CleftGeneDB-Search

Gene: UGDH

Basic information

Tag	Content
Uniprot ID	O60701; B3KUU2; B4DN25; O60589;
Entrez ID	7358
Genbank protein ID	BAG60087.1; CAB75891.1; AAC05135.1; AAC36095.1; CAA07609.1; EAW92937.1; BAG53554.1; AAH22781.1;
Genbank nucleotide ID	NM_001184700.1; NM_003359.3; NM_001184701.1;
Ensembl protein ID	ENSP00000319501; ENSP00000426560; ENSP00000422909; ENSP00000421757;
Ensembl nucleotide ID	ENSG00000109814
Gene name	UDP-glucose 6-dehydrogenase
Gene symbol	UGDH
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Sequence	MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV 60 VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 120 NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 180 GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 240 CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 300 QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 360 GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF 420 KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP 480 KFSLQDPPNK KPKV 494

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
2Q3E
2QG4
3ITK
3KHU
3PRJ
3PTZ
3TDK
3TF5
4EDF
4RJT
5TJH
5VR8
5W4X
6C4J
6C4K
6C58
6C5A
6C5Z
2Q3E
2QG4
3ITK
3KHU
3PRJ
3PTZ
3TDK
3TF5
4EDF
4RJT
5TJH
5VR8
5W4X
6C4J

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	UGDH	281564	P12378		Bos taurus	Prediction	More>>
1:1 ortholog	UGDH	479107	E2R311		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	UGDH	102171772	A0A452G134		Capra hircus	Prediction	More>>
1:1 ortholog	UGDH	7358	O60701		Homo sapiens	Prediction	More>>
1:1 ortholog	Ugdh	22235	O70475	CPO	Mus musculus	Publication	More>>
1:1 ortholog	UGDH	471171	H2QPC9		Pan troglodytes	Prediction	More>>
1:1 ortholog	UGDH	100627727	I3LIM2		Sus scrofa	Prediction	More>>
1:1 ortholog	Ugdh		G3V6C4		Rattus norvegicus	Prediction	More>>
1:1 ortholog	ugdh	116991	A8WGP7		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
NCI-TCGA novel	p.Ile4Asn	missense variant	-	NC_000004.12:g.39521502A>T	NCI-TCGA
rs767490233	p.Lys6Arg	missense variant	-	NC_000004.12:g.39521496T>C	ExAC,gnomAD
NCI-TCGA novel	p.Lys6Asn	missense variant	-	NC_000004.12:g.39521495C>A	NCI-TCGA
rs761771847	p.Ile7Leu	missense variant	-	NC_000004.12:g.39521494T>G	ExAC,gnomAD
rs761771847	p.Ile7Phe	missense variant	-	NC_000004.12:g.39521494T>A	ExAC,gnomAD
rs773970612	p.Cys9Phe	missense variant	-	NC_000004.12:g.39521487C>A	ExAC,gnomAD
rs759610662	p.Gly13Asp	missense variant	-	NC_000004.12:g.39521475C>T	ExAC,gnomAD
rs369608407	p.Tyr14Cys	missense variant	-	NC_000004.12:g.39521472T>C	ESP,ExAC,gnomAD
rs369608407	p.Tyr14Cys	missense variant	-	NC_000004.12:g.39521472T>C	NCI-TCGA
rs773827332	p.Cys20Tyr	missense variant	-	NC_000004.12:g.39521454C>T	ExAC,TOPMed,gnomAD
rs772663434	p.Ile23Val	missense variant	-	NC_000004.12:g.39521446T>C	ExAC,gnomAD
rs1306655122	p.Ala24Ser	missense variant	-	NC_000004.12:g.39521443C>A	TOPMed
rs947588957	p.Met26Thr	missense variant	-	NC_000004.12:g.39521436A>G	TOPMed,gnomAD
rs947588957	p.Met26Lys	missense variant	-	NC_000004.12:g.39521436A>T	TOPMed,gnomAD
rs779084607	p.Arg31Lys	missense variant	-	NC_000004.12:g.39521421C>T	ExAC,gnomAD
rs1025047581	p.Val32Ile	missense variant	-	NC_000004.12:g.39521419C>T	TOPMed
rs145763615	p.Thr33Met	missense variant	-	NC_000004.12:g.39521415G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val34Ile	missense variant	-	NC_000004.12:g.39521413C>T	NCI-TCGA
rs1299204864	p.Val35Ile	missense variant	-	NC_000004.12:g.39521410C>T	gnomAD
rs928688123	p.Asn38Ser	missense variant	-	NC_000004.12:g.39521400T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Asn38Asp	missense variant	-	NC_000004.12:g.39521401T>C	NCI-TCGA
COSM258308	p.Glu39Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000004.12:g.39521398C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ile42Asn	missense variant	-	NC_000004.12:g.39521388A>T	NCI-TCGA
rs1253201158	p.Asn43Ser	missense variant	-	NC_000004.12:g.39521385T>C	TOPMed
rs749975104	p.Ala44Val	missense variant	-	NC_000004.12:g.39521382G>A	ExAC,TOPMed,gnomAD
rs1388970611	p.Asn46Asp	missense variant	-	NC_000004.12:g.39521377T>C	gnomAD
NCI-TCGA novel	p.Ser47Tyr	missense variant	-	NC_000004.12:g.39521373G>T	NCI-TCGA
rs763792474	p.Leu50Val	missense variant	-	NC_000004.12:g.39521365G>C	ExAC,gnomAD
rs762867803	p.Ile52Val	missense variant	-	NC_000004.12:g.39521359T>C	ExAC,gnomAD
rs752500252	p.Pro55Ser	missense variant	-	NC_000004.12:g.39514184G>A	ExAC,gnomAD
rs765143424	p.Glu59Asp	missense variant	-	NC_000004.12:g.39514170T>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu59Lys	missense variant	-	NC_000004.12:g.39514172C>T	NCI-TCGA
rs760920354	p.Val61Ile	missense variant	-	NC_000004.12:g.39514166C>T	ExAC,gnomAD
NCI-TCGA novel	p.Ser63Phe	missense variant	-	NC_000004.12:g.39514159G>A	NCI-TCGA
rs200059198	p.Arg65Ter	stop gained	-	NC_000004.12:g.39514154G>A	ExAC,TOPMed,gnomAD
rs767697391	p.Arg65Gln	missense variant	-	NC_000004.12:g.39514153C>T	ExAC,TOPMed,gnomAD
rs140219602	p.Leu69Ile	missense variant	-	NC_000004.12:g.39514142G>T	ESP,ExAC,gnomAD
COSM1231666	p.Phe71Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39514134A>C	NCI-TCGA Cosmic
rs769243823	p.Ser72Pro	missense variant	-	NC_000004.12:g.39514133A>G	ExAC,TOPMed,gnomAD
rs765734647	p.Ser72LeuPheSerTerUnkUnk	frameshift	-	NC_000004.12:g.39514133A>-	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser72Tyr	missense variant	-	NC_000004.12:g.39514132G>T	NCI-TCGA
rs1446226540	p.Thr73Ser	missense variant	-	NC_000004.12:g.39514129G>C	gnomAD
rs775776023	p.Asn74Ser	missense variant	-	NC_000004.12:g.39514126T>C	ExAC,TOPMed,gnomAD
rs1489618454	p.Asp76Tyr	missense variant	-	NC_000004.12:g.39514121C>A	gnomAD
COSM6167101	p.Asp76Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39514121C>T	NCI-TCGA Cosmic
rs745515782	p.Ala78Thr	missense variant	-	NC_000004.12:g.39514115C>T	ExAC,TOPMed,gnomAD
rs776324809	p.Ile79Val	missense variant	-	NC_000004.12:g.39514112T>C	ExAC,gnomAD
NCI-TCGA novel	p.Glu81Ter	stop gained	-	NC_000004.12:g.39514106C>A	NCI-TCGA
NCI-TCGA novel	p.Ala82Thr	missense variant	-	NC_000004.12:g.39514103C>T	NCI-TCGA
rs777181206	p.Asp83Asn	missense variant	-	NC_000004.12:g.39514100C>T	ExAC,gnomAD
rs777181206	p.Asp83His	missense variant	-	NC_000004.12:g.39514100C>G	ExAC,gnomAD
rs1260873652	p.Asp83Gly	missense variant	-	NC_000004.12:g.39514099T>C	TOPMed
rs187460266	p.Val85Ile	missense variant	-	NC_000004.12:g.39514094C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs187460266	p.Val85Leu	missense variant	-	NC_000004.12:g.39514094C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser88Tyr	missense variant	-	NC_000004.12:g.39514084G>T	NCI-TCGA
rs113565151	p.Asn90Thr	missense variant	-	NC_000004.12:g.39510857T>G	ExAC,gnomAD
rs113565151	p.Asn90Ser	missense variant	-	NC_000004.12:g.39510857T>C	ExAC,gnomAD
rs1389276038	p.Pro92Ser	missense variant	-	NC_000004.12:g.39510852G>A	gnomAD
rs1400737927	p.Thr93Arg	missense variant	-	NC_000004.12:g.39510848G>C	gnomAD
rs1172635390	p.Lys94Asn	missense variant	-	NC_000004.12:g.39510844T>A	gnomAD
COSM4124605	p.Thr95Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39510842G>T	NCI-TCGA Cosmic
rs375953801	p.Tyr96Cys	missense variant	-	NC_000004.12:g.39510839T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Met98Thr	missense variant	-	NC_000004.12:g.39510833A>G	NCI-TCGA
rs1428096648	p.Lys100Asn	missense variant	-	NC_000004.12:g.39510826T>G	gnomAD
rs779742282	p.Arg102Trp	missense variant	-	NC_000004.12:g.39510822G>A	ExAC,gnomAD
rs757450293	p.Arg102Gln	missense variant	-	NC_000004.12:g.39510821C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg102Leu	missense variant	-	NC_000004.12:g.39510821C>A	NCI-TCGA
rs1420419492	p.Ala104Val	missense variant	-	NC_000004.12:g.39510815G>A	TOPMed,gnomAD
rs751736713	p.Lys107Ter	stop gained	-	NC_000004.12:g.39510807T>A	ExAC,gnomAD
rs568964757	p.Ala111Val	missense variant	-	NC_000004.12:g.39510794G>A	1000Genomes,ExAC,gnomAD
rs202045254	p.Arg115His	missense variant	-	NC_000004.12:g.39510782C>T	ESP,ExAC,TOPMed,gnomAD
rs140504706	p.Arg115Cys	missense variant	-	NC_000004.12:g.39510783G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs202045254	p.Arg115Leu	missense variant	-	NC_000004.12:g.39510782C>A	ESP,ExAC,TOPMed,gnomAD
rs1263944470	p.Val117Leu	missense variant	-	NC_000004.12:g.39510777C>G	gnomAD
rs1221194267	p.Gln118Arg	missense variant	-	NC_000004.12:g.39510773T>C	TOPMed,gnomAD
rs1221194267	p.Gln118Leu	missense variant	-	NC_000004.12:g.39510773T>A	TOPMed,gnomAD
rs1371247878	p.Asn119Asp	missense variant	-	NC_000004.12:g.39510771T>C	gnomAD
rs766669367	p.Asn121Asp	missense variant	-	NC_000004.12:g.39510765T>C	ExAC,TOPMed,gnomAD
rs766669367	p.Asn121His	missense variant	-	NC_000004.12:g.39510765T>G	ExAC,TOPMed,gnomAD
rs1333300842	p.Lys124Glu	missense variant	-	NC_000004.12:g.39510756T>C	gnomAD
rs760304916	p.Ile125Met	missense variant	-	NC_000004.12:g.39510751A>C	ExAC,gnomAD
rs1405123351	p.Thr127Pro	missense variant	-	NC_000004.12:g.39510747T>G	gnomAD
rs111337616	p.Val132Ile	missense variant	-	NC_000004.12:g.39510732C>T	TOPMed
rs771593403	p.Val132Gly	missense variant	-	NC_000004.12:g.39510731A>C	ExAC,gnomAD
rs111337616	p.Val132Phe	missense variant	-	NC_000004.12:g.39510732C>A	TOPMed
rs761454872	p.Pro133Leu	missense variant	-	NC_000004.12:g.39510728G>A	ExAC,TOPMed,gnomAD
COSM265754	p.Pro133Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39510729G>A	NCI-TCGA Cosmic
rs1439780087	p.Val134Ala	missense variant	-	NC_000004.12:g.39510725A>G	gnomAD
rs1439780087	p.Val134Gly	missense variant	-	NC_000004.12:g.39510725A>C	gnomAD
rs768674438	p.Arg135Trp	missense variant	-	NC_000004.12:g.39510723G>A	ExAC,gnomAD
rs1182319939	p.Arg135Gln	missense variant	-	NC_000004.12:g.39510722C>T	gnomAD
NCI-TCGA novel	p.Glu138Gly	missense variant	-	NC_000004.12:g.39510713T>C	NCI-TCGA
rs749259185	p.Ile140Val	missense variant	-	NC_000004.12:g.39510708T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile140Leu	missense variant	-	NC_000004.12:g.39510708T>G	NCI-TCGA
rs769545929	p.Arg141His	missense variant	-	NC_000004.12:g.39510704C>T	ExAC,TOPMed,gnomAD
rs115137663	p.Arg141Cys	missense variant	-	NC_000004.12:g.39510705G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs769545929	p.Arg141Leu	missense variant	-	NC_000004.12:g.39510704C>A	ExAC,TOPMed,gnomAD
rs747242250	p.Arg142Cys	missense variant	-	NC_000004.12:g.39510702G>A	ExAC,TOPMed,gnomAD
rs368044471	p.Arg142His	missense variant	-	NC_000004.12:g.39510701C>T	ExAC,gnomAD
rs1355977627	p.Ile143Val	missense variant	-	NC_000004.12:g.39510699T>C	gnomAD
rs1450410640	p.Asp145Val	missense variant	-	NC_000004.12:g.39510692T>A	gnomAD
rs1381741430	p.Ala146Gly	missense variant	-	NC_000004.12:g.39510689G>C	gnomAD
COSM6100002	p.Ala146Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39510689G>A	NCI-TCGA Cosmic
rs752737840	p.Thr148Ala	missense variant	-	NC_000004.12:g.39510684T>C	ExAC,gnomAD
rs778991709	p.Asn151Thr	missense variant	-	NC_000004.12:g.39510674T>G	ExAC,gnomAD
rs754301626	p.Leu154Phe	missense variant	-	NC_000004.12:g.39510664T>G	ExAC,gnomAD
NCI-TCGA novel	p.Leu154Val	missense variant	-	NC_000004.12:g.39510666A>C	NCI-TCGA
rs1381665298	p.Gln155Ter	stop gained	-	NC_000004.12:g.39510663G>A	gnomAD
rs766757605	p.Gln155Arg	missense variant	-	NC_000004.12:g.39510662T>C	ExAC,gnomAD
rs375062099	p.Asn159Ser	missense variant	-	NC_000004.12:g.39510540T>C	ESP,ExAC,TOPMed,gnomAD
rs772235942	p.Pro160Ser	missense variant	-	NC_000004.12:g.39510538G>A	ExAC,gnomAD
rs1427070347	p.Ala164Glu	missense variant	-	NC_000004.12:g.39510525G>T	gnomAD
rs748387130	p.Gly166Ter	stop gained	-	NC_000004.12:g.39510520C>A	ExAC,gnomAD
rs755113560	p.Thr167Ile	missense variant	-	NC_000004.12:g.39510516G>A	ExAC,gnomAD
rs908289507	p.Lys170Arg	missense variant	-	NC_000004.12:g.39510507T>C	gnomAD
rs1288573479	p.Asp171Asn	missense variant	-	NC_000004.12:g.39510505C>T	gnomAD
NCI-TCGA novel	p.Asn174Ser	missense variant	-	NC_000004.12:g.39510495T>C	NCI-TCGA
rs756467468	p.Pro175Thr	missense variant	-	NC_000004.12:g.39510493G>T	ExAC,gnomAD
rs1305524531	p.Asp176Glu	missense variant	-	NC_000004.12:g.39510488G>C	gnomAD
rs1223728130	p.Asp176Gly	missense variant	-	NC_000004.12:g.39510489T>C	gnomAD
rs768014546	p.Ile180Thr	missense variant	-	NC_000004.12:g.39510477A>G	ExAC,gnomAD
rs527756813	p.Gly182Arg	missense variant	-	NC_000004.12:g.39510472C>T	1000Genomes,ExAC,gnomAD
rs948466547	p.Thr185Ile	missense variant	-	NC_000004.12:g.39510462G>A	TOPMed
COSM6167102	p.Pro186Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39510460G>C	NCI-TCGA Cosmic
rs1282156495	p.Gln189Arg	missense variant	-	NC_000004.12:g.39510450T>C	TOPMed
rs751260541	p.Arg190Ile	missense variant	-	NC_000004.12:g.39510447C>A	ExAC,TOPMed,gnomAD
rs763685293	p.Ala191Ser	missense variant	-	NC_000004.12:g.39510445C>A	ExAC,TOPMed,gnomAD
rs894232451	p.Gln193Ter	stop gained	-	NC_000004.12:g.39510439G>A	TOPMed
rs144192248	p.Ala194Val	missense variant	-	NC_000004.12:g.39510435G>A	ESP,ExAC,gnomAD
rs1443799790	p.Ala194Thr	missense variant	-	NC_000004.12:g.39510436C>T	gnomAD
rs1171919565	p.Leu195Pro	missense variant	-	NC_000004.12:g.39510432A>G	gnomAD
rs775468206	p.Cys196Trp	missense variant	-	NC_000004.12:g.39510428A>C	ExAC,gnomAD
rs1427393045	p.Val198Ile	missense variant	-	NC_000004.12:g.39510424C>T	gnomAD
rs1463142555	p.Glu200Asp	missense variant	-	NC_000004.12:g.39510416C>A	TOPMed
rs1199000393	p.His201Arg	missense variant	-	NC_000004.12:g.39510414T>C	TOPMed,gnomAD
rs765048353	p.His201Gln	missense variant	-	NC_000004.12:g.39510413G>T	ExAC,TOPMed,gnomAD
rs1054657510	p.Val203Ile	missense variant	-	NC_000004.12:g.39510409C>T	TOPMed
rs933655472	p.Arg205Thr	missense variant	-	NC_000004.12:g.39510402C>G	gnomAD
rs778486297	p.Glu206Gly	missense variant	-	NC_000004.12:g.39510399T>C	TOPMed
rs776235593	p.Ile208Phe	missense variant	-	NC_000004.12:g.39510394T>A	ExAC,gnomAD
rs770721281	p.Thr211Asn	missense variant	-	NC_000004.12:g.39510384G>T	ExAC,gnomAD
rs1319762440	p.Asn212Asp	missense variant	-	NC_000004.12:g.39510382T>C	gnomAD
rs774610502	p.Ser216Ter	stop gained	-	NC_000004.12:g.39510369G>T	ExAC,gnomAD
rs1352368485	p.Ala223Glu	missense variant	-	NC_000004.12:g.39509903G>T	gnomAD
NCI-TCGA novel	p.Leu227Val	missense variant	-	NC_000004.12:g.39509892G>C	NCI-TCGA
rs1450230376	p.Ala228Ser	missense variant	-	NC_000004.12:g.39509889C>A	TOPMed
rs1243008711	p.Gln229Lys	missense variant	-	NC_000004.12:g.39509886G>T	gnomAD
NCI-TCGA novel	p.Gln229His	missense variant	-	NC_000004.12:g.39509884C>A	NCI-TCGA
rs763881954	p.Ile234Val	missense variant	-	NC_000004.12:g.39509871T>C	ExAC,gnomAD
rs1396973439	p.Ile237Met	missense variant	-	NC_000004.12:g.39509860T>C	gnomAD
rs1333993203	p.Ile237Val	missense variant	-	NC_000004.12:g.39509862T>C	TOPMed,gnomAD
rs1287358288	p.Leu240Met	missense variant	-	NC_000004.12:g.39509853G>T	gnomAD
rs1453094335	p.Thr244Ala	missense variant	-	NC_000004.12:g.39509841T>C	gnomAD
NCI-TCGA novel	p.Thr244Arg	missense variant	-	NC_000004.12:g.39509840G>C	NCI-TCGA
rs139554286	p.Asp247Val	missense variant	-	NC_000004.12:g.39509831T>A	ESP,ExAC,TOPMed
rs1413039249	p.Asp247Glu	missense variant	-	NC_000004.12:g.39509830A>T	TOPMed,gnomAD
rs1457035532	p.Asp247Asn	missense variant	-	NC_000004.12:g.39509832C>T	gnomAD
rs1159158609	p.Ala252Thr	missense variant	-	NC_000004.12:g.39509817C>T	gnomAD
rs1186496501	p.Ile255Thr	missense variant	-	NC_000004.12:g.39509807A>G	gnomAD
rs759328854	p.Met257Lys	missense variant	-	NC_000004.12:g.39509801A>T	ExAC,TOPMed,gnomAD
COSM733508	p.Gln259His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39509794C>A	NCI-TCGA Cosmic
rs766146242	p.Ala268Ser	missense variant	-	NC_000004.12:g.39509769C>A	ExAC,gnomAD
rs760508476	p.Ser269Asn	missense variant	-	NC_000004.12:g.39509765C>T	ExAC,gnomAD
NCI-TCGA novel	p.Ser275Asn	missense variant	-	NC_000004.12:g.39508648C>T	NCI-TCGA
rs1273664472	p.Gln278Arg	missense variant	-	NC_000004.12:g.39508639T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Val281Gly	missense variant	-	NC_000004.12:g.39508630A>C	NCI-TCGA
rs1423831672	p.Asn283Asp	missense variant	-	NC_000004.12:g.39508625T>C	gnomAD
rs985297316	p.Cys288Tyr	missense variant	-	NC_000004.12:g.39508609C>T	gnomAD
rs776883283	p.Ala290Val	missense variant	-	NC_000004.12:g.39508603G>A	ExAC,gnomAD
rs199986130	p.Arg298Cys	missense variant	-	NC_000004.12:g.39508580G>A	ExAC,TOPMed,gnomAD
rs968491131	p.Arg298His	missense variant	-	NC_000004.12:g.39508579C>T	TOPMed,gnomAD
rs1464295100	p.Ile304Thr	missense variant	-	NC_000004.12:g.39505744A>G	gnomAD
rs1239397498	p.Ile304Val	missense variant	-	NC_000004.12:g.39505745T>C	gnomAD
rs1159032166	p.Met306Arg	missense variant	-	NC_000004.12:g.39505738A>C	TOPMed
NCI-TCGA novel	p.Asp308Ala	missense variant	-	NC_000004.12:g.39505732T>G	NCI-TCGA
NCI-TCGA novel	p.Asp308Tyr	missense variant	-	NC_000004.12:g.39505733C>A	NCI-TCGA
rs1333198828	p.Tyr309His	missense variant	-	NC_000004.12:g.39505730A>G	gnomAD
NCI-TCGA novel	p.Arg312Ser	missense variant	-	NC_000004.12:g.39505719C>A	NCI-TCGA
rs1317015589	p.Arg313Lys	missense variant	-	NC_000004.12:g.39505717C>T	TOPMed
NCI-TCGA novel	p.Arg313Met	missense variant	-	NC_000004.12:g.39505717C>A	NCI-TCGA
rs775162839	p.Arg317Gln	missense variant	-	NC_000004.12:g.39505705C>T	ExAC,TOPMed,gnomAD
rs779173046	p.Arg317Trp	missense variant	-	NC_000004.12:g.39505706G>A	ExAC,gnomAD
NCI-TCGA novel	p.Asp320ValPheSerTerUnk	frameshift	-	NC_000004.12:g.39505693_39505696CTAT>-	NCI-TCGA
