| Tag | Content |
|---|---|
| Uniprot ID | O60928; A0PGH1; O76023; Q53SA1; Q8N3Y4; |
| Entrez ID | 3769 |
| Genbank protein ID | AAX08099.1; CAA07552.1; BAG36730.1; AAC15769.1; EAW71019.1; AAD08673.1; AAX08098.1; BAA28271.1; AAH37290.1; BAA28273.1; AAX93190.1; CAA06878.1; |
| Genbank nucleotide ID | NM_002242.4; NM_001172416.1; NM_001172417.1; |
| Ensembl protein ID | ENSP00000386251; ENSP00000386408; ENSP00000233826; |
| Ensembl nucleotide ID | ENSG00000115474 |
| Gene name | Inward rectifier potassium channel 13 |
| Gene symbol | KCNJ13 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Sequence | MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD MRWRWMMLVF 60 SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV KYITSFTAAF SFSLETQLTI 120 GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDTAVVAH 180 MDGKPNLIFQ VANTRPSPLT SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP 240 LTYYHSITPS SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA 300 SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN FQISETGLTE 360 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.