| Tag | Content |
|---|---|
| Uniprot ID | O60481; B2CNW4; Q14DE5; Q5JY75; |
| Entrez ID | 7547 |
| Genbank protein ID | AAC05594.1; AAI13396.1; ACB30403.1; AAI13394.1; |
| Genbank nucleotide ID | NM_001330661.1; NM_003413.3; |
| Ensembl protein ID | ENSP00000287538; ENSP00000359638; |
| Ensembl nucleotide ID | ENSG00000156925 |
| Gene name | Zinc finger protein ZIC 3 |
| Gene symbol | ZIC3 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. |
| Sequence | MTMLLDGGPQ FPGLGVGSFG APRHHEMPNR EPAGMGLNPF GDSTHAAAAA AAAAAFKLSP 60 AAAHDLSSGQ SSAFTPQGSG YANALGHHHH HHHHHHHTSQ VPSYGGAASA AFNSTREFLF 120 RQRSSGLSEA ASGGGQHGLF AGSASSLHAP AGIPEPPSYL LFPGLHEQGA GHPSPTGHVD 180 NNQVHLGLRG ELFGRADPYR PVASPRTDPY AAGAQFPNYS PMNMNMGVNV AAHHGPGAFF 240 RYMRQPIKQE LSCKWIDEAQ LSRPKKSCDR TFSTMHELVT HVTMEHVGGP EQNNHVCYWE 300 ECPREGKSFK AKYKLVNHIR VHTGEKPFPC PFPGCGKIFA RSENLKIHKR THTGEKPFKC 360 EFEGCDRRFA NSSDRKKHMH VHTSDKPYIC KVCDKSYTHP SSLRKHMKVH ESQGSDSSPA 420 ASSGYESSTP PAIASANSKD TTKTPSAVQT STSHNPGLPP NFNEWYV 467 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.