NCI-TCGA novel	p.Thr327Ser	missense variant	-	NC_000004.12:g.39505675G>C	NCI-TCGA
rs1287204329	p.Lys329Asn	missense variant	-	NC_000004.12:g.39505668C>G	TOPMed
rs755687279	p.Ile333Leu	missense variant	-	NC_000004.12:g.39505658T>G	ExAC,gnomAD
NCI-TCGA novel	p.Ile333Phe	missense variant	-	NC_000004.12:g.39505658T>A	NCI-TCGA
rs973256107	p.Gly335Arg	missense variant	-	NC_000004.12:g.39505652C>T	gnomAD
rs1203959093	p.Thr342Ser	missense variant	-	NC_000004.12:g.39505630G>C	TOPMed
rs1283606237	p.Asp344Asn	missense variant	-	NC_000004.12:g.39505625C>T	TOPMed
COSM3917751	p.Arg346Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39505618C>T	NCI-TCGA Cosmic
rs1290408243	p.Ser350Asn	missense variant	-	NC_000004.12:g.39505359C>T	gnomAD
rs1479782965	p.Met358Thr	missense variant	-	NC_000004.12:g.39505335A>G	TOPMed
COSM6167103	p.Glu360Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39505330C>T	NCI-TCGA Cosmic
rs769271659	p.Ala362Thr	missense variant	-	NC_000004.12:g.39505324C>T	ExAC,gnomAD
rs10010387	p.His363Arg	missense variant	-	NC_000004.12:g.39505320T>C	ExAC,TOPMed,gnomAD
rs543523320	p.Leu364Val	missense variant	-	NC_000004.12:g.39505318G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs746926346	p.His365Leu	missense variant	-	NC_000004.12:g.39505314T>A	ExAC,gnomAD
rs1423124119	p.His365Gln	missense variant	-	NC_000004.12:g.39505313A>T	gnomAD
NCI-TCGA novel	p.Tyr367Cys	missense variant	-	NC_000004.12:g.39505308T>C	NCI-TCGA
NCI-TCGA novel	p.Pro369Arg	missense variant	-	NC_000004.12:g.39505302G>C	NCI-TCGA
NCI-TCGA novel	p.Pro369Leu	missense variant	-	NC_000004.12:g.39505302G>A	NCI-TCGA
rs1171698535	p.Lys370Glu	missense variant	-	NC_000004.12:g.39505300T>C	TOPMed,gnomAD
rs777622665	p.Lys370Thr	missense variant	-	NC_000004.12:g.39505299T>G	ExAC,gnomAD
COSM1429637	p.Val371TyrPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000004.12:g.39505298T>-	NCI-TCGA Cosmic
rs1370929186	p.Val378Met	missense variant	-	NC_000004.12:g.39505276C>T	TOPMed
rs1461226039	p.Ser381Tyr	missense variant	-	NC_000004.12:g.39505266G>T	TOPMed
COSM420592	p.Ser381Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39505266G>A	NCI-TCGA Cosmic
rs766743798	p.His382Gln	missense variant	-	NC_000004.12:g.39505262A>C	ExAC
rs750465337	p.Gly384Val	missense variant	-	NC_000004.12:g.39505257C>A	ExAC,gnomAD
rs182948898	p.Gly384Arg	missense variant	-	NC_000004.12:g.39505258C>G	1000Genomes,gnomAD
rs182948898	p.Gly384Ser	missense variant	-	NC_000004.12:g.39505258C>T	1000Genomes,gnomAD
rs372994324	p.Val385Ile	missense variant	-	NC_000004.12:g.39505255C>T	ESP,ExAC,TOPMed,gnomAD
rs762313199	p.Ser386Ter	stop gained	-	NC_000004.12:g.39505251G>T	ExAC,gnomAD
rs1407273373	p.Asp389Gly	missense variant	-	NC_000004.12:g.39505242T>C	TOPMed
rs774785564	p.Gln390His	missense variant	-	NC_000004.12:g.39505238T>G	ExAC,gnomAD
rs113094436	p.Arg393Trp	missense variant	-	NC_000004.12:g.39504503G>A	1000Genomes,ExAC,gnomAD
rs1481372223	p.Arg393Gln	missense variant	-	NC_000004.12:g.39504502C>T	gnomAD
rs1420139288	p.Leu394Pro	missense variant	-	NC_000004.12:g.39504499A>G	gnomAD
rs752083244	p.Val395Met	missense variant	-	NC_000004.12:g.39504497C>T	ExAC,TOPMed,gnomAD
rs763473129	p.Lys399Thr	missense variant	-	NC_000004.12:g.39504484T>G	ExAC,TOPMed,gnomAD
rs763473129	p.Lys399Arg	missense variant	-	NC_000004.12:g.39504484T>C	ExAC,TOPMed,gnomAD
rs770011021	p.Asp400Val	missense variant	-	NC_000004.12:g.39504481T>A	TOPMed
rs1238675111	p.Asp400Asn	missense variant	-	NC_000004.12:g.39504482C>T	TOPMed,gnomAD
rs770011021	p.Asp400Gly	missense variant	-	NC_000004.12:g.39504481T>C	TOPMed
rs899094826	p.Tyr402His	missense variant	-	NC_000004.12:g.39504476A>G	TOPMed
rs753003368	p.Asp406Gly	missense variant	-	NC_000004.12:g.39504463T>C	ExAC,gnomAD
rs765591985	p.Gly407Asp	missense variant	-	NC_000004.12:g.39504460C>T	ExAC,TOPMed,gnomAD
rs776207068	p.Ala408Thr	missense variant	-	NC_000004.12:g.39504458C>T	ExAC,TOPMed,gnomAD
rs776207068	p.Ala408Ser	missense variant	-	NC_000004.12:g.39504458C>A	ExAC,TOPMed,gnomAD
rs770456604	p.Ala410Ser	missense variant	-	NC_000004.12:g.39504452C>A	ExAC,TOPMed,gnomAD
COSM3674176	p.Ile413Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39504442A>G	NCI-TCGA Cosmic
rs1361014385	p.Glu416Ter	stop gained	-	NC_000004.12:g.39504434C>A	gnomAD
rs141970383	p.Glu416Asp	missense variant	-	NC_000004.12:g.39504432C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Trp417Cys	missense variant	-	NC_000004.12:g.39504429C>A	NCI-TCGA
NCI-TCGA novel	p.Trp417Leu	missense variant	-	NC_000004.12:g.39504430C>A	NCI-TCGA
rs1437820312	p.Met419Val	missense variant	-	NC_000004.12:g.39504425T>C	gnomAD
rs371662600	p.Met419Ile	missense variant	-	NC_000004.12:g.39504423C>T	ESP,ExAC,TOPMed,gnomAD
COSM286270	p.Lys421Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39504417C>A	NCI-TCGA Cosmic
rs370295255	p.Glu422Gly	missense variant	-	NC_000004.12:g.39503984T>C	ESP,ExAC,TOPMed,gnomAD
rs772787684	p.Glu422Lys	missense variant	-	NC_000004.12:g.39503985C>T	ExAC,gnomAD
rs922278383	p.Glu426Lys	missense variant	-	NC_000004.12:g.39503973C>T	gnomAD
rs148161041	p.Arg427Cys	missense variant	-	NC_000004.12:g.39503970G>A	ESP,ExAC,TOPMed,gnomAD
rs768474926	p.Arg427His	missense variant	-	NC_000004.12:g.39503969C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His429Ter	frameshift	-	NC_000004.12:g.39503952_39503964GCATTTTTTTATG>-	NCI-TCGA
rs147122976	p.Lys431Arg	missense variant	-	NC_000004.12:g.39503957T>C	ESP,ExAC,TOPMed,gnomAD
rs774133578	p.Met432CysPheSerTerUnk	frameshift	-	NC_000004.12:g.39503955T>-	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Met432AsnPheSerTerUnkUnk	frameshift	-	NC_000004.12:g.39503954_39503955insT	NCI-TCGA
rs1318866802	p.Pro435Ala	missense variant	-	NC_000004.12:g.39503946G>C	gnomAD
