Gene: Dhrs3

Basic information

Tag Content
Uniprot ID O88876; Q3UAD1; Q91WR0; Q91XC3; Q922A6;
Entrez ID 20148
Genbank protein ID BAE30384.1; AAC63265.1; AAH10972.1; AAH13540.1; AAD55403.1; BAC28098.1; AAH08980.1; CAA64602.1;
Genbank nucleotide ID NM_011303.6
Ensembl protein ID ENSMUSP00000101370; ENSMUSP00000122552;
Ensembl nucleotide ID ENSMUSG00000066026
Gene name Short-chain dehydrogenase/reductase 3
Gene symbol Dhrs3
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 24733397
Functional description Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Sequence
MVWKWLGALV VFPLQMIYLV TKAAVGMVLP PKLRDLSRES VLITGGGRGI GRHLAREFAE 60
RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR EEVYQMAKAV REKVGDITIL 120
VNNAAVVHGK SLMDSDDDAL LKSQHVNTLG QFWTTKAFLP RMLELQNGHI VCLNSVLALS 180
AIPGAIDYCT SKASAFAFME SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP 240
LKPETVARRT VDAVQQNQAL LLLPWTMNIL IILKSILPQA ALEEIHRFSG TYTCMNTFKG 300
RT 302

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004745 retinol dehydrogenase activityIBA
GO:0004745 retinol dehydrogenase activityIMP
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorIBA
GO:0052650 NADP-retinol dehydrogenase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001523 retinoid metabolic processIBA
GO:0001523 retinoid metabolic processIMP
GO:0003151 outflow tract morphogenesisIMP
GO:0030278 regulation of ossificationIMP
GO:0042572 retinol metabolic processIEA
GO:0048385 regulation of retinoic acid receptor signaling pathwayIBA
GO:0048387 negative regulation of retinoic acid receptor signaling pathwayIMP
GO:0055114 oxidation-reduction processIEA
GO:0060021 roof of mouth developmentIMP
GO:0060349 bone morphogenesisIMP
GO:0060411 cardiac septum morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005811 lipid dropletIBA
GO:0016021 integral component of membraneIEA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-2187335 The retinoid cycle in cones (daylight vision)IEA
R-MMU-2187338 Visual phototransductionIEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-418594 G alpha (i) signalling eventsIEA
R-MMU-5362517 Signaling by Retinoic AcidIEA
R-MMU-5365859 RA biosynthesis pathwayIEA
R-MMU-9006931 Signaling by Nuclear ReceptorsIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0472 Membrane
KW-0521 NADP
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00106 adh_short

Protein-miRNA interaction