Gene: NUAK1

Basic information

Tag Content
Uniprot ID O60285; A7MD39; Q96KA8;
Entrez ID 9891
Genbank protein ID EAW97768.1; BAA25463.2; AAI52463.1; BAB55026.1; BAF82681.1;
Genbank nucleotide ID NM_014840.2
Ensembl protein ID ENSP00000261402
Ensembl nucleotide ID ENSG00000074590
Gene name NUAK family SNF1-like kinase 1
Gene symbol NUAK1
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
Sequence
MEGAAAPVAG DRPDLGLGAP GSPREAVAGA TAALEPRKPH GVKRHHHKHN LKHRYELQET 60
LGKGTYGKVK RATERFSGRV VAIKSIRKDK IKDEQDMVHI RREIEIMSSL NHPHIISIYE 120
VFENKDKIVI IMEYASKGEL YDYISERRRL SERETRHFFR QIVSAVHYCH KNGVVHRDLK 180
LENILLDDNC NIKIADFGLS NLYQKDKFLQ TFCGSPLYAS PEIVNGRPYR GPEVDSWALG 240
VLLYTLVYGT MPFDGFDHKN LIRQISSGEY REPTQPSDAR GLIRWMLMVN PDRRATIEDI 300
ANHWWVNWGY KSSVCDCDAL HDSESPLLAR IIDWHHRSTG LQADTEAKMK GLAKPTTSEV 360
MLERQRSLKK SKKENDFAQS GQDAVPESPS KLSSKRPKGI LKKRSNSEHR SHSTGFIEGV 420
VGPALPSTFK MEQDLCRTGV LLPSSPEAEV PGKLSPKQSA TMPKKGILKK TQQRESGYYS 480
SPERSESSEL LDSNDVMGSS IPSPSPPDPA RVTSHSLSCR RKGILKHSSK YSAGTMDPAL 540
VSPEMPTLES LSEPGVPAEG LSRSYSRPSS VISDDSVLSS DSFDLLDLQE NRPARQRIRS 600
CVSAENFLQI QDFEGLQNRP RPQYLKRYRN RLADSSFSLL TDMDDVTQVY KQALEICSKL 660
N 661

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNUAK1519892E1B9B6Bos taurusPredictionMore>>
1:1 orthologNUAK1481296J9P812Canis lupus familiarisPredictionMore>>
1:1 orthologNUAK1102190764A0A452G5R0Capra hircusPredictionMore>>
1:1 orthologNUAK19891O60285Homo sapiensPredictionMore>>
1:1 orthologNuak177976Q641K5CPOMus musculusPublicationMore>>
1:1 orthologNUAK1742637H2Q6S1Pan troglodytesPredictionMore>>
1:1 orthologNUAK1100523669A0A287AGV4Sus scrofaPredictionMore>>
1:1 orthologNuak1299694D3ZQN8Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0002039 p53 bindingIPI
GO:0004674 protein serine/threonine kinase activityIDA
GO:0004674 protein serine/threonine kinase activityIBA
GO:0004674 protein serine/threonine kinase activityTAS
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingIEA
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0006468 protein phosphorylationIBA
GO:0006468 protein phosphorylationIDA
GO:0006974 cellular response to DNA damage stimulusIEA
GO:0007155 cell adhesionIEA
GO:0030155 regulation of cell adhesionIDA
GO:0035507 regulation of myosin-light-chain-phosphatase activityIDA
GO:0035556 intracellular signal transductionIBA
GO:0042127 regulation of cell population proliferationTAS
GO:1901796 regulation of signal transduction by p53 class mediatorTAS
GO:2000772 regulation of cellular senescenceIDA

GO:Cellular Component

GO ID GO Term Evidence
GO:0001650 fibrillar centerIDA
GO:0005634 nucleusIDA
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmIDA
GO:0005654 nucleoplasmTAS
GO:0005737 cytoplasmIDA
GO:0005737 cytoplasmIBA
GO:0015630 microtubule cytoskeletonIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-212436 Generic Transcription PathwayTAS
R-HSA-3700989 Transcriptional Regulation by TP53TAS
R-HSA-5633007 Regulation of TP53 ActivityTAS
R-HSA-6804756 Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857 RNA Polymerase II TranscriptionTAS
R-HSA-74160 Gene expression (Transcription)TAS

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-0067 ATP-binding
KW-0130 Cell adhesion
KW-0963 Cytoplasm
KW-0227 DNA damage
KW-0418 Kinase
KW-0460 Magnesium
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase
KW-0832 Ubl conjugation

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase

Protein-protein interaction

Protein-miRNA interaction