rs1162365973	p.Phe437Ser	missense variant	-	NC_000004.12:g.39503939A>G	gnomAD
rs1388307521	p.Phe437Val	missense variant	-	NC_000004.12:g.39503940A>C	gnomAD
rs754871857	p.Ile438Val	missense variant	-	NC_000004.12:g.39503937T>C	ExAC,TOPMed,gnomAD
rs777823955	p.Asp440Asn	missense variant	-	NC_000004.12:g.39503931C>T	ExAC,gnomAD
rs201894374	p.Arg442Trp	missense variant	-	NC_000004.12:g.39503925G>A	1000Genomes,gnomAD
rs1195945550	p.Arg443Cys	missense variant	-	NC_000004.12:g.39503922G>A	gnomAD
rs1053767552	p.Arg443His	missense variant	-	NC_000004.12:g.39503921C>T	TOPMed
rs1053767552	p.Arg443His	missense variant	-	NC_000004.12:g.39503921C>T	NCI-TCGA Cosmic
rs748628569	p.Val444Leu	missense variant	-	NC_000004.12:g.39503919C>G	ExAC,gnomAD
COSM1485950	p.Asp446Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39503913C>T	NCI-TCGA Cosmic
rs1259165663	p.Gly447Arg	missense variant	-	NC_000004.12:g.39503910C>T	TOPMed
NCI-TCGA novel	p.Leu448Arg	missense variant	-	NC_000004.12:g.39503906A>C	NCI-TCGA
rs779324355	p.His449Leu	missense variant	-	NC_000004.12:g.39503903T>A	ExAC,TOPMed,gnomAD
rs137877647	p.Asn450Thr	missense variant	-	NC_000004.12:g.39503900T>G	ESP,TOPMed,gnomAD
rs137877647	p.Asn450Ser	missense variant	-	NC_000004.12:g.39503900T>C	ESP,TOPMed,gnomAD
rs1256363149	p.Glu451Val	missense variant	-	NC_000004.12:g.39503897T>A	gnomAD
rs766784095	p.Gln453His	missense variant	-	NC_000004.12:g.39503890T>G	ExAC,gnomAD
rs371132377	p.Gln453Ter	stop gained	-	NC_000004.12:g.39503892G>A	ESP,ExAC,gnomAD
rs755764491	p.Ile455Thr	missense variant	-	NC_000004.12:g.39503885A>G	ExAC,TOPMed,gnomAD
rs934953491	p.Ile455Val	missense variant	-	NC_000004.12:g.39503886T>C	TOPMed
rs755764491	p.Ile455Thr	missense variant	-	NC_000004.12:g.39503885A>G	NCI-TCGA,NCI-TCGA Cosmic
rs895364082	p.Ile459Thr	missense variant	-	NC_000004.12:g.39500252A>G	TOPMed,gnomAD
rs749809838	p.Thr461Lys	missense variant	-	NC_000004.12:g.39500246G>T	ExAC,TOPMed,gnomAD
rs749809838	p.Thr461Ile	missense variant	-	NC_000004.12:g.39500246G>A	ExAC,TOPMed,gnomAD
rs749809838	p.Thr461Arg	missense variant	-	NC_000004.12:g.39500246G>C	ExAC,TOPMed,gnomAD
rs1048654784	p.Ile462Val	missense variant	-	NC_000004.12:g.39500244T>C	TOPMed,gnomAD
rs750080424	p.Val466Met	missense variant	-	NC_000004.12:g.39500232C>T	NCI-TCGA
rs750080424	p.Val466Leu	missense variant	-	NC_000004.12:g.39500232C>A	ExAC,gnomAD
rs750080424	p.Val466Met	missense variant	-	NC_000004.12:g.39500232C>T	ExAC,gnomAD
rs767319348	p.Lys469Glu	missense variant	-	NC_000004.12:g.39500223T>C	ExAC,TOPMed,gnomAD
rs767319348	p.Lys469Gln	missense variant	-	NC_000004.12:g.39500223T>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg470Ile	missense variant	-	NC_000004.12:g.39500219C>A	NCI-TCGA
NCI-TCGA novel	p.Ile471Leu	missense variant	-	NC_000004.12:g.39500217T>G	NCI-TCGA
rs757002418	p.Pro472Ala	missense variant	-	NC_000004.12:g.39500214G>C	ExAC,gnomAD
rs1337082775	p.Tyr473His	missense variant	-	NC_000004.12:g.39500211A>G	TOPMed
rs146932231	p.Pro475Ser	missense variant	-	NC_000004.12:g.39500205G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs763664159	p.Ser476Phe	missense variant	-	NC_000004.12:g.39500201G>A	ExAC,gnomAD
rs760852204	p.Gly477Ser	missense variant	-	NC_000004.12:g.39500199C>T	ExAC,gnomAD
rs1279344897	p.Ile479Phe	missense variant	-	NC_000004.12:g.39500193T>A	gnomAD
rs775554067	p.Pro480Ser	missense variant	-	NC_000004.12:g.39500190G>A	ExAC,TOPMed,gnomAD
rs764992651	p.Pro480Leu	missense variant	-	NC_000004.12:g.39500189G>A	ExAC,TOPMed,gnomAD
rs775554067	p.Pro480Thr	missense variant	-	NC_000004.12:g.39500190G>T	ExAC,TOPMed,gnomAD
rs1239210469	p.Phe482Val	missense variant	-	NC_000004.12:g.39500184A>C	gnomAD
rs1373738864	p.Phe482Tyr	missense variant	-	NC_000004.12:g.39500183A>T	gnomAD
rs1373738864	p.Phe482Cys	missense variant	-	NC_000004.12:g.39500183A>C	gnomAD
rs1280951409	p.Ser483Asn	missense variant	-	NC_000004.12:g.39500180C>T	gnomAD
COSM119730	p.Leu484Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000004.12:g.39500178G>A	NCI-TCGA Cosmic
rs1339369402	p.Pro487Thr	missense variant	-	NC_000004.12:g.39500169G>T	gnomAD
rs772229766	p.Pro488Ser	missense variant	-	NC_000004.12:g.39500166G>A	ExAC,gnomAD
rs762039752	p.Asn489Lys	missense variant	-	NC_000004.12:g.39500161G>T	ExAC,TOPMed,gnomAD
rs1359236936	p.Lys491Arg	missense variant	-	NC_000004.12:g.39500156T>C	gnomAD
rs1158537408	p.Pro492Thr	missense variant	-	NC_000004.12:g.39500154G>T	gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0002875	Cooley's anemia	disease	BEFREE
C0005283	beta Thalassemia	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0010709	Cyst	phenotype	BEFREE
C0017536	Giardiasis	disease	BEFREE
C0018213	Graves Disease	disease	BEFREE
C0020459	Hyperinsulinism	disease	BEFREE
C0020615	Hypoglycemia	disease	BEFREE
C0021294	Infant, Premature	phenotype	BEFREE
C0023903	Liver neoplasms	group	CTD_human
C0029182	orbit (eye disorders)	group	BEFREE
C0345904	Malignant neoplasm of liver	disease	CTD_human
C0687720	Central Diabetes Insipidus	disease	BEFREE
C1411966	Clostridium; difficile (disorder)	disease	BEFREE
C1704436	Peripheral Arterial Diseases	group	GWASCAT
C1864903	Hyperinsulinemic hypoglycemia	disease	BEFREE
C3841475	beta^+^ Thalassemia	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003979	UDP-glucose 6-dehydrogenase activity	IDA
GO:0051287	NAD binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001702	gastrulation with mouth forming second	ISS
GO:0005975	carbohydrate metabolic process	IEA
GO:0006024	glycosaminoglycan biosynthetic process	IBA
GO:0006065	UDP-glucuronate biosynthetic process	IEA
GO:0006065	UDP-glucuronate biosynthetic process	IDA
GO:0006065	UDP-glucuronate biosynthetic process	TAS
GO:0015012	heparan sulfate proteoglycan biosynthetic process	ISS
GO:0030206	chondroitin sulfate biosynthetic process	ISS
GO:0034214	protein hexamerization	IDA
GO:0055114	oxidation-reduction process	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	IDA
GO:0005829	cytosol	IBA
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	HDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156588	Glucuronidation	TAS
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	TAS
R-HSA-211859	Biological oxidations	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of UGDH mRNA	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of UGDH mRNA]	27071940
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in increased expression of UGDH mRNA	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UGDH mRNA	22698814
C034086	1,5-naphthalenediamine	1,5-naphthalenediamine affects the expression of UGDH mRNA	17114358
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of UGDH mRNA	24810058
C014211	2,3,7,8-tetrachlorodibenzofuran	2,3,7,8-tetrachlorodibenzofuran affects the expression of UGDH mRNA	18343893; 20702594;
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of UGDH protein	23457121
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of UGDH mRNA	20005886; 21851831;
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of UGDH mRNA	21346803
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in decreased expression of UGDH mRNA	20406850
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of UGDH mRNA	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of UGDH protein	23457121
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of UGDH mRNA	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UGDH mRNA	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of UGDH mRNA	19561079
C035207	4-amino-2,6-dinitrotoluene	4-amino-2,6-dinitrotoluene affects the expression of UGDH mRNA	21346803
C496492	abrine	abrine results in decreased expression of UGDH mRNA	31054353
D000082	Acetaminophen	Acetaminophen results in decreased expression of UGDH mRNA	21420995; 29067470;
D000082	Acetaminophen	Acetaminophen affects the expression of UGDH mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of UGDH mRNA	30723492
D000111	Acetylcysteine	Acetylcysteine results in increased expression of UGDH mRNA	16084531
D000452	Aldrin	Aldrin results in increased expression of UGDH mRNA	18579281
D000077556	Alitretinoin	[pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA	16292757
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of UGDH protein	26597043
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UGDH mRNA	16483693
D001151	Arsenic	[APOE protein affects the susceptibility to Arsenic] which affects the expression of UGDH mRNA	22719926
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of UGDH protein	25258189
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of UGDH mRNA	20458559
C547126	AZM551248	AZM551248 results in increased expression of UGDH mRNA	22323515
D001397	Azoxymethane	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of UGDH mRNA	29950665
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of UGDH mRNA	21714911
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in increased expression of UGDH protein modified form	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of UGDH mRNA	19770486; 21715664;
C105430	benzofuran	benzofuran affects the expression of UGDH mRNA	17114358
C044887	beta-methylcholine	beta-methylcholine affects the expression of UGDH mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of UGDH mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of UGDH mRNA	21269433
C006780	bisphenol A	bisphenol A results in increased expression of UGDH mRNA	28780062; 30248606;
C006780	bisphenol A	bisphenol A affects the expression of UGDH mRNA	30903817
C006780	bisphenol A	bisphenol A results in increased expression of UGDH mRNA	25181051
C032036	bromobenzene	bromobenzene metabolite binds to UGDH protein	17305373
C018475	butyraldehyde	butyraldehyde results in decreased expression of UGDH mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of UGDH mRNA	24067728
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of UGDH mRNA	18654764
D002220	Carbamazepine	Carbamazepine results in decreased expression of UGDH mRNA	17381134
D002220	Carbamazepine	Carbamazepine results in increased expression of UGDH mRNA	17381134
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of UGDH mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of UGDH mRNA	31150632
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of UGDH mRNA]	31150632
C418118	CI 1044	CI 1044 results in increased expression of UGDH mRNA	17569694
D002945	Cisplatin	Cisplatin results in increased expression of UGDH mRNA	19561079
D002945	Cisplatin	Cisplatin results in increased expression of UGDH protein	16803524
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of UGDH mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of UGDH mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of UGDH mRNA	22941251
C018021	cobaltous chloride	cobaltous chloride results in increased expression of UGDH mRNA	24386269
C018021	cobaltous chloride	cobaltous chloride results in increased expression of UGDH protein	24386269
D003300	Copper	UGDH protein binds to Copper	15359738
C030123	coumarin	coumarin results in increased expression of UGDH mRNA	18480146
D003375	Coumestrol	Coumestrol results in decreased expression of UGDH mRNA	19167446
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of UGDH mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in decreased expression of UGDH mRNA	20106945
D016264	Dextran Sulfate	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of UGDH mRNA	29950665
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of UGDH mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of UGDH mRNA	28962523
D004041	Dietary Fats	Dietary Fats affects the expression of UGDH mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of UGDH mRNA	15238619; 18042831;
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of UGDH mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of UGDH mRNA]	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of UGDH mRNA	30102407
D004052	Diethylnitrosamine	[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of UGDH protein	23457121
D004052	Diethylnitrosamine	[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of UGDH protein	23457121
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of UGDH mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of UGDH mRNA	19638242
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of UGDH mRNA	29581250
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of UGDH mRNA	27638505
D004147	Dioxins	Dioxins affects the expression of UGDH mRNA	20463971
D004237	Diuron	Diuron results in increased expression of UGDH mRNA	21551480
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UGDH mRNA	27188386
D004726	Endosulfan	Endosulfan results in increased expression of UGDH mRNA	29391264
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of UGDH mRNA	16084531
C472787	erucylphospho-N,N,N-trimethylpropylammonium	erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of UGDH mRNA	29464035
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UGDH mRNA	19619570
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of UGDH mRNA	30165855
D004958	Estradiol	Estradiol results in increased expression of UGDH mRNA	19619570; 21185374;
D000431	Ethanol	Ethanol affects the expression of UGDH mRNA	30319688
D000431	Ethanol	Ethanol affects the splicing of UGDH mRNA	30319688
D000431	Ethanol	Ethanol results in decreased expression of UGDH mRNA	17920746
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of UGDH mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of UGDH mRNA	23129252
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of UGDH gene	15755804
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of UGDH protein	24090815
D005054	Eugenol	Eugenol results in increased expression of UGDH mRNA	16292757
D000078328	Felbamate	Felbamate results in decreased expression of UGDH mRNA	17381134
D000078328	Felbamate	Felbamate results in increased expression of UGDH mRNA	17381134
D018120	Finasteride	Finasteride results in increased expression of UGDH mRNA	24136188
D005472	Fluorouracil	UGDH protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in increased expression of UGDH mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in increased expression of UGDH mRNA	16221962
C039281	furan	furan results in increased expression of UGDH mRNA	24183702
C039281	furan	furan results in increased expression of UGDH mRNA	26194646
D000077206	Gabapentin	Gabapentin results in decreased expression of UGDH mRNA	17381134
C106014	gedunin	gedunin results in increased expression of UGDH mRNA	17010675
D019833	Genistein	ESR2 promotes the reaction [Genistein results in decreased expression of UGDH protein]	20884965
D019833	Genistein	Genistein results in decreased expression of UGDH protein	20884965
D019833	Genistein	Genistein results in increased expression of UGDH mRNA	15378649; 16865672;
D005839	Gentamicins	Gentamicins results in increased expression of UGDH mRNA	22061828
D006118	Griseofulvin	Griseofulvin affects the expression of UGDH mRNA	12735108
D007529	Isoflavones	Isoflavones results in increased expression of UGDH mRNA	17374662
D007545	Isoproterenol	Isoproterenol results in increased expression of UGDH mRNA	21335049
D007649	Ketamine	Ketamine results in decreased expression of UGDH mRNA	20080153
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of UGDH mRNA	18654764
D000077339	Leflunomide	Leflunomide results in increased expression of UGDH mRNA	24136188
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of UGDH mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of UGDH mRNA	16507785
C002950	methylformamide	methylformamide affects the expression of UGDH mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of UGDH mRNA	17040096
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of UGDH mRNA	28496038
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of UGDH protein	28496038
C008493	methylselenic acid	methylselenic acid affects the expression of UGDH mRNA	14617803
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of UGDH mRNA	29244179
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of UGDH mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of UGDH mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of UGDH mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of UGDH mRNA	25554681
C051752	nefazodone	nefazodone results in increased expression of UGDH mRNA	24136188
C012655	nimesulide	nimesulide results in increased expression of UGDH mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of UGDH mRNA	17616710
C014129	N-nitrosodiethanolamine	N-nitrosodiethanolamine results in decreased expression of UGDH mRNA	30102407
C570897	NSC668394	NSC668394 results in increased expression of UGDH mRNA	27137931
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of UGDH mRNA	25729387
D000073878	Palm Oil	Palm Oil affects the expression of UGDH mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of UGDH mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in increased expression of UGDH protein	17922515
D052638	Particulate Matter	Particulate Matter results in increased methylation of UGDH gene	28495853
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of UGDH mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of UGDH protein	22609092
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of UGDH protein	26879310
