| Tag | Content |
|---|---|
| Uniprot ID | O60565; Q52LV3; Q8N914; Q8N936; |
| Entrez ID | 26585 |
| Genbank protein ID | BAA84462.1; AAH69525.1; BAC04643.1; AAH93778.1; AAI01612.1; AAP69985.1; AAC39725.1; AAG23891.1; AAF06677.1; |
| Genbank nucleotide ID | NM_013372.6; NM_001191323.1; |
| Ensembl protein ID | ENSP00000498897; ENSP00000498605; ENSP00000488158; ENSP00000498763; ENSP00000498748; ENSP00000300177; ENSP00000453141; ENSP00000323101; |
| Ensembl nucleotide ID | ENSG00000276886; ENSG00000166923; ENSG00000282046; |
| Gene name | Gremlin-1 |
| Gene symbol | GREM1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | CL/P |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26043427 |
| Functional description | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). |
| Sequence | MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR 60 GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 120 QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 180 IDLD 184 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.