| Tag | Content |
|---|---|
| Uniprot ID | O88393; Q6NS72; |
| Entrez ID | 21814 |
| Genbank protein ID | AAC28564.1; AAH70428.1; |
| Genbank nucleotide ID | NM_011578.4 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Transforming growth factor beta receptor type 3 |
| Gene symbol | Tgfbr3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25382630 |
| Functional description | Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity). |
| Sequence | MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV LSGCASRGTT 60 GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK PVVFLLNSPQ PLVWHVKTER 120 LAAGVPRLFL VSEGSVVQFS SGNFSLTAET EERSFPQENE HLLHWAQKEY GAVTSFTELK 180 IARNIYIKVG EDQVFPPTCN IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI 240 SPNSNPYSTF QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD 300 SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA NRFHLRLENN 360 EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG FPFPFPDIPR RGWKEGEDRI 420 PRPKEPIIPR VQLLPDHREP EEVQGGVNIA LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT 480 LLDPSCKAKM NGTHFVLESP LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE 540 DLESGDNGFP GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD 600 LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS DYTIIENICP 660 KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL FLHCELTLCS RNKGSQKLPK 720 CVTPDDACTS LDATMIWTMM QNKKTFTKPL AVVLQVDYKE NVPNMKESSP VPPPPQIFHG 780 LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ 840 STPCSSSSTA |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005024 | transforming growth factor beta-activated receptor activity | ISO |
| GO:0005024 | transforming growth factor beta-activated receptor activity | IMP |
| GO:0005024 | transforming growth factor beta-activated receptor activity | IDA |
| GO:0005114 | type II transforming growth factor beta receptor binding | ISO |
| GO:0005160 | transforming growth factor beta receptor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005539 | glycosaminoglycan binding | IDA |
| GO:0008201 | heparin binding | ISO |
| GO:0015026 | coreceptor activity | ISO |
| GO:0017134 | fibroblast growth factor binding | ISO |
| GO:0030165 | PDZ domain binding | IPI |
| GO:0046332 | SMAD binding | ISO |
| GO:0046332 | SMAD binding | IMP |
| GO:0048185 | activin binding | ISO |
| GO:0050431 | transforming growth factor beta binding | ISO |
| GO:0050431 | transforming growth factor beta binding | IDA |
| GO:0070123 | transforming growth factor beta receptor activity, type III | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001568 | blood vessel development | IMP |
| GO:0001570 | vasculogenesis | IMP |
| GO:0001649 | osteoblast differentiation | IMP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001824 | blastocyst development | IDA |
| GO:0001837 | epithelial to mesenchymal transition | ISO |
| GO:0001889 | liver development | IMP |
| GO:0001974 | blood vessel remodeling | IMP |
| GO:0003150 | muscular septum morphogenesis | IMP |
| GO:0003151 | outflow tract morphogenesis | IMP |
| GO:0003223 | ventricular compact myocardium morphogenesis | IMP |
| GO:0003347 | epicardial cell to mesenchymal cell transition | TAS |
| GO:0006955 | immune response | ISO |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | ISO |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IGI |
| GO:0007181 | transforming growth factor beta receptor complex assembly | ISO |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0010629 | negative regulation of gene expression | IDA |
| GO:0010633 | negative regulation of epithelial cell migration | IMP |
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | IMP |
| GO:0030509 | BMP signaling pathway | ISO |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | IMP |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030513 | positive regulation of BMP signaling pathway | IMP |
| GO:0032354 | response to follicle-stimulating hormone | ISO |
| GO:0032963 | collagen metabolic process | IGI |
| GO:0034695 | response to prostaglandin E | ISO |
| GO:0034699 | response to luteinizing hormone | ISO |
| GO:0035556 | intracellular signal transduction | ISO |
| GO:0043393 | regulation of protein binding | ISO |
| GO:0050680 | negative regulation of epithelial cell proliferation | IMP |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IMP |
| GO:0051271 | negative regulation of cellular component movement | ISO |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis | IMP |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060038 | cardiac muscle cell proliferation | IMP |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | IMP |
| GO:0060216 | definitive hemopoiesis | IMP |
| GO:0060317 | cardiac epithelial to mesenchymal transition | ISO |
| GO:0060318 | definitive erythrocyte differentiation | IMP |
| GO:0060347 | heart trabecula formation | IMP |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation | IMP |
| GO:0060412 | ventricular septum morphogenesis | IMP |
| GO:0060939 | epicardium-derived cardiac fibroblast cell development | IMP |
| GO:0060976 | coronary vasculature development | TAS |
| GO:0060977 | coronary vasculature morphogenesis | TAS |
| GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis | IMP |
| GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis | TAS |
| GO:0061032 | visceral serous pericardium development | TAS |
| GO:0061384 | heart trabecula morphogenesis | IMP |
| GO:0062009 | secondary palate development | IMP |
| GO:0065003 | protein-containing complex assembly | ISO |
| GO:0097746 | regulation of blood vessel diameter | TAS |
| GO:1902338 | negative regulation of apoptotic process involved in morphogenesis | IMP |
| GO:0046328 | regulation of JNK cascade | IMP |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | TAS |
| GO:0009897 | external side of plasma membrane | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0016021 | integral component of membrane | ISO |
| GO:0031012 | extracellular matrix | ISO |
| GO:0034673 | inhibin-betaglycan-ActRII complex | ISO |
| GO:0043235 | receptor complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00100 | Zona_pellucida |