Gene: Tcf21

Basic information

Tag Content
Uniprot ID O35437; Q3U023;
Entrez ID 21412
Genbank protein ID BAE22527.1; BAE34032.1; AAC62513.1; AAB84256.1; BAB27709.1; AAH53525.1; AAC23537.1; BAA23883.1; AAC62531.1;
Genbank nucleotide ID NM_011545.1
Ensembl protein ID ENSMUSP00000053178
Ensembl nucleotide ID ENSMUSG00000045680
Gene name Transcription factor 21
Gene symbol Tcf21
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 12493912
Functional description Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1.
Sequence
MSTGSLSDVE DLQEVEMLDC DSLKVDSNKE FGTSNESTEE GSNCENGSPQ KGRGGLGKRR 60
KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT 120
LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ENDLKEVVTA NRLCGTTAS 179

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificISO
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specificIDA
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIDA
GO:0005515 protein bindingIPI
GO:0042826 histone deacetylase bindingIPI
GO:0043425 bHLH transcription factor bindingISO
GO:0046983 protein dimerization activityIPI
GO:0050681 androgen receptor bindingIPI
GO:0070888 E-box bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0000122 negative regulation of transcription by RNA polymerase IIIDA
GO:0001657 ureteric bud developmentIMP
GO:0001658 branching involved in ureteric bud morphogenesisIMP
GO:0001763 morphogenesis of a branching structureIMP
GO:0001822 kidney developmentIMP
GO:0001944 vasculature developmentIMP
GO:0007530 sex determinationIMP
GO:0007548 sex differentiationIMP
GO:0009887 animal organ morphogenesisIMP
GO:0014707 branchiomeric skeletal muscle developmentIGI
GO:0030855 epithelial cell differentiationIMP
GO:0031063 regulation of histone deacetylationIC
GO:0032835 glomerulus developmentIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0048286 lung alveolus developmentIMP
GO:0048536 spleen developmentIMP
GO:0048557 embryonic digestive tract morphogenesisISS
GO:0048557 embryonic digestive tract morphogenesisISO
GO:0048608 reproductive structure developmentIMP
GO:0048732 gland developmentISS
GO:0048732 gland developmentISO
GO:0060008 Sertoli cell differentiationISS
GO:0060008 Sertoli cell differentiationISO
GO:0060021 roof of mouth developmentIGI
GO:0060425 lung morphogenesisIMP
GO:0060426 lung vasculature developmentIMP
GO:0060435 bronchiole developmentIMP
GO:0060539 diaphragm developmentIGI
GO:0060541 respiratory system developmentIMP
GO:0060766 negative regulation of androgen receptor signaling pathwayIDA
GO:0072162 metanephric mesenchymal cell differentiationIMP
GO:0072277 metanephric glomerular capillary formationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005634 nucleusIC

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

PROSITE

PROSITE ID PROSITE Term
PS50888 BHLH

Pfam

Pfam ID Pfam Term
PF00010 HLH

Protein-protein interaction

Protein-miRNA interaction