| Tag | Content |
|---|---|
| Uniprot ID | O43609; D3DNX6; Q6PNE0; |
| Entrez ID | 10252 |
| Genbank protein ID | AAH63856.1; EAX05209.1; AAP20102.1; EAX05210.1; EAX05211.1; AAC39566.1; AAT06102.1; |
| Genbank nucleotide ID | NM_005841.2; NM_001258038.1; XM_017007635.1; NM_001258039.1; NM_199327.2; XM_005262686.1; |
| Ensembl protein ID | ENSP00000480540; ENSP00000481675; ENSP00000377871; ENSP00000498292; ENSP00000343785; |
| Ensembl nucleotide ID | ENSG00000164056 |
| Gene name | Protein sprouty homolog 1 |
| Gene symbol | SPRY1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 28232668 |
| Functional description | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
| Sequence | MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV 60 KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA 120 ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI 180 CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 240 YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 300 NTVYCKLESC PSRGQGKPS 319 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.