| Tag | Content |
|---|---|
| Uniprot ID | O35984 |
| Entrez ID | 18515 |
| Genbank protein ID | AAB82006.1; AAH62147.1; AAB71193.1; AAH10287.1; |
| Genbank nucleotide ID | NM_017463.2 |
| Ensembl protein ID | ENSMUSP00000040464 |
| Ensembl nucleotide ID | ENSMUSG00000034673 |
| Gene name | Pre-B-cell leukemia transcription factor 2 |
| Gene symbol | Pbx2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21982646 |
| Functional description | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity). |
| Sequence | MDERLLGPPP PGGGRGGLGL VGAEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI 60 MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN 120 MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE 180 QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR 240 FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 300 RYKKNIGKFQ EEANIYAVKT AVSVAQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP 360 GLNGDSYPAS QVESLRHSMG PGSYGDNIGG GQIYSPREIR ANGGWQEAVT PSSVTSPTEG 420 PGSVHSDTSN |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISO |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA |
| GO:0003682 | chromatin binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0009954 | proximal/distal pattern formation | IGI |
| GO:0030326 | embryonic limb morphogenesis | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005667 | transcription factor complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|