D026023	Permethrin	Permethrin results in increased expression of UGDH mRNA	30629241
D010629	Phenformin	Phenformin results in decreased expression of UGDH protein	4270849
D010634	Phenobarbital	Phenobarbital results in increased expression of UGDH protein	19952500
D010634	Phenobarbital	Phenobarbital affects the expression of UGDH mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of UGDH mRNA	28541575
D010634	Phenobarbital	Phenobarbital results in increased expression of UGDH protein	28541575
D010634	Phenobarbital	Phenobarbital results in increased expression of UGDH mRNA	17381134; 19162173;
D010634	Phenobarbital	Phenobarbital results in increased expression of UGDH protein	24090815
D010672	Phenytoin	Phenytoin results in decreased expression of UGDH mRNA	17381134
C008922	piperine	piperine results in decreased expression of UGDH mRNA	16292757
C006253	pirinixic acid	[pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA	16292757
C006253	pirinixic acid	pirinixic acid results in decreased expression of UGDH mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of UGDH mRNA	15375163; 16221962; 20813756; 23811191;
D010938	Plant Oils	Plant Oils results in increased expression of UGDH mRNA	23370395
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of UGDH mRNA	19162173
C045950	propiconazole	propiconazole results in increased expression of UGDH mRNA	21278054
D011748	Pyrogallol	Pyrogallol results in increased expression of UGDH mRNA	20362636
D011794	Quercetin	Quercetin results in decreased expression of UGDH protein	18095365
D012293	Rifampin	[Rifampin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA	16292757
D012293	Rifampin	Rifampin results in increased expression of UGDH mRNA	16292757
D012402	Rotenone	Rotenone results in increased expression of UGDH mRNA	28374803
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of UGDH mRNA]	31150632
D012715	Sesame Oil	Sesame Oil results in decreased expression of UGDH mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of UGDH protein	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of UGDH mRNA	16882884
C017947	sodium arsenite	sodium arsenite results in increased expression of UGDH mRNA	29361514
C017947	sodium arsenite	sodium arsenite affects the expression of UGDH mRNA	29319823
C017947	sodium arsenite	sodium arsenite results in decreased expression of UGDH mRNA	28595984
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in increased expression of UGDH protein modified form	24464499
D053260	Soot	Soot results in increased expression of UGDH mRNA	22461453
C013698	tallow	tallow affects the expression of UGDH mRNA	19680557
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UGDH mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of UGDH mRNA	19619570
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGDH mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of UGDH mRNA	18343893; 20702594; 26377647;
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of UGDH mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGDH mRNA	15328365; 15800033; 16611356; 16960034; 17949056; 18796159; 19474220; 19770486; 20005886; 21851831; 21889950; 23864506; 25975270; 26290441; 27562557; 31511937;
D013749	Tetrachlorodibenzodioxin	[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of UGDH mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UGDH mRNA	16960034; 20558275;
D013827	Thiabendazole	Thiabendazole results in increased expression of UGDH mRNA	18539377
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of UGDH mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of UGDH mRNA	23411599
C009495	titanium dioxide	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of UGDH mRNA	29950665
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of UGDH protein	30291989
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of UGDH mRNA	28065790
D014044	Tolbutamide	Tolbutamide results in decreased expression of UGDH protein	4270849
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of UGDH mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of UGDH mRNA	25729387
C012589	trichostatin A	trichostatin A results in increased expression of UGDH mRNA	15901671
C050414	tripterine	tripterine results in increased expression of UGDH mRNA	17010675
D000077288	Troglitazone	Troglitazone results in increased expression of UGDH mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in increased expression of UGDH mRNA	22378314; 29453283;
C406224	valdecoxib	valdecoxib results in increased expression of UGDH mRNA	24136188
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UGDH mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of UGDH mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of UGDH mRNA	23179753; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of UGDH gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of UGDH mRNA	17381134
D014635	Valproic Acid	Valproic Acid results in increased expression of UGDH mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of UGDH protein	17922515
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of UGDH gene	28495853

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0021	Allosteric enzyme
KW-0025	Alternative splicing
KW-0119	Carbohydrate metabolism
KW-0520	NAD
KW-0560	Oxidoreductase
KW-0597	Phosphoprotein
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR008927	6-PGluconate_DH-like_C_sf
IPR036291	NAD(P)-bd_dom_sf
IPR017476	UDP-Glc/GDP-Man
IPR014027	UDP-Glc/GDP-Man_DH_C
IPR036220	UDP-Glc/GDP-Man_DH_C_sf
IPR014026	UDP-Glc/GDP-Man_DH_dimer
IPR001732	UDP-Glc/GDP-Man_DH_N
IPR028356	UDPglc_DH_euk

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF00984	UDPG_MGDP_dh
PF03720	UDPG_MGDP_dh_C
PF03721	UDPG_MGDP_dh_N

Gene: UGDH

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction