| Tag | Content |
|---|---|
| Uniprot ID | O15409; A0AUV6; A4D0U8; A6NNW4; B4DLD9; Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; Q8NFQ2; Q8NFQ3; Q8NFQ4; Q8TD74; |
| Entrez ID | 93986 |
| Genbank protein ID | BAD18444.1; AAN03403.1; EAW83484.1; AAN60016.1; AAN03395.1; AAN03405.1; AAL10762.1; AAB91439.1; AAM60767.1; AAM60762.1; AAI43867.1; AAN03406.1; EAW83486.1; AAM60763.1; AAN03402.1; AAN03396.1; AAN03399.1; AAN03390.1; EAL24367.1; AAN03401.1; AAS07399.1; AAN03404.1; AAM60765.1; AAN03391.1; AAI26105.1; AAM13672.1; AAN03398.1; AAS07502.1; AAN03394.1; AAM60764.1; AAN03392.1; AAN03408.1; EAL24369.1; AAM60766.1; AAN03393.1; BAG59501.1; AAN03397.1; AAN03400.1; AAN03389.1; AAN03407.1; |
| Genbank nucleotide ID | XM_017012801.1; NM_148900.3; NM_014491.3; NM_001172767.2; NM_148899.3; NM_148898.3; NM_001172766.2; |
| Ensembl protein ID | ENSP00000377132; ENSP00000265436; ENSP00000405470; ENSP00000385069; ENSP00000386200; ENSP00000416825; ENSP00000489457; ENSP00000367482; ENSP00000353367; ENSP00000377129; |
| Ensembl nucleotide ID | ENSG00000128573 |
| Gene name | Forkhead box protein P2 |
| Gene symbol | FOXP2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26868259 |
| Functional description | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| Sequence | MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 60 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 120 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 180 QQQQQQQQQQ QHPGKQAKEQ QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG 240 LISIPPGQAA LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 300 SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW PGCESICEDF 360 GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE RLQAMMTHLH MRPSEPKPSP 420 KPLNLVSSVT MSKNMLETSP QSLPQTPTTP TAPVTPITQG PSVITPASVP NVGAIRRRHS 480 DKYNIPMSSE IAPNYEFYKN ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY 540 FRRNAATWKN AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT 600 SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD HIDSNGNSSP 660 GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE DDREIEEEPL SEDLE 715 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.