| Tag | Content |
|---|---|
| Uniprot ID | O88895; O88896; |
| Entrez ID | |
| Genbank protein ID | AAC67258.1; AAC36306.1; AAC36305.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Histone deacetylase 3 |
| Gene symbol | Hdac3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23506836 |
| Functional description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (PubMed:26776516). During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (PubMed:26776516). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). |
| Sequence | MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 60 FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 120 KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 180 FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 240 SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300 RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 360 TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 420 DKES 424 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IDA |
| GO:0003682 | chromatin binding | ISO |
| GO:0003682 | chromatin binding | IDA |
| GO:0003714 | transcription corepressor activity | ISS |
| GO:0003714 | transcription corepressor activity | ISO |
| GO:0004407 | histone deacetylase activity | ISO |
| GO:0004407 | histone deacetylase activity | TAS |
| GO:0004407 | histone deacetylase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | ISO |
| GO:0008134 | transcription factor binding | TAS |
| GO:0008134 | transcription factor binding | IDA |
| GO:0019213 | deacetylase activity | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0030332 | cyclin binding | ISO |
| GO:0031490 | chromatin DNA binding | IDA |
| GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | IEA |
| GO:0033558 | protein deacetylase activity | ISO |
| GO:0033558 | protein deacetylase activity | IDA |
| GO:0042826 | histone deacetylase binding | ISO |
| GO:0051020 | GTPase binding | ISO |
| GO:0051059 | NF-kappaB binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0001934 | positive regulation of protein phosphorylation | ISS |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0006325 | chromatin organization | TAS |
| GO:0006476 | protein deacetylation | ISO |
| GO:0007346 | regulation of mitotic cell cycle | IDA |
| GO:0016575 | histone deacetylation | IMP |
| GO:0016575 | histone deacetylation | IGI |
| GO:0031398 | positive regulation of protein ubiquitination | IMP |
| GO:0031647 | regulation of protein stability | ISS |
| GO:0031647 | regulation of protein stability | ISO |
| GO:0032008 | positive regulation of TOR signaling | ISS |
| GO:0032008 | positive regulation of TOR signaling | ISO |
| GO:0032692 | negative regulation of interleukin-1 production | ISO |
| GO:0032720 | negative regulation of tumor necrosis factor production | ISO |
| GO:0032922 | circadian regulation of gene expression | IGI |
| GO:0032922 | circadian regulation of gene expression | IMP |
| GO:0040014 | regulation of multicellular organism growth | IGI |
| GO:0042307 | positive regulation of protein import into nucleus | ISS |
| GO:0042307 | positive regulation of protein import into nucleus | ISO |
| GO:0042752 | regulation of circadian rhythm | IMP |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | IDA |
| GO:0043525 | positive regulation of neuron apoptotic process | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISS |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0046329 | negative regulation of JNK cascade | ISO |
| GO:0046826 | negative regulation of protein export from nucleus | ISO |
| GO:0051225 | spindle assembly | ISO |
| GO:0070932 | histone H3 deacetylation | IBA |
| GO:0070933 | histone H4 deacetylation | IBA |
| GO:0070933 | histone H4 deacetylation | IDA |
| GO:0071498 | cellular response to fluid shear stress | ISS |
| GO:0071498 | cellular response to fluid shear stress | ISO |
| GO:0120162 | positive regulation of cold-induced thermogenesis | IMP |
| GO:1990679 | histone H4-K12 deacetylation | IDA |
| GO:2000676 | positive regulation of type B pancreatic cell apoptotic process | ISO |
| GO:2000726 | negative regulation of cardiac muscle cell differentiation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000118 | histone deacetylase complex | ISO |
| GO:0000118 | histone deacetylase complex | TAS |
| GO:0000118 | histone deacetylase complex | IBA |
| GO:0000785 | chromatin | ISO |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | TAS |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | TAS |
| GO:0005737 | cytoplasm | IDA |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0017053 | transcriptional repressor complex | ISS |
| GO:0017053 | transcriptional repressor complex | ISO |
| GO:0072686 | mitotic spindle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00850 | Hist_deacetyl |