CleftGeneDB-Search

Gene: FGF10

Basic information

Tag	Content
Uniprot ID	O15520; C7FDY0; Q6FHR3; Q6FHT6; Q96P59;
Entrez ID	2255
Genbank protein ID	BAA22331.1; AAI05022.1; CAG46489.1; AAI05024.1; AAL05875.1; EAW56075.1; ACU00617.1; AAH69561.1; AAB61991.1; AAS99733.1; CAG46466.1;
Genbank nucleotide ID	XM_005248264.3; NM_004465.1;
Ensembl protein ID	ENSP00000264664
Ensembl nucleotide ID	ENSG00000070193
Gene name	Fibroblast growth factor 10
Gene symbol	FGF10
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	28232668
Functional description	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Sequence	MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP 60 SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV 120 VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL 180 NGKGAPRRGQ KTRRKNTSAH FLPMVVHS 208

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1NUN

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	FGF10	612454	J9NVD5			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	FGF10	102174339	A0A142I1Y0			Capra hircus	Prediction	More>>
1:1 ortholog	FGF10	100052655	F7CND4			Equus caballus	Prediction	More>>
1:1 ortholog	FGF10	2255	O15520			Homo sapiens	Publication	More>>
1:1 ortholog	Fgf10	14165	O35565	CPO	E11.5, E11.75, E12.5, E13.5, E14.5, E15.5, E16.5	Mus musculus	Publication	More>>
1:1 ortholog	FGF10	471553	A0A2I3T2G6			Pan troglodytes	Prediction	More>>
1:1 ortholog	FGF10		F1SMG2			Sus scrofa	Prediction	More>>
1:1 ortholog	FGF10	100342802	G1SVA6			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Fgf10	25443	P70492			Rattus norvegicus	Prediction	More>>
1:1 ortholog	fgf10b		A0A0R4ITI2			Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
FGF10	rs10462065C>A	GWAS	28232668

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs199671312	p.Trp2Ser	missense variant	-	NC_000005.10:g.44388678C>G	-
rs1347979233	p.Trp2Cys	missense variant	-	NC_000005.10:g.44388677C>A	gnomAD
rs1441196548	p.Ile5Thr	missense variant	-	NC_000005.10:g.44388669A>G	TOPMed
COSM3855396	p.Ile5Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388669A>C	NCI-TCGA Cosmic
rs201659493	p.Leu6Pro	missense variant	-	NC_000005.10:g.44388666A>G	gnomAD
rs747476439	p.Leu6Val	missense variant	-	NC_000005.10:g.44388667G>C	ExAC,gnomAD
NCI-TCGA novel	p.Leu6Met	missense variant	-	NC_000005.10:g.44388667G>T	NCI-TCGA
rs200886626	p.Thr7Ile	missense variant	-	NC_000005.10:g.44388663G>A	ExAC,gnomAD
rs1402567148	p.Ala10Val	missense variant	-	NC_000005.10:g.44388654G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Ser11Ter	stop gained	-	NC_000005.10:g.44388651G>C	NCI-TCGA
rs148032639	p.Pro14Leu	missense variant	-	NC_000005.10:g.44388642G>A	ESP,ExAC,TOPMed,gnomAD
rs754826334	p.Pro14Ser	missense variant	-	NC_000005.10:g.44388643G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu16Gln	missense variant	-	NC_000005.10:g.44388636A>T	NCI-TCGA
rs374755098	p.Pro17Thr	missense variant	-	NC_000005.10:g.44388634G>T	ESP,ExAC,gnomAD
rs374755098	p.Pro17Ser	missense variant	-	NC_000005.10:g.44388634G>A	ESP,ExAC,gnomAD
rs766989043	p.Gly18Ser	missense variant	-	NC_000005.10:g.44388631C>T	ExAC,TOPMed,gnomAD
rs766989043	p.Gly18Cys	missense variant	-	NC_000005.10:g.44388631C>A	ExAC,TOPMed,gnomAD
rs201408864	p.Gly18Val	missense variant	-	NC_000005.10:g.44388630C>A	gnomAD
rs761359401	p.Cys19Gly	missense variant	-	NC_000005.10:g.44388628A>C	ExAC,TOPMed,gnomAD
rs1272336613	p.Cys21Tyr	missense variant	-	NC_000005.10:g.44388621C>T	gnomAD
rs200247528	p.Cys22Arg	missense variant	-	NC_000005.10:g.44388619A>G	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu26Trp	missense variant	-	NC_000005.10:g.44388606A>C	NCI-TCGA
NCI-TCGA novel	p.Leu27Met	missense variant	-	NC_000005.10:g.44388604G>T	NCI-TCGA
rs199806461	p.Phe28Leu	missense variant	-	NC_000005.10:g.44388599G>T	-
NCI-TCGA novel	p.Leu29Trp	missense variant	-	NC_000005.10:g.44388597A>C	NCI-TCGA
rs1284421241	p.Val30Met	missense variant	-	NC_000005.10:g.44388595C>T	gnomAD
rs1223515236	p.Val30Ala	missense variant	-	NC_000005.10:g.44388594A>G	gnomAD
rs762625065	p.Ser31Thr	missense variant	-	NC_000005.10:g.44388592A>T	ExAC,gnomAD
COSM1068457	p.Ser31Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388591G>A	NCI-TCGA Cosmic
rs145373611	p.Val33Ile	missense variant	-	NC_000005.10:g.44388586C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1007631855	p.Val35Ala	missense variant	-	NC_000005.10:g.44388579A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Thr36Ser	missense variant	-	NC_000005.10:g.44388576G>C	NCI-TCGA
NCI-TCGA novel	p.Cys37Tyr	missense variant	-	NC_000005.10:g.44388573C>T	NCI-TCGA
rs201790067	p.Ala39Val	missense variant	-	NC_000005.10:g.44388567G>A	ExAC,gnomAD
rs146669375	p.Leu40Phe	missense variant	-	NC_000005.10:g.44388565G>A	ESP,ExAC,TOPMed,gnomAD
rs146669375	p.Leu40Val	missense variant	-	NC_000005.10:g.44388565G>C	ESP,ExAC,TOPMed,gnomAD
COSM1496129	p.Leu40Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388565G>T	NCI-TCGA Cosmic
rs772109862	p.Gly41Asp	missense variant	-	NC_000005.10:g.44388561C>T	ExAC,TOPMed,gnomAD
rs1429390732	p.Gln42Leu	missense variant	-	NC_000005.10:g.44388558T>A	gnomAD
rs1409855200	p.Asp43Gly	missense variant	-	NC_000005.10:g.44388555T>C	TOPMed,gnomAD
rs778802173	p.Asp43Asn	missense variant	-	NC_000005.10:g.44388556C>T	ExAC,TOPMed,gnomAD
rs778802173	p.Asp43Tyr	missense variant	-	NC_000005.10:g.44388556C>A	ExAC,TOPMed,gnomAD
rs779848984	p.Met44Thr	missense variant	-	NC_000005.10:g.44388552A>G	ExAC,gnomAD
rs201168313	p.Met44Val	missense variant	-	NC_000005.10:g.44388553T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs201168313	p.Met44Leu	missense variant	-	NC_000005.10:g.44388553T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1232465320	p.Val45Glu	missense variant	-	NC_000005.10:g.44388549A>T	TOPMed,gnomAD
rs750371676	p.Ser46Leu	missense variant	-	NC_000005.10:g.44388546G>A	ExAC,gnomAD
rs527933059	p.Pro47Ser	missense variant	-	NC_000005.10:g.44388544G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs751081612	p.Ala49Val	missense variant	-	NC_000005.10:g.44388537G>A	ExAC,gnomAD
rs751081612	p.Ala49Gly	missense variant	-	NC_000005.10:g.44388537G>C	ExAC,gnomAD
rs751081612	p.Ala49Asp	missense variant	-	NC_000005.10:g.44388537G>T	ExAC,gnomAD
NCI-TCGA novel	p.Ala49Thr	missense variant	-	NC_000005.10:g.44388538C>T	NCI-TCGA
rs144567587	p.Thr50Ser	missense variant	-	NC_000005.10:g.44388535T>A	ESP,ExAC,TOPMed,gnomAD
rs775259892	p.Ser52Tyr	missense variant	-	NC_000005.10:g.44388528G>T	ExAC,TOPMed,gnomAD
rs762714965	p.Ser52Thr	missense variant	-	NC_000005.10:g.44388529A>T	ExAC,gnomAD
rs775259892	p.Ser52Cys	missense variant	-	NC_000005.10:g.44388528G>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser53Pro	missense variant	-	NC_000005.10:g.44388526A>G	NCI-TCGA
NCI-TCGA novel	p.Ser54Phe	missense variant	-	NC_000005.10:g.44388522G>A	NCI-TCGA
COSM3616762	p.Ser55Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388519G>A	NCI-TCGA Cosmic
rs773650137	p.Phe57Leu	missense variant	-	NC_000005.10:g.44388512G>C	ExAC,gnomAD
rs761116992	p.Phe57Val	missense variant	-	NC_000005.10:g.44388514A>C	ExAC,gnomAD
rs1462552463	p.Ser58Tyr	missense variant	-	NC_000005.10:g.44388510G>T	TOPMed
rs201038841	p.Ser59Phe	missense variant	-	NC_000005.10:g.44388507G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser59Tyr	missense variant	-	NC_000005.10:g.44388507G>T	NCI-TCGA
rs199850745	p.Pro60Arg	missense variant	-	NC_000005.10:g.44388504G>C	TOPMed
rs199850745	p.Pro60His	missense variant	-	NC_000005.10:g.44388504G>T	TOPMed
NCI-TCGA novel	p.Pro60Thr	missense variant	-	NC_000005.10:g.44388505G>T	NCI-TCGA
rs774523215	p.Ser61Phe	missense variant	-	NC_000005.10:g.44388501G>A	ExAC,TOPMed,gnomAD
rs774523215	p.Ser61Cys	missense variant	-	NC_000005.10:g.44388501G>C	ExAC,TOPMed,gnomAD
rs886060654	p.Ser62Arg	missense variant	-	NC_000005.10:g.44388497G>T	gnomAD
rs898009871	p.Ser62Gly	missense variant	-	NC_000005.10:g.44388499T>C	TOPMed,gnomAD
rs886060654	p.Ser62Arg	missense variant	-	NC_000005.10:g.44388497G>C	gnomAD
NCI-TCGA novel	p.Ser62Asn	missense variant	-	NC_000005.10:g.44388498C>T	NCI-TCGA
rs201676495	p.Gly64Val	missense variant	-	NC_000005.10:g.44388492C>A	ExAC,TOPMed,gnomAD
rs1446723373	p.Gly64Arg	missense variant	-	NC_000005.10:g.44388493C>T	gnomAD
rs1203071781	p.Arg65Ser	missense variant	-	NC_000005.10:g.44388488C>A	gnomAD
rs562084259	p.His66Tyr	missense variant	-	NC_000005.10:g.44388487G>A	1000Genomes
COSM1437687	p.Arg68Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388480C>T	NCI-TCGA Cosmic
rs780222015	p.Ser69Asn	missense variant	-	NC_000005.10:g.44388477C>T	ExAC,gnomAD
rs541818263	p.Asn71Ser	missense variant	-	NC_000005.10:g.44388471T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs745684641	p.His72Tyr	missense variant	-	NC_000005.10:g.44388469G>A	ExAC,gnomAD
rs199689272	p.Asp76Glu	missense variant	-	NC_000005.10:g.44388455A>T	1000Genomes,ExAC
COSM3855394	p.Trp79Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388448A>C	NCI-TCGA Cosmic
rs104893888	p.Arg80Ser	missense variant	-	NC_000005.10:g.44388443T>G	TOPMed
COSM1437686	p.Arg80Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388444C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu82Ile	missense variant	-	NC_000005.10:g.44388439G>T	NCI-TCGA
NCI-TCGA novel	p.Ser84PhePheSerTerUnk	frameshift	-	NC_000005.10:g.44388431_44388432AG>-	NCI-TCGA
COSM449707	p.Thr86Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388426G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys87Asn	missense variant	-	NC_000005.10:g.44388422C>A	NCI-TCGA
NCI-TCGA novel	p.Tyr88ThrPheSerTerUnkUnk	frameshift	-	NC_000005.10:g.44388421A>-	NCI-TCGA
rs757950282	p.Leu90Val	missense variant	-	NC_000005.10:g.44388415G>C	ExAC,gnomAD
COSM3429485	p.Leu90Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388415G>T	NCI-TCGA Cosmic
rs752464185	p.Lys91Arg	missense variant	-	NC_000005.10:g.44388411T>C	ExAC,gnomAD
NCI-TCGA novel	p.Ile92Met	missense variant	-	NC_000005.10:g.44388407A>C	NCI-TCGA
rs1258016531	p.Glu93Val	missense variant	-	NC_000005.10:g.44388405T>A	TOPMed
COSM6171277	p.Glu93Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388404C>G	NCI-TCGA Cosmic
rs1363470725	p.Asn95Lys	missense variant	-	NC_000005.10:g.44388398G>C	gnomAD
rs1274894561	p.Lys97Glu	missense variant	-	NC_000005.10:g.44388394T>C	TOPMed,gnomAD
rs764969764	p.Ser99Asn	missense variant	-	NC_000005.10:g.44388387C>T	ExAC,gnomAD
rs759054084	p.Ser99Arg	missense variant	-	NC_000005.10:g.44388386G>T	ExAC,gnomAD
COSM4413111	p.Gly100Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44388385C>T	NCI-TCGA Cosmic
rs1428980854	p.Asn105Ser	missense variant	-	NC_000005.10:g.44388369T>C	TOPMed
NCI-TCGA novel	p.Asn105Lys	missense variant	-	NC_000005.10:g.44388368G>C	NCI-TCGA
rs104893885	p.Cys106Phe	missense variant	Lacrimo-auriculo-dento-digital syndrome (LADDS)	NC_000005.10:g.44388366C>A	UniProt,dbSNP
VAR_029888	p.Cys106Phe	missense variant	Lacrimo-auriculo-dento-digital syndrome (LADDS)	NC_000005.10:g.44388366C>A	UniProt
rs104893885	p.Cys106Phe	missense variant	-	NC_000005.10:g.44388366C>A	-
rs200701392	p.Pro107Arg	missense variant	-	NC_000005.10:g.44388363G>C	TOPMed,gnomAD
rs200701392	p.Pro107Leu	missense variant	-	NC_000005.10:g.44388363G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Pro107Thr	missense variant	-	NC_000005.10:g.44388364G>T	NCI-TCGA
rs1183240121	p.Tyr108His	missense variant	-	NC_000005.10:g.44388361A>G	gnomAD
NCI-TCGA novel	p.Ser109Ile	missense variant	-	NC_000005.10:g.44310530C>A	NCI-TCGA
NCI-TCGA novel	p.Ile110SerPheSerTerUnk	frameshift	-	NC_000005.10:g.44310527_44310528insATAGC	NCI-TCGA
NCI-TCGA novel	p.Leu111GlyPheSerTerUnk	frameshift	-	NC_000005.10:g.44310525_44310526insACACC	NCI-TCGA
NCI-TCGA novel	p.Glu112Trp	insertion	-	NC_000005.10:g.44310519_44310520insCCA	NCI-TCGA
rs1207676419	p.Ile113Met	missense variant	-	NC_000005.10:g.44310517T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Val116Leu	missense variant	-	NC_000005.10:g.44310510C>A	NCI-TCGA
rs201385181	p.Ile118Met	missense variant	-	NC_000005.10:g.44310502G>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly119Ter	stop gained	-	NC_000005.10:g.44310501C>A	NCI-TCGA
rs769710686	p.Val120Ile	missense variant	-	NC_000005.10:g.44310498C>T	ExAC,gnomAD
rs1225998924	p.Ala122Thr	missense variant	-	NC_000005.10:g.44310492C>T	gnomAD
rs776683911	p.Val123Ile	missense variant	-	NC_000005.10:g.44310489C>T	ExAC,TOPMed,gnomAD
rs1467091511	p.Val123Ala	missense variant	-	NC_000005.10:g.44310488A>G	TOPMed
COSM1207048	p.Ser128Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44310473C>T	NCI-TCGA Cosmic
rs145888320	p.Tyr130Cys	missense variant	-	NC_000005.10:g.44310467T>C	ESP,ExAC,TOPMed,gnomAD
COSM3855392	p.Leu132Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44310462A>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Met134Ile	missense variant	-	NC_000005.10:g.44310454C>T	NCI-TCGA
NCI-TCGA novel	p.Met134Ile	missense variant	-	NC_000005.10:g.44310454C>A	NCI-TCGA
rs746766662	p.Asn135Ser	missense variant	-	NC_000005.10:g.44310452T>C	ExAC,gnomAD
rs1398855772	p.Lys136Asn	missense variant	-	NC_000005.10:g.44310448C>G	gnomAD
NCI-TCGA novel	p.Lys137Glu	missense variant	-	NC_000005.10:g.44310447T>C	NCI-TCGA
rs866583243	p.Gly138Arg	missense variant	-	NC_000005.10:g.44310444C>T	-
rs866583243	p.Gly138Arg	missense variant	-	NC_000005.10:g.44310444C>T	NCI-TCGA
rs1421578299	p.Ser143Leu	missense variant	-	NC_000005.10:g.44310428G>A	gnomAD
COSM5682558	p.Lys144Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000005.10:g.44305192T>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp149Asn	missense variant	-	NC_000005.10:g.44305177C>T	NCI-TCGA
COSM1068455	p.Lys151Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44305170T>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys151AsnAsnGlnGlyProHisGlyLysLysTer	stop gained	-	NC_000005.10:g.44305169_44305170insTATTTTTTCCCATGGGGCCCCTGGTTA	NCI-TCGA
NCI-TCGA novel	p.Lys151AsnGlnGlyProHisGlyLysLysTer	stop gained	-	NC_000005.10:g.44305169_44305170insTATTTTTTCCCATGGGGCCCCTGG	NCI-TCGA
NCI-TCGA novel	p.Leu152AsnPheSerTerUnk	frameshift	-	NC_000005.10:g.44305168_44305169insTT	NCI-TCGA
rs1409489572	p.Arg155Lys	missense variant	-	NC_000005.10:g.44305158C>T	TOPMed,gnomAD
rs104893886	p.Ile156Arg	missense variant	Lacrimo-auriculo-dento-digital syndrome (LADDS)	NC_000005.10:g.44305155A>C	UniProt,dbSNP
VAR_029889	p.Ile156Arg	missense variant	Lacrimo-auriculo-dento-digital syndrome (LADDS)	NC_000005.10:g.44305155A>C	UniProt
rs104893886	p.Ile156Arg	missense variant	-	NC_000005.10:g.44305155A>C	-
COSM351231	p.Glu157Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44305151C>A	NCI-TCGA Cosmic
COSM6104075	p.Asn159Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44305145A>T	NCI-TCGA Cosmic
COSM6171278	p.Tyr161Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000005.10:g.44305139G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asn162LeuPheSerTerUnkUnk	frameshift	-	NC_000005.10:g.44305138_44305139insTATTATGGATTTGTAG	NCI-TCGA
rs1206827871	p.Thr163Ile	missense variant	-	NC_000005.10:g.44305134G>A	gnomAD
rs1374899961	p.Phe167Leu	missense variant	-	NC_000005.10:g.44305123A>G	gnomAD
rs758742613	p.Gln170Lys	missense variant	-	NC_000005.10:g.44305114G>T	ExAC,gnomAD
rs1456457163	p.His171Tyr	missense variant	-	NC_000005.10:g.44305111G>A	TOPMed
rs1200591041	p.Arg174Thr	missense variant	-	NC_000005.10:g.44305101C>G	TOPMed
NCI-TCGA novel	p.Met176Arg	missense variant	-	NC_000005.10:g.44305095A>C	NCI-TCGA
rs1453394033	p.Tyr177Phe	missense variant	-	NC_000005.10:g.44305092T>A	gnomAD
NCI-TCGA novel	p.Val178Met	missense variant	-	NC_000005.10:g.44305090C>T	NCI-TCGA
rs1332768200	p.Asn181Asp	missense variant	-	NC_000005.10:g.44305081T>C	gnomAD
rs1332768200	p.Asn181His	missense variant	-	NC_000005.10:g.44305081T>G	gnomAD
NCI-TCGA novel	p.Gly182Val	missense variant	-	NC_000005.10:g.44305077C>A	NCI-TCGA
NCI-TCGA novel	p.Gly182Glu	missense variant	-	NC_000005.10:g.44305077C>T	NCI-TCGA
rs1442319696	p.Arg187Lys	missense variant	-	NC_000005.10:g.44305062C>T	TOPMed
rs183142365	p.Arg188Ile	missense variant	-	NC_000005.10:g.44305059C>A	1000Genomes
NCI-TCGA novel	p.Arg188Lys	missense variant	-	NC_000005.10:g.44305059C>T	NCI-TCGA
rs1013456350	p.Gln190Glu	missense variant	-	NC_000005.10:g.44305054G>C	TOPMed,gnomAD
rs1403015185	p.Gln190His	missense variant	-	NC_000005.10:g.44305052C>G	gnomAD
rs104893884	p.Arg193Ter	stop gained	-	NC_000005.10:g.44305045G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1158466327	p.Arg193Gln	missense variant	-	NC_000005.10:g.44305044C>T	NCI-TCGA Cosmic
rs104893884	p.Arg193Gly	missense variant	-	NC_000005.10:g.44305045G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs1158466327	p.Arg193Gln	missense variant	-	NC_000005.10:g.44305044C>T	TOPMed,gnomAD
rs1418284908	p.Arg194Lys	missense variant	-	NC_000005.10:g.44305041C>T	gnomAD
COSM738693	p.Lys195Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44305038T>A	NCI-TCGA Cosmic
rs1165118219	p.Lys195Arg	missense variant	-	NC_000005.10:g.44305038T>C	TOPMed
NCI-TCGA novel	p.Lys195Glu	missense variant	-	NC_000005.10:g.44305039T>C	NCI-TCGA
rs1163839847	p.Thr197Ile	missense variant	-	NC_000005.10:g.44305032G>A	gnomAD
rs1235308786	p.Ser198Cys	missense variant	-	NC_000005.10:g.44305029G>C	TOPMed,gnomAD
NCI-TCGA novel	p.Ser198Phe	missense variant	-	NC_000005.10:g.44305029G>A	NCI-TCGA
COSM3855391	p.Ala199Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000005.10:g.44305026G>A	NCI-TCGA Cosmic
rs150695565	p.Met204Val	missense variant	-	NC_000005.10:g.44305012T>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Met204Ile	missense variant	-	NC_000005.10:g.44305010C>A	NCI-TCGA
rs773535125	p.Val205Met	missense variant	-	NC_000005.10:g.44305009C>T	ExAC,TOPMed,gnomAD
rs202151850	p.Val206Leu	missense variant	-	NC_000005.10:g.44305006C>A	1000Genomes,gnomAD
rs202151850	p.Val206Ile	missense variant	-	NC_000005.10:g.44305006C>T	1000Genomes,gnomAD
NCI-TCGA novel	p.Val206Ala	missense variant	-	NC_000005.10:g.44305005A>G	NCI-TCGA
rs147715509	p.His207Arg	missense variant	-	NC_000005.10:g.44305002T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147715509	p.His207Pro	missense variant	-	NC_000005.10:g.44305002T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0000846	Agenesis	disease	BEFREE
C0001193	Apert syndrome	disease	BEFREE
C0002448	Ameloblastoma	disease	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0006287	Bronchopulmonary Dysplasia	disease	BEFREE
C0008924	Cleft upper lip	disease	CTD_human;LHGDN
C0008925	Cleft Palate	disease	BEFREE;CTD_human
C0010043	Corneal Ulcer	disease	HPO
C0010278	Craniosynostosis	disease	GENOMICS_ENGLAND
C0010668	Cystic Adenomatoid Malformation of Lung, Congenital	disease	BEFREE
C0010930	Dacryocystitis	phenotype	HPO
C0011334	Dental caries	disease	HPO
C0011351	Dental Enamel Hypoplasia	disease	HPO
C0018798	Congenital Heart Defects	group	BEFREE
C0020534	Orbital separation excessive	phenotype	HPO
C0020608	Hypodontia	disease	HPO
C0021828	Intestinal Atresia	disease	MGD
C0022906	Lacrimal Duct Obstruction	phenotype	HPO
C0024115	Lung diseases	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0027092	Myopia	disease	BEFREE
C0027404	Narcolepsy	disease	GWASDB
C0027719	Nephrosclerosis	disease	HPO
C0030297	Pancreatic Neoplasm	disease	LHGDN
C0030354	Papilloma	disease	BEFREE
C0033578	Prostatic Neoplasms	group	BEFREE;CTD_human
C0034063	Pulmonary Edema	disease	BEFREE
C0035334	Retinitis Pigmentosa	disease	BEFREE
C0040583	Tracheal Stenosis	disease	BEFREE
C0043352	Xerostomia	disease	HPO
C0151971	Primary ulcer of intestine	disease	BEFREE
C0152021	Congenital heart disease	group	BEFREE
C0152427	Polydactyly	disease	GENOMICS_ENGLAND
C0155119	Recurrent erosion of cornea	disease	HPO
C0155552	Hearing Loss, Mixed Conductive-Sensorineural	disease	HPO
C0158667	Aplasia of Lacrimal and Salivary Glands	disease	BEFREE;CLINVAR;CTD_human;ORPHANET
C0220668	Congenital contractural arachnodactyly	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0241074	Hyperextensible skin	phenotype	HPO
C0265269	Lacrimoauriculodentodigital syndrome	disease	BEFREE;CLINVAR;CTD_human;MGD;ORPHANET;UNIPROT
C0265857	Uhl anomaly	disease	BEFREE
C0266184	Congenital duodenal obstruction due to malrotation of intestine	disease	BEFREE
C0269102	Endometrioma	disease	BEFREE
C0282488	Interstitial Cystitis	disease	LHGDN
C0282612	Prostatic Intraepithelial Neoplasias	disease	BEFREE
C0339293	Corneal Perforation	phenotype	HPO
C0344505	Alacrima	disease	HPO
C0344509	Agenesis of punctum lacrimale	disease	HPO
C0345354	Radial polydactyly	disease	HPO
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	CTD_human
C0423110	Downward slant of palpebral fissure	phenotype	HPO
C0423113	Telecanthus	phenotype	HPO
C0432055	Simple syndactyly of fingers - first web	disease	HPO
C0476089	Endometrial Carcinoma	disease	BEFREE
C0542519	Congenital absence of kidney	disease	HPO
C0553723	Squamous cell carcinoma of skin	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	GWASCAT;GWASDB
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0685381	Congenital hypoplasia of radius	disease	HPO
C0848558	Hypospadias	group	BEFREE;RGD
C0948060	Iridocele	disease	HPO
C1145628	Autonomic nervous system disorders	group	BEFREE
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1266144	Pleuropulmonary blastoma	disease	BEFREE
C1281931	Obstruction of nasolacrimal duct	phenotype	HPO
C1394030	Coronal hypospadias	disease	HPO
C1400252	Hypoplasia of parotid gland	phenotype	HPO
C1405984	Absent radius	disease	HPO
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human
C1568272	Tendinopathy	disease	BEFREE
C1691215	Penile hypospadias	disease	BEFREE
C1710501	Pleuropulmonary blastoma type I	disease	BEFREE
C1837218	Cleft palate, isolated	disease	CTD_human
C1838608	Radial aplasia	disease	HPO
C1840087	Radial ray hypoplasia	phenotype	HPO
C1845447	Cupped ears (finding)	phenotype	HPO
C1846474	Small thenar eminence	phenotype	HPO
C1848587	Isolated hypoplasia of the right ventricle	disease	BEFREE
C1849089	Broad forehead	phenotype	HPO
C1849314	absence of radius and ulna	phenotype	HPO
C1849538	Delayed eruption of primary teeth	phenotype	HPO
C1850049	Clinodactyly of the 5th finger	disease	HPO
C1851854	Thin dental enamel	phenotype	HPO
C1856136	Conical incisor	phenotype	HPO
C1858036	Periorbital fullness	phenotype	HPO
C1858569	Absence of Stensen duct	phenotype	HPO
C1860614	ULNAR HYPOPLASIA	phenotype	HPO
C1862132	Short ulnae	phenotype	HPO
C1863200	Lacrimal gland hypoplasia	phenotype	HPO
C1867060	Lacrimal Puncta, Absence of	disease	HPO
C1867131	Broad hallux	phenotype	HPO
C1968574	Hypoplastic lacrimal duct	phenotype	HPO
C3714756	Intellectual Disability	group	GENOMICS_ENGLAND
C4020759	Pointed incisor	phenotype	HPO
C4020779	Absence of the parotid gland	phenotype	HPO
C4020787	Subcoronal hypospadias	disease	HPO
C4020888	Epithelial corneal erosions	phenotype	HPO
C4020892	Capuchin ears	disease	HPO
C4021418	Absent proximal phalanx of thumb	phenotype	HPO
C4021564	Hypoplasia of the lacrimal puncta	phenotype	HPO
C4021627	Bilateral triphalangeal thumbs	phenotype	HPO
C4024215	Aplasia of the parotid gland	phenotype	HPO
C4024345	Radial deviation of the 3rd finger	phenotype	HPO
C4024822	Lacrimal gland aplasia	phenotype	HPO
C4025414	Radial club hand	disease	GENOMICS_ENGLAND
C4082168	Partial duplication of thumb phalanx	phenotype	HPO
C4280341	Pointed front tooth	phenotype	HPO
C4280342	Peg shaped front tooth	phenotype	HPO
C4280456	Dysplasia of tooth enamel	phenotype	HPO
C4280457	Defective enamel matrix	phenotype	HPO
C4280538	Curvature of little finger	phenotype	HPO
C4280623	Rotting teeth	phenotype	HPO
C4280674	Agenesis of parotid duct	phenotype	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005104	fibroblast growth factor receptor binding	IDA
GO:0005111	type 2 fibroblast growth factor receptor binding	IPI
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	IDA
GO:0008201	heparin binding	IDA
GO:0042056	chemoattractant activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000132	establishment of mitotic spindle orientation	IEA
GO:0000165	MAPK cascade	TAS
GO:0000187	activation of MAPK activity	IDA
GO:0001525	angiogenesis	IEA
GO:0001656	metanephros development	IEP
GO:0001759	organ induction	IEA
GO:0001823	mesonephros development	IEP
GO:0001974	blood vessel remodeling	IEA
GO:0003338	metanephros morphogenesis	IEA
GO:0007368	determination of left/right symmetry	IEA
GO:0007431	salivary gland development	IMP
GO:0008285	negative regulation of cell population proliferation	IEA
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS
GO:0008589	regulation of smoothened signaling pathway	IEA
GO:0009880	embryonic pattern specification	IEA
GO:0010634	positive regulation of epithelial cell migration	IDA
GO:0010838	positive regulation of keratinocyte proliferation	IDA
GO:0021983	pituitary gland development	IEA
GO:0030538	embryonic genitalia morphogenesis	IEA
GO:0030878	thyroid gland development	IEA
GO:0030916	otic vesicle formation	IEA
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA
GO:0031016	pancreas development	IEA
GO:0031069	hair follicle morphogenesis	IEA
GO:0031076	embryonic camera-type eye development	IEA
GO:0031532	actin cytoskeleton reorganization	IDA
GO:0032355	response to estradiol	IEA
GO:0032496	response to lipopolysaccharide	IEA
GO:0032781	positive regulation of ATPase activity	IDA
GO:0032808	lacrimal gland development	IMP
GO:0032925	regulation of activin receptor signaling pathway	IEA
GO:0034394	protein localization to cell surface	IDA
GO:0035019	somatic stem cell population maintenance	IEA
GO:0042060	wound healing	IDA
GO:0042246	tissue regeneration	IEA
GO:0042475	odontogenesis of dentin-containing tooth	IEA
GO:0042693	muscle cell fate commitment	IEA
GO:0043410	positive regulation of MAPK cascade	IDA
GO:0045596	negative regulation of cell differentiation	IEA
GO:0045739	positive regulation of DNA repair	IDA
GO:0045747	positive regulation of Notch signaling pathway	IEA
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
GO:0046579	positive regulation of Ras protein signal transduction	IDA
GO:0046877	regulation of saliva secretion	IMP
GO:0048146	positive regulation of fibroblast proliferation	IEA
GO:0048536	spleen development	IEA
GO:0048538	thymus development	IDA
GO:0048557	embryonic digestive tract morphogenesis	IEA
GO:0048754	branching morphogenesis of an epithelial tube	IDA
GO:0048807	female genitalia morphogenesis	IEA
GO:0048808	male genitalia morphogenesis	IEA
GO:0050671	positive regulation of lymphocyte proliferation	IDA
GO:0050673	epithelial cell proliferation	IDA
GO:0050674	urothelial cell proliferation	IDA
GO:0050677	positive regulation of urothelial cell proliferation	IDA
GO:0050679	positive regulation of epithelial cell proliferation	IDA
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
GO:0050872	white fat cell differentiation	IEA
GO:0050918	positive chemotaxis	IDA
GO:0050930	induction of positive chemotaxis	IEA
GO:0051145	smooth muscle cell differentiation	IEA
GO:0051549	positive regulation of keratinocyte migration	IDA
GO:0051897	positive regulation of protein kinase B signaling	TAS
GO:0060019	radial glial cell differentiation	ISS
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	NAS
GO:0060174	limb bud formation	IEA
GO:0060428	lung epithelium development	IDA
GO:0060430	lung saccule development	IMP
GO:0060436	bronchiole morphogenesis	IEA
GO:0060447	bud outgrowth involved in lung branching	IDA
GO:0060449	bud elongation involved in lung branching	IEA
GO:0060496	mesenchymal-epithelial cell signaling involved in lung development	IEA
GO:0060510	type II pneumocyte differentiation	IEA
GO:0060513	prostatic bud formation	IEA
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IDA
GO:0060615	mammary gland bud formation	IEA
GO:0060661	submandibular salivary gland formation	IEA
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	IEA
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IEA
GO:0060667	branch elongation involved in salivary gland morphogenesis	IEA
GO:0060879	semicircular canal fusion	IEA
GO:0060915	mesenchymal cell differentiation involved in lung development	IEA
GO:0061033	secretion by lung epithelial cell involved in lung growth	IDA
GO:0061115	lung proximal/distal axis specification	IEA
GO:0070075	tear secretion	IMP
GO:0070352	positive regulation of white fat cell proliferation	IEA
GO:0070371	ERK1 and ERK2 cascade	IDA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA
GO:0070384	Harderian gland development	IEA
GO:0071157	negative regulation of cell cycle arrest	IDA
GO:0071338	positive regulation of hair follicle cell proliferation	IDA
GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IDA
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005623	cell	IEA
GO:0005634	nucleus	IDA
GO:0005886	plasma membrane	IDA
GO:0009986	cell surface	NAS
GO:0009986	cell surface	IDA
GO:0062023	collagen-containing extracellular matrix	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	TAS
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190241	FGFR2 ligand binding and activation	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190370	FGFR1b ligand binding and activation	TAS
R-HSA-190377	FGFR2b ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2033519	Activated point mutants of FGFR2	TAS
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	IEA
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654699	SHC-mediated cascade:FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	TAS
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9607240	FLT3 Signaling	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGF10 mRNA	19933214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]	15618436
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane affects the expression of FGF10 mRNA	18648102
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FGF10 mRNA	20147733
C496492	abrine	abrine results in increased expression of FGF10 mRNA	22595364
D000171	Acrolein	Acrolein results in decreased expression of FGF10 mRNA	18515264
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGF10 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of FGF10 mRNA	24449571
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA	18585445
D001151	Arsenic	Arsenic affects the methylation of FGF10 gene	25304211
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of FGF10 mRNA	26705709
D001194	Asbestos	Asbestos results in decreased expression of FGF10 mRNA	22076105
D001194	Asbestos	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]	15618436
D001194	Asbestos	FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]	15618436
D001194	Asbestos	U 0126 inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]	15618436
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA	18585445
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FGF10 mRNA	30951980
C006780	bisphenol A	bisphenol A results in increased expression of FGF10 mRNA	25594700; 30951980;
C006780	bisphenol A	bisphenol A results in decreased expression of FGF10 mRNA	25181051; 30816183;
C000611646	bisphenol F	bisphenol F results in increased expression of FGF10 mRNA	30951980
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FGF10 mRNA	16644059
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FGF10 mRNA	17805973
C084597	chlorcyclizine	chlorcyclizine results in increased expression of FGF10 mRNA	21058326
D002713	Chlorine	Chlorine results in decreased expression of FGF10 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA	18636392
D002809	Chondroitin Sulfates	Chondroitin Sulfates analog binds to FGF10 protein	12221095
D002809	Chondroitin Sulfates	[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein	15385557
D002809	Chondroitin Sulfates	[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein	14699094
D005576	Colforsin	Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]	12533312; 14975937;
D005576	Colforsin	Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]	12533312; 14975937;
C009160	cyclonite	cyclonite results in decreased expression of FGF10 mRNA	25559034
D003871	Dermatan Sulfate	[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein	15385557
D003871	Dermatan Sulfate	[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein	14699094
D003907	Dexamethasone	Dexamethasone results in decreased expression of FGF10 mRNA	28453788
D003907	Dexamethasone	Dexamethasone results in increased expression of FGF10 mRNA	22733784
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of FGF10 mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FGF10 mRNA]	12205029
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FGF10 mRNA	19464577; 25213187; 26514922; 26948521; 27079746; 28919491;
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FGF10 protein	26514922; 28919491;
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of FGF10 mRNA	15829613
D004041	Dietary Fats	Dietary Fats results in increased expression of FGF10 mRNA	25016146
C058705	diethyl malate	diethyl malate affects the expression of FGF10 mRNA	24814887
D004391	Dust	Dust results in increased secretion of FGF10 protein	29319804
D004958	Estradiol	Estradiol results in decreased expression of FGF10 mRNA	15680359
D004958	Estradiol	Estradiol results in decreased expression of FGF10 protein	15680359
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate affects the expression of FGF10 mRNA	15059950
D017313	Fenretinide	Fenretinide results in decreased expression of FGF10 mRNA	28973697
D005419	Flavonoids	Flavonoids results in increased expression of FGF10 mRNA	18035473
C096856	FTI 277	FTI 277 inhibits the reaction [FGF10 protein results in increased expression of and results in increased activity of ATP1A1 protein]	12804770
D019812	Heparan Sulfate Proteoglycans	Heparan Sulfate Proteoglycans affects the activity of FGF10 protein	16221725
D006493	Heparin	Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein]	15632068
D006497	Heparitin Sulfate	Heparitin Sulfate affects the activity of FGF10 protein	12781692; 12818887;
D006497	Heparitin Sulfate	Heparitin Sulfate analog binds to FGF10 protein	14707131
C545476	incobotulinumtoxinA	incobotulinumtoxinA results in increased expression of FGF10 mRNA	29522793
D007213	Indomethacin	FGF10 protein results in decreased susceptibility to Indomethacin	11052999
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 results in decreased expression of FGF10 mRNA	19524256
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA	23519560
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA	15120970
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of FGF10 mRNA	22076105
C007350	nitrofen	nitrofen results in decreased expression of FGF10 mRNA	11404268
C007350	nitrofen	nitrofen results in decreased expression of FGF10 mRNA	12861530
D016627	Oxidopamine	Oxidopamine results in increased expression of FGF10 mRNA	15303306
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA	18636392
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of FGF10 mRNA]	12242718
D010936	Plant Extracts	Plant Extracts results in decreased expression of FGF10 mRNA	23557933
D011374	Progesterone	Progesterone results in increased expression of FGF10 mRNA	18753603
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FGF10 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in decreased expression of FGF10 mRNA	27029645
D000077185	Resveratrol	Resveratrol results in decreased expression of FGF10 mRNA	23525482; 25338179;
C017947	sodium arsenite	sodium arsenite results in decreased expression of FGF10 mRNA	29301061
C032706	sodium chlorate	sodium chlorate affects the activity of FGF10 protein	12818887
C105686	SU 5402	SU 5402 results in increased expression of FGF10 mRNA	12421715
D000077210	Sunitinib	Sunitinib results in increased expression of FGF10 mRNA	31533062
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF10 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased susceptibility to FGF10 protein	19805408
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGF10 mRNA	26139165
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA	23519560
D013792	Thalidomide	phenyl-N-tert-butylnitrone inhibits the reaction [Thalidomide results in decreased expression of FGF10 mRNA]	12242718
D013792	Thalidomide	Thalidomide results in decreased expression of FGF10 mRNA	12242718; 14713331;
D014118	Toxins, Biological	Toxins, Biological affects the expression of FGF10 mRNA	19682533
D014212	Tretinoin	Tretinoin results in increased expression of FGF10 mRNA	21934132
D014212	Tretinoin	Tretinoin affects the expression of FGF10	10862743
D014212	Tretinoin	Tretinoin results in increased expression of FGF10 mRNA	15328022
C012589	trichostatin A	trichostatin A results in increased expression of FGF10 mRNA	23463510
D014260	Triclosan	Triclosan results in decreased expression of FGF10 mRNA	30510588
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of FGF10 mRNA	19042947
C113580	U 0126	U 0126 inhibits the reaction [FGF10 protein results in increased expression of and results in increased activity of ATP1A1 protein]	12804770
C113580	U 0126	U 0126 inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]	12574212
C113580	U 0126	U 0126 inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]	12574212
C113580	U 0126	U 0126 inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]]	15618436
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of FGF10 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of FGF10 mRNA	18629315

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0225	Disease mutation
KW-0038	Ectodermal dysplasia
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0953	Lacrimo-auriculo-dento-digital syndrome
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR028252	FGF10
IPR002209	Fibroblast_GF_fam
IPR008996	IL1/FGF

PROSITE

PROSITE ID	PROSITE Term
PS00247	HBGF_FGF

Pfam

Pfam ID	Pfam Term
PF00167	FGF

Gene: FGF10

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction