direct protein sequencing
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0357 Heparan sulfate
KW-0358 Heparin-binding
KW-0472 Membrane
KW-0479 Metal-binding
KW-0496 Mitochondrion
KW-0524 Neurogenesis
KW-0597 Phosphoprotein
KW-0621 Polymorphism
KW-0654 Proteoglycan
KW-0675 Receptor
KW-1185 Reference proteome
KW-0677 Repeat
KW-0964 Secreted
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS01180 CUB
PS01285 FA58C_1
PS01286 FA58C_2
PS50022 FA58C_3
PS00740 MAM_1
PS50060 MAM_2

Pfam

Pfam ID Pfam Term
PF00431 CUB
PF11980 DUF3481
PF00754 F5_F8_type_C
PF00629 MAM

Protein-protein interaction

Protein-miRNA interaction