CleftGeneDB-Search

Gene: TGDS

Basic information

Tag	Content
Uniprot ID	O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9;
Entrez ID	23483
Genbank protein ID	EAX08941.1; AAD50061.1; AAH33675.1; CAA06840.1; BAG36061.1; EAX08940.1; AAH05284.1; AAT11156.1;
Genbank nucleotide ID	NM_014305.3; NM_001304430.1;
Ensembl protein ID	ENSP00000261296
Ensembl nucleotide ID	ENSG00000088451
Gene name	dTDP-D-glucose 4,6-dehydratase
Gene symbol	TGDS
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD KLDYCASLKN 60 LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA QTHVDLSFVR AFEFTYVNVY 120 GTHVLVSAAH EARVEKFIYV STDEVYGGSL DKEFDESSPK QPTNPYASSK AAAECFVQSY 180 WEQYKFPVVI TRSSNVYGPH QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE 240 AFLTVLKKGK PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM 300 RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	TGDS	534594	A6QLW2		Bos taurus	Prediction	More>>
1:1 ortholog	TGDS	485521	E2QWQ8		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	TGDS	102170331	A0A452FWY8		Capra hircus	Prediction	More>>
1:1 ortholog	TGDS	23483	O95455		Homo sapiens	Prediction	More>>
1:1 ortholog	Tgds	76355	Q8VDR7	CPO	Mus musculus	Publication	More>>
1:1 ortholog	TGDS	467299	H2Q7P8		Pan troglodytes	Prediction	More>>
1:1 ortholog	TGDS		F1RP60		Sus scrofa	Prediction	More>>
1:1 ortholog	TGDS	100354182	G1SYY5		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Tgds		A0A0G2JZS4		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1269740294	p.Ser2Leu	missense variant	-	NC_000013.11:g.94596132G>A	gnomAD
rs1434083022	p.Ser2Ala	missense variant	-	NC_000013.11:g.94596133A>C	gnomAD
rs374701618	p.Ala3Val	missense variant	-	NC_000013.11:g.94596129G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs755749986	p.Ala4Val	missense variant	-	NC_000013.11:g.94596126G>A	ExAC,gnomAD
rs765805073	p.Ala4Thr	missense variant	-	NC_000013.11:g.94596127C>T	ExAC,gnomAD
NCI-TCGA novel	p.Cys5Trp	missense variant	-	NC_000013.11:g.94596122A>C	NCI-TCGA
rs1261136477	p.Cys5Gly	missense variant	-	NC_000013.11:g.94596124A>C	gnomAD
rs766990686	p.Glu7Asp	missense variant	-	NC_000013.11:g.94596116C>A	ExAC,gnomAD
rs1443502871	p.Glu7Lys	missense variant	-	NC_000013.11:g.94596118C>T	TOPMed
rs200877310	p.Glu8Asp	missense variant	-	NC_000013.11:g.94596113T>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1181173239	p.Glu8Gln	missense variant	-	NC_000013.11:g.94596115C>G	TOPMed
rs202097673	p.Pro9Ser	missense variant	-	NC_000013.11:g.94596112G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs202097673	p.Pro9Ala	missense variant	-	NC_000013.11:g.94596112G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs762709267	p.Pro9Arg	missense variant	-	NC_000013.11:g.94596111G>C	ExAC,gnomAD
rs745748712	p.Trp10Cys	missense variant	-	NC_000013.11:g.94596107C>G	ExAC,gnomAD
rs370526233	p.Trp10Arg	missense variant	-	NC_000013.11:g.94596109A>G	ESP,ExAC,TOPMed,gnomAD
rs370526233	p.Trp10Gly	missense variant	-	NC_000013.11:g.94596109A>C	ESP,ExAC,TOPMed,gnomAD
rs151012980	p.Leu12Phe	missense variant	-	NC_000013.11:g.94596103G>A	ESP,ExAC,TOPMed,gnomAD
rs771002382	p.Pro13Ser	missense variant	-	NC_000013.11:g.94596100G>A	ExAC,TOPMed,gnomAD
rs1247681682	p.Pro13Leu	missense variant	-	NC_000013.11:g.94596099G>A	gnomAD
rs937003782	p.Gly14Arg	missense variant	-	NC_000013.11:g.94596097C>G	TOPMed,gnomAD
rs34991132	p.Gly15Arg	missense variant	-	NC_000013.11:g.94596094C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs34991132	p.Gly15Ser	missense variant	-	NC_000013.11:g.94596094C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs34991132	p.Gly15Ser	missense variant	-	NC_000013.11:g.94596094C>T	UniProt,dbSNP
VAR_049122	p.Gly15Ser	missense variant	-	NC_000013.11:g.94596094C>T	UniProt
rs758873634	p.Phe16Ile	missense variant	-	NC_000013.11:g.94596091A>T	ExAC,gnomAD
rs1157277857	p.Ala17Val	missense variant	-	NC_000013.11:g.94596087G>A	gnomAD
rs748516684	p.Lys18Arg	missense variant	-	NC_000013.11:g.94596084T>C	ExAC,gnomAD
rs1306116133	p.Thr23Ser	missense variant	-	NC_000013.11:g.94596069G>C	TOPMed
rs1180626621	p.Gly24Ser	missense variant	-	NC_000013.11:g.94596067C>T	gnomAD
rs779619758	p.Ala26Thr	missense variant	-	NC_000013.11:g.94596061C>T	ExAC,gnomAD
rs779619758	p.Ala26Ser	missense variant	-	NC_000013.11:g.94596061C>A	ExAC,gnomAD
NCI-TCGA novel	p.Gly27Asp	missense variant	-	NC_000013.11:g.94596057C>T	NCI-TCGA
rs1241216031	p.Phe28Leu	missense variant	-	NC_000013.11:g.94596053G>T	gnomAD
rs751069260	p.Ala30Val	missense variant	-	NC_000013.11:g.94593905G>A	ExAC,gnomAD
rs1263619932	p.Ser31Leu	missense variant	-	NC_000013.11:g.94593902G>A	gnomAD
rs765037542	p.His32Arg	missense variant	-	NC_000013.11:g.94593899T>C	ExAC,gnomAD
rs752306743	p.His32Tyr	missense variant	-	NC_000013.11:g.94593900G>A	ExAC,gnomAD
rs144478268	p.Met33Val	missense variant	-	NC_000013.11:g.94593897T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1039955963	p.Met33Thr	missense variant	-	NC_000013.11:g.94593896A>G	gnomAD
rs1250187037	p.Val35Ile	missense variant	-	NC_000013.11:g.94593891C>T	gnomAD
rs766334560	p.Glu39Gly	missense variant	-	NC_000013.11:g.94593878T>C	ExAC,gnomAD
rs1280468078	p.Asp40Gly	missense variant	-	NC_000013.11:g.94593875T>C	gnomAD
rs773350207	p.Ile46Val	missense variant	-	NC_000013.11:g.94593858T>C	ExAC,gnomAD
rs773350207	p.Ile46Leu	missense variant	-	NC_000013.11:g.94593858T>G	ExAC,gnomAD
rs1411467881	p.Ile47Val	missense variant	-	NC_000013.11:g.94593855T>C	TOPMed
NCI-TCGA novel	p.Leu49Val	missense variant	-	NC_000013.11:g.94593849G>C	NCI-TCGA
NCI-TCGA novel	p.Asp50Tyr	missense variant	-	NC_000013.11:g.94593846C>A	NCI-TCGA
rs1231614540	p.Tyr54Cys	missense variant	-	NC_000013.11:g.94592302T>C	TOPMed
rs761955397	p.Cys55Ser	missense variant	-	NC_000013.11:g.94592299C>G	ExAC,gnomAD
COSM4048787	p.Ala56Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94592296G>A	NCI-TCGA Cosmic
rs764401457	p.Asn60Lys	missense variant	-	NC_000013.11:g.94592283A>T	ExAC,gnomAD
rs1378049960	p.Asn60Thr	missense variant	-	NC_000013.11:g.94592284T>G	TOPMed,gnomAD
RCV000624236	p.Asn60Lys	missense variant	Inborn genetic diseases	NC_000013.11:g.94592283A>T	ClinVar
rs763028354	p.Ile64Thr	missense variant	-	NC_000013.11:g.94592272A>G	ExAC,gnomAD
rs775927957	p.Ser65Phe	missense variant	-	NC_000013.11:g.94592269G>A	ExAC,TOPMed,gnomAD
rs770016149	p.Gln68Arg	missense variant	-	NC_000013.11:g.94592260T>C	ExAC,TOPMed,gnomAD
rs1221199075	p.Lys71Arg	missense variant	-	NC_000013.11:g.94592251T>C	gnomAD
COSM948927	p.Lys71Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94592251T>G	NCI-TCGA Cosmic
COSM948926	p.Phe72Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94592248A>C	NCI-TCGA Cosmic
rs1267795918	p.Ile73Val	missense variant	-	NC_000013.11:g.94592246T>C	gnomAD
rs746410117	p.Gln74His	missense variant	-	NC_000013.11:g.94592241C>A	ExAC,gnomAD
rs1220935898	p.Ile77Met	missense variant	-	NC_000013.11:g.94590935T>C	gnomAD
rs573212730	p.Ile77Val	missense variant	-	NC_000013.11:g.94590937T>C	1000Genomes,ExAC,gnomAD
rs146404830	p.Ile77Thr	missense variant	-	NC_000013.11:g.94590936A>G	1000Genomes,ExAC,gnomAD
rs1322347232	p.Cys78Arg	missense variant	-	NC_000013.11:g.94590934A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Ser80Cys	missense variant	-	NC_000013.11:g.94590927G>C	NCI-TCGA
rs1290576275	p.Phe82Tyr	missense variant	-	NC_000013.11:g.94590921A>T	gnomAD
NCI-TCGA novel	p.Val83Gly	missense variant	-	NC_000013.11:g.94590918A>C	NCI-TCGA
rs373246659	p.Val83Ala	missense variant	-	NC_000013.11:g.94590918A>G	ESP,ExAC,TOPMed,gnomAD
rs1229206078	p.Glu88Lys	missense variant	-	NC_000013.11:g.94590904C>T	TOPMed
rs751503526	p.Thr89Lys	missense variant	-	NC_000013.11:g.94590900G>T	ExAC,TOPMed,gnomAD
rs724160004	p.Glu90Gly	missense variant	-	NC_000013.11:g.94590897T>C	ExAC,TOPMed,gnomAD
RCV000149819	p.Glu90Gly	missense variant	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94590897T>C	ClinVar
rs777933953	p.Glu90Lys	missense variant	-	NC_000013.11:g.94590898C>T	ExAC,gnomAD
COSM264019	p.Glu90Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94590896C>A	NCI-TCGA Cosmic
RCV000149821	p.Lys91Ter	frameshift	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94590896_94590897CT[1]	ClinVar
rs765371325	p.Ile94Met	missense variant	-	NC_000013.11:g.94590884T>C	ExAC,TOPMed,gnomAD
rs1429058726	p.Ile94Thr	missense variant	-	NC_000013.11:g.94590885A>G	gnomAD
rs753002918	p.Ile94Val	missense variant	-	NC_000013.11:g.94590886T>C	ExAC,gnomAD
RCV000622534	p.Leu96Ile	missense variant	Inborn genetic diseases	NC_000013.11:g.94590880G>T	ClinVar
rs754214510	p.Leu96Ile	missense variant	-	NC_000013.11:g.94590880G>T	ExAC,gnomAD
rs770771817	p.His97Tyr	missense variant	-	NC_000013.11:g.94590877G>A	gnomAD
rs727502808	p.Phe98Leu	missense variant	-	NC_000013.11:g.94590872A>C	TOPMed,gnomAD
RCV000149820	p.Phe98Leu	missense variant	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94590872A>C	ClinVar
rs1267159417	p.Ala99Val	missense variant	-	NC_000013.11:g.94590870G>A	TOPMed
rs140430952	p.Ala100Thr	missense variant	-	NC_000013.11:g.94590868C>T	ESP,ExAC,TOPMed,gnomAD
rs140430952	p.Ala100Ser	missense variant	-	NC_000013.11:g.94590868C>A	ESP,ExAC,TOPMed,gnomAD
rs140430952	p.Ala100Ser	missense variant	Catel-Manzke syndrome (CATMANS)	NC_000013.11:g.94590868C>A	UniProt,dbSNP
VAR_072684	p.Ala100Ser	missense variant	Catel-Manzke syndrome (CATMANS)	NC_000013.11:g.94590868C>A	UniProt
rs374669948	p.Ala100Val	missense variant	-	NC_000013.11:g.94590867G>A	ESP,ExAC,TOPMed,gnomAD
RCV000624586	p.Ala100Ser	missense variant	Inborn genetic diseases	NC_000013.11:g.94590868C>A	ClinVar
RCV000149817	p.Ala100Ser	missense variant	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94590868C>A	ClinVar
rs1264976815	p.Gln101Pro	missense variant	-	NC_000013.11:g.94590864T>G	TOPMed,gnomAD
rs775273838	p.Thr102Ile	missense variant	-	NC_000013.11:g.94590861G>A	ExAC,TOPMed,gnomAD
rs147139240	p.His103Pro	missense variant	-	NC_000013.11:g.94590858T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1461943144	p.His103Tyr	missense variant	-	NC_000013.11:g.94590859G>A	TOPMed
rs147139240	p.His103Arg	missense variant	-	NC_000013.11:g.94590858T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147139240	p.His103Leu	missense variant	-	NC_000013.11:g.94590858T>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs781164643	p.Val104Ile	missense variant	-	NC_000013.11:g.94590856C>T	ExAC
rs774871143	p.Asp105Glu	missense variant	-	NC_000013.11:g.94583235A>T	ExAC,TOPMed,gnomAD
rs1232200518	p.Ser107Pro	missense variant	-	NC_000013.11:g.94583231A>G	TOPMed,gnomAD
rs139304427	p.Val109Leu	missense variant	-	NC_000013.11:g.94583225C>A	ESP,ExAC,TOPMed,gnomAD
rs139304427	p.Val109Ile	missense variant	-	NC_000013.11:g.94583225C>T	ESP,ExAC,TOPMed,gnomAD
rs202068418	p.Arg110His	missense variant	-	NC_000013.11:g.94583221C>T	ExAC,TOPMed,gnomAD
rs746793935	p.Arg110Cys	missense variant	-	NC_000013.11:g.94583222G>A	ExAC,TOPMed,gnomAD
rs748051295	p.Ala111Gly	missense variant	-	NC_000013.11:g.94583218G>C	ExAC,gnomAD
rs771915710	p.Ala111Thr	missense variant	-	NC_000013.11:g.94583219C>T	ExAC,gnomAD
rs778886182	p.Glu113Ter	stop gained	-	NC_000013.11:g.94583213C>A	ExAC,gnomAD
rs189838148	p.Tyr116Cys	missense variant	-	NC_000013.11:g.94583203T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val117Ala	missense variant	-	NC_000013.11:g.94583200A>G	NCI-TCGA
rs559787839	p.Asn118Asp	missense variant	-	NC_000013.11:g.94583198T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs780215822	p.Asn118Ser	missense variant	-	NC_000013.11:g.94583197T>C	ExAC,TOPMed,gnomAD
rs375550384	p.Tyr120His	missense variant	-	NC_000013.11:g.94583192A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr120Cys	missense variant	-	NC_000013.11:g.94583191T>C	NCI-TCGA
rs368046527	p.Thr122Ile	missense variant	-	NC_000013.11:g.94583185G>A	ESP,ExAC,gnomAD
rs767859800	p.His123Gln	missense variant	-	NC_000013.11:g.94583181G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val124Gly	missense variant	-	NC_000013.11:g.94583179A>C	NCI-TCGA
rs757740323	p.Val124Ile	missense variant	-	NC_000013.11:g.94583180C>T	ExAC,gnomAD
rs1282092360	p.Val126Ile	missense variant	-	NC_000013.11:g.94583174C>T	TOPMed,gnomAD
rs1214002110	p.Ala129Thr	missense variant	-	NC_000013.11:g.94583165C>T	gnomAD
rs1352388212	p.Ala129Val	missense variant	-	NC_000013.11:g.94583164G>A	gnomAD
rs752056819	p.His130Tyr	missense variant	-	NC_000013.11:g.94583162G>A	ExAC,gnomAD
rs764890113	p.His130Arg	missense variant	-	NC_000013.11:g.94583161T>C	ExAC,gnomAD
rs1396984304	p.Val140Ile	missense variant	-	NC_000013.11:g.94583132C>T	gnomAD
COSM4048785	p.Val140Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94583131A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp143Asn	missense variant	-	NC_000013.11:g.94583123C>T	NCI-TCGA
rs776492009	p.Val145Ile	missense variant	-	NC_000013.11:g.94583117C>T	ExAC,TOPMed,gnomAD
rs1361360452	p.Gly148Asp	missense variant	-	NC_000013.11:g.94583107C>T	gnomAD
rs1014479540	p.Gly148Ser	missense variant	-	NC_000013.11:g.94583108C>T	TOPMed
rs76632425	p.Asp151Tyr	missense variant	-	NC_000013.11:g.94583099C>A	ExAC,TOPMed,gnomAD
rs76632425	p.Asp151Asn	missense variant	-	NC_000013.11:g.94583099C>T	ExAC,TOPMed,gnomAD
rs1168305530	p.Phe154Leu	missense variant	-	NC_000013.11:g.94581186A>G	TOPMed,gnomAD
rs753410304	p.Asp155Val	missense variant	-	NC_000013.11:g.94581182T>A	ExAC,TOPMed,gnomAD
rs753410304	p.Asp155Gly	missense variant	-	NC_000013.11:g.94581182T>C	ExAC,TOPMed,gnomAD
rs1442649493	p.Glu156Gly	missense variant	-	NC_000013.11:g.94581179T>C	TOPMed
rs765919204	p.Ser158Leu	missense variant	-	NC_000013.11:g.94581173G>A	ExAC,TOPMed,gnomAD
rs772868057	p.Gln161Glu	missense variant	-	NC_000013.11:g.94581165G>C	ExAC,TOPMed,gnomAD
rs772868057	p.Gln161Ter	stop gained	-	NC_000013.11:g.94581165G>A	ExAC,TOPMed,gnomAD
rs1266030268	p.Thr163Ala	missense variant	-	NC_000013.11:g.94581159T>C	TOPMed,gnomAD
rs767261051	p.Asn164His	missense variant	-	NC_000013.11:g.94581156T>G	ExAC,gnomAD
rs767261051	p.Asn164Asp	missense variant	-	NC_000013.11:g.94581156T>C	ExAC,gnomAD
rs761635228	p.Pro165Leu	missense variant	-	NC_000013.11:g.94581152G>A	ExAC,gnomAD
rs761635228	p.Pro165Arg	missense variant	-	NC_000013.11:g.94581152G>C	ExAC,gnomAD
rs1315778035	p.Tyr166His	missense variant	-	NC_000013.11:g.94581150A>G	TOPMed
rs774337095	p.Tyr166Cys	missense variant	-	NC_000013.11:g.94581149T>C	ExAC,gnomAD
rs749160631	p.Ala167Thr	missense variant	-	NC_000013.11:g.94581147C>T	ExAC,gnomAD
rs769873986	p.Ser168Ala	missense variant	-	NC_000013.11:g.94581144A>C	ExAC,gnomAD
NCI-TCGA novel	p.Ser169Cys	missense variant	-	NC_000013.11:g.94581140G>C	NCI-TCGA
NCI-TCGA novel	p.Ala172Asp	missense variant	-	NC_000013.11:g.94581131G>T	NCI-TCGA
COSM3399459	p.Cys175Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94581121A>C	NCI-TCGA Cosmic
rs1382743725	p.Val177Leu	missense variant	-	NC_000013.11:g.94581117C>A	TOPMed
rs1443138467	p.Gln178Pro	missense variant	-	NC_000013.11:g.94581113T>G	gnomAD
rs781446713	p.Gln178Ter	stop gained	-	NC_000013.11:g.94581114G>A	ExAC,gnomAD
rs771269493	p.Ser179Thr	missense variant	-	NC_000013.11:g.94581111A>T	ExAC,gnomAD
rs747362303	p.Tyr180Asn	missense variant	-	NC_000013.11:g.94581108A>T	ExAC,gnomAD
rs1244338556	p.Tyr180Cys	missense variant	-	NC_000013.11:g.94581107T>C	TOPMed
rs778224794	p.Tyr180Ter	stop gained	-	NC_000013.11:g.94581106G>C	ExAC,TOPMed,gnomAD
rs1419957473	p.Glu182Lys	missense variant	-	NC_000013.11:g.94581102C>T	gnomAD
rs370484533	p.Gln183Ter	stop gained	-	NC_000013.11:g.94581099G>A	ExAC,gnomAD
rs1044523436	p.Gln183Arg	missense variant	-	NC_000013.11:g.94581098T>C	TOPMed,gnomAD
rs1376678181	p.Lys185Thr	missense variant	-	NC_000013.11:g.94581092T>G	gnomAD
rs1376678181	p.Lys185Arg	missense variant	-	NC_000013.11:g.94581092T>C	gnomAD
NCI-TCGA novel	p.Pro187Ser	missense variant	-	NC_000013.11:g.94579950G>A	NCI-TCGA
rs1183728299	p.Val188Phe	missense variant	-	NC_000013.11:g.94579947C>A	TOPMed
rs375494440	p.Thr191Ile	missense variant	-	NC_000013.11:g.94579937G>A	ESP,ExAC,TOPMed,gnomAD
rs748710870	p.Ser193Asn	missense variant	-	NC_000013.11:g.94579931C>T	ExAC,TOPMed,gnomAD
rs1351650281	p.Pro199Ala	missense variant	-	NC_000013.11:g.94579914G>C	gnomAD
rs1285368015	p.Pro199Leu	missense variant	-	NC_000013.11:g.94579913G>A	gnomAD
rs755643462	p.Gln201His	missense variant	-	NC_000013.11:g.94579906T>G	ExAC,gnomAD
rs1430841344	p.Gln201Ter	stop gained	-	NC_000013.11:g.94579908G>A	TOPMed
rs755643462	p.Gln201His	missense variant	-	NC_000013.11:g.94579906T>A	ExAC,gnomAD
COSM432617	p.Glu204Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94579899C>T	NCI-TCGA Cosmic
rs774775351	p.Val206Ile	missense variant	-	NC_000013.11:g.94578773C>T	ExAC,gnomAD
NCI-TCGA novel	p.Phe210Val	missense variant	-	NC_000013.11:g.94578761A>C	NCI-TCGA
rs1156262519	p.Ile211Met	missense variant	-	NC_000013.11:g.94578756T>C	TOPMed
rs1471988957	p.Ile211Lys	missense variant	-	NC_000013.11:g.94578757A>T	TOPMed
rs769212951	p.Leu213Ser	missense variant	-	NC_000013.11:g.94578751A>G	ExAC,gnomAD
rs749721449	p.Leu213Phe	missense variant	-	NC_000013.11:g.94578750C>A	ExAC,gnomAD
rs1405265903	p.Gln215Ter	stop gained	-	NC_000013.11:g.94578746G>A	gnomAD
rs1416599590	p.Asn217Asp	missense variant	-	NC_000013.11:g.94578740T>C	TOPMed
NCI-TCGA novel	p.Arg218Trp	missense variant	-	NC_000013.11:g.94578737T>A	NCI-TCGA
COSM3417740	p.Arg218Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94578736C>A	NCI-TCGA Cosmic
rs1419150789	p.Lys219Arg	missense variant	-	NC_000013.11:g.94578733T>C	gnomAD
rs1167558041	p.Cys220Arg	missense variant	-	NC_000013.11:g.94578731A>G	gnomAD
rs777210874	p.Cys221Ser	missense variant	-	NC_000013.11:g.94578168C>G	ExAC,TOPMed,gnomAD
rs758048181	p.Ile222Asn	missense variant	-	NC_000013.11:g.94578165A>T	ExAC,gnomAD
rs1233005543	p.His223Arg	missense variant	-	NC_000013.11:g.94578162T>C	gnomAD
COSM5068857	p.Ser225Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94578157A>G	NCI-TCGA Cosmic
rs753854206	p.Gln228Pro	missense variant	-	NC_000013.11:g.94578147T>G	ExAC,gnomAD
NCI-TCGA novel	p.Gln228Ter	stop gained	-	NC_000013.11:g.94578148G>A	NCI-TCGA
rs766413844	p.Thr229Pro	missense variant	-	NC_000013.11:g.94578145T>G	ExAC,gnomAD
rs1183007382	p.Thr229Arg	missense variant	-	NC_000013.11:g.94578144G>C	TOPMed
rs756319678	p.Arg230Gly	missense variant	-	NC_000013.11:g.94578142T>C	ExAC,TOPMed,gnomAD
rs1357654176	p.Asn231Ser	missense variant	-	NC_000013.11:g.94578138T>C	gnomAD
rs544436734	p.Tyr234His	missense variant	Catel-Manzke syndrome (CATMANS)	NC_000013.11:g.94578130A>G	UniProt,dbSNP
VAR_072685	p.Tyr234His	missense variant	Catel-Manzke syndrome (CATMANS)	NC_000013.11:g.94578130A>G	UniProt
rs544436734	p.Tyr234His	missense variant	-	NC_000013.11:g.94578130A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs762149592	p.Tyr234Phe	missense variant	-	NC_000013.11:g.94578129T>A	ExAC,gnomAD
rs762149592	p.Tyr234Cys	missense variant	-	NC_000013.11:g.94578129T>C	ExAC,gnomAD
RCV000149818	p.Tyr234His	missense variant	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94578130A>G	ClinVar
rs1396930499	p.Thr236Ala	missense variant	-	NC_000013.11:g.94578124T>C	gnomAD
rs374757364	p.Asp237His	missense variant	-	NC_000013.11:g.94578121C>G	ESP,ExAC,TOPMed,gnomAD
rs374757364	p.Asp237Asn	missense variant	-	NC_000013.11:g.94578121C>T	ESP,ExAC,TOPMed,gnomAD
rs927214872	p.Ala241Thr	missense variant	-	NC_000013.11:g.94578109C>T	TOPMed,gnomAD
rs1177575428	p.Phe242Leu	missense variant	-	NC_000013.11:g.94578106A>G	gnomAD
rs763227888	p.Leu243Pro	missense variant	-	NC_000013.11:g.94578102A>G	ExAC,gnomAD
rs776126290	p.Val245Ile	missense variant	-	NC_000013.11:g.94578097C>T	ExAC,gnomAD
rs1171446283	p.Lys247Arg	missense variant	-	NC_000013.11:g.94578090T>C	TOPMed
COSM5070111	p.Gly249Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94578085C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro251Ser	missense variant	-	NC_000013.11:g.94578079G>A	NCI-TCGA
NCI-TCGA novel	p.Ile254Met	missense variant	-	NC_000013.11:g.94578068A>C	NCI-TCGA
rs1348044163	p.Tyr255Cys	missense variant	-	NC_000013.11:g.94578066T>C	gnomAD
NCI-TCGA novel	p.Asn256Lys	missense variant	-	NC_000013.11:g.94578062G>T	NCI-TCGA
rs1372035000	p.Ile257Val	missense variant	-	NC_000013.11:g.94578061T>C	TOPMed
rs1335693810	p.Gly258Arg	missense variant	-	NC_000013.11:g.94578058C>T	gnomAD
rs772737712	p.Phe261Tyr	missense variant	-	NC_000013.11:g.94578048A>T	ExAC,TOPMed,gnomAD
rs771518626	p.Met263Val	missense variant	-	NC_000013.11:g.94578043T>C	ExAC,gnomAD
rs747879381	p.Ser264Ter	stop gained	-	NC_000013.11:g.94578039G>C	ExAC,gnomAD
NCI-TCGA novel	p.Gln267Ter	stop gained	-	NC_000013.11:g.94578031G>A	NCI-TCGA
rs778393818	p.Leu268Val	missense variant	-	NC_000013.11:g.94578028G>C	ExAC,TOPMed,gnomAD
rs971659298	p.Ala269Val	missense variant	-	NC_000013.11:g.94578024G>A	TOPMed
rs768562809	p.Glu271Ala	missense variant	-	NC_000013.11:g.94578018T>G	ExAC,gnomAD
rs1453061175	p.Glu271Asp	missense variant	-	NC_000013.11:g.94578017T>G	gnomAD
NCI-TCGA novel	p.Glu271Ter	stop gained	-	NC_000013.11:g.94578019C>A	NCI-TCGA
rs575808762	p.Leu272Gln	missense variant	-	NC_000013.11:g.94578015A>T	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Leu272Pro	missense variant	-	NC_000013.11:g.94578015A>G	NCI-TCGA
rs779935345	p.Ile273Thr	missense variant	-	NC_000013.11:g.94578012A>G	ExAC
rs756123613	p.Ile273Met	missense variant	-	NC_000013.11:g.94578011T>C	ExAC,gnomAD
rs140589210	p.Gln274Glu	missense variant	-	NC_000013.11:g.94578010G>C	ESP,ExAC,TOPMed,gnomAD
rs140589210	p.Gln274Lys	missense variant	-	NC_000013.11:g.94578010G>T	ESP,ExAC,TOPMed,gnomAD
rs140589210	p.Gln274Ter	stop gained	-	NC_000013.11:g.94578010G>A	ESP,ExAC,TOPMed,gnomAD
rs546237136	p.Glu278Asp	missense variant	-	NC_000013.11:g.94577421C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs529621348	p.Thr279Pro	missense variant	-	NC_000013.11:g.94577420T>G	1000Genomes,ExAC,gnomAD
rs757419656	p.Asn280Ser	missense variant	-	NC_000013.11:g.94577416T>C	ExAC,TOPMed,gnomAD
rs1176849709	p.Asn280Lys	missense variant	-	NC_000013.11:g.94577415A>T	gnomAD
rs560513141	p.Glu284Ala	missense variant	-	NC_000013.11:g.94577404T>G	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Met285Ile	missense variant	-	NC_000013.11:g.94577400C>A	NCI-TCGA
COSM948923	p.Met285Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94577402T>C	NCI-TCGA Cosmic
rs1231705469	p.Glu286Lys	missense variant	-	NC_000013.11:g.94577399C>T	TOPMed
rs1337402058	p.Trp288Cys	missense variant	-	NC_000013.11:g.94577391C>A	gnomAD
NCI-TCGA novel	p.Trp288LeuPheSerTerUnk	frameshift	-	NC_000013.11:g.94577392_94577393insA	NCI-TCGA
NCI-TCGA novel	p.Val289Ile	missense variant	-	NC_000013.11:g.94577390C>T	NCI-TCGA
COSM4048783	p.Val289Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000013.11:g.94577389A>G	NCI-TCGA Cosmic
rs544524588	p.Tyr291Phe	missense variant	-	NC_000013.11:g.94577383T>A	1000Genomes
rs1276588170	p.Val292Phe	missense variant	-	NC_000013.11:g.94577381C>A	gnomAD
rs758582500	p.Asp294His	missense variant	-	NC_000013.11:g.94577375C>G	ExAC,gnomAD
rs724160005	p.Asn298Asp	missense variant	-	NC_000013.11:g.94576404T>C	-
rs769779710	p.Asn298Ser	missense variant	-	NC_000013.11:g.94576403T>C	ExAC,TOPMed,gnomAD
RCV000149822	p.Asn298Asp	missense variant	Catel Manzke syndrome (CATMANS)	NC_000013.11:g.94576404T>C	ClinVar
rs376831797	p.Asp299Asn	missense variant	-	NC_000013.11:g.94576401C>T	ESP,ExAC,TOPMed,gnomAD
rs1396784266	p.Asp299Val	missense variant	-	NC_000013.11:g.94576400T>A	gnomAD
rs376831797	p.Asp299Tyr	missense variant	-	NC_000013.11:g.94576401C>A	ESP,ExAC,TOPMed,gnomAD
rs1393932328	p.Met300Ile	missense variant	-	NC_000013.11:g.94576396C>A	gnomAD
rs1169271255	p.Met300Val	missense variant	-	NC_000013.11:g.94576398T>C	gnomAD
rs1432373497	p.Met300Thr	missense variant	-	NC_000013.11:g.94576397A>G	gnomAD
rs1181560124	p.Met304Thr	missense variant	-	NC_000013.11:g.94576385A>G	gnomAD
rs1438743391	p.Met304Ile	missense variant	-	NC_000013.11:g.94576384C>A	TOPMed,gnomAD
rs367576453	p.Met304Val	missense variant	-	NC_000013.11:g.94576386T>C	ESP,ExAC,TOPMed,gnomAD
rs1438743391	p.Met304Ile	missense variant	-	NC_000013.11:g.94576384C>T	TOPMed,gnomAD
rs777740428	p.Lys305Gln	missