| Tag | Content |
|---|---|
| Uniprot ID | O35618; Q9CYG1; |
| Entrez ID | 17248 |
| Genbank protein ID | EDL39662.1; AAB62927.1; BAB30893.1; BAC38879.1; ACB69756.1; EDL39660.1; |
| Genbank nucleotide ID | NM_001302802.1; NM_001302803.1; NM_001302801.1; NM_001302804.1; NM_008575.4; |
| Ensembl protein ID | ENSMUSP00000140609; ENSMUSP00000070411; |
| Ensembl nucleotide ID | ENSMUSG00000054387 |
| Gene name | Protein Mdm4 |
| Gene symbol | Mdm4 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17526734 |
| Functional description | Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform. |
| Sequence | MTSHSTSAQC SASDSACRIS SEQISQVRPK LQLLKILHAA GAQGEVFTMK EVMHYLGQYI 60 MVKQLYDQQE QHMVYCGGDL LGDLLGCQSF SVKDPSPLYD MLRKNLVTSA SINTDAAQTL 120 ALAQDHTMDF PSQDRLKHGA TEYSNPRKRT EEEDTHTLPT SRHKCRDSRA DEDLIEHLSQ 180 DETSRLDLDF EEWDVAGLPW WFLGNLRNNC IPKSNGSTDL QTNQDIGTAI VSDTTDDLWF 240 LNETVSEQLG VGIKVEAANS EQTSEVGKTS NKKTVEVGKD DDLEDSRSLS DDTDVELTSE 300 DEWQCTECKK FNSPSKRYCF RCWALRKDWY SDCSKLTHSL STSNITAIPE KKDNEGIDVP 360 DCRRTISAPV VRPKDGYLKE EKPRFDPCNS VGFLDLAHSS ESQEIISSAR EQTDIFSEQK 420 AETESMEDFQ NVLKPCSLCE KRPRDGNIIH GKTSHLTTCF HCARRLKKSG ASCPACKKEI 480 QLVIKVFIA 489 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0019899 | enzyme binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0002027 | regulation of heart rate | IGI |
| GO:0003170 | heart valve development | IGI |
| GO:0003181 | atrioventricular valve morphogenesis | IGI |
| GO:0003203 | endocardial cushion morphogenesis | IGI |
| GO:0003281 | ventricular septum development | IGI |
| GO:0003283 | atrial septum development | IGI |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | ISS |
| GO:0042177 | negative regulation of protein catabolic process | ISS |
| GO:0042177 | negative regulation of protein catabolic process | ISO |
| GO:0065003 | protein-containing complex assembly | ISO |
| GO:0071157 | negative regulation of cell cycle arrest | IEA |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-2559580 | Oxidative Stress Induced Senescence | IEA |
| R-MMU-2559583 | Cellular Senescence | IEA |
| R-MMU-2559585 | Oncogene Induced Senescence | IEA |
| R-MMU-3700989 | Transcriptional Regulation by TP53 | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-5633007 | Regulation of TP53 Activity | IEA |
| R-MMU-5688426 | Deubiquitination | IEA |
| R-MMU-5689880 | Ub-specific processing proteases | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6804756 | Regulation of TP53 Activity through Phosphorylation | IEA |
| R-MMU-6804757 | Regulation of TP53 Degradation | IEA |
| R-MMU-6804760 | Regulation of TP53 Activity through Methylation | IEA |
| R-MMU-6806003 | Regulation of TP53 Expression and Degradation | IEA |
| R-MMU-69541 | Stabilization of p53 | IEA |
| R-MMU-69563 | p53-Dependent G1 DNA Damage Response | IEA |
| R-MMU-69580 | p53-Dependent G1/S DNA damage checkpoint | IEA |
| R-MMU-69615 | G1/S DNA Damage Checkpoints | IEA |
| R-MMU-69620 | Cell Cycle Checkpoints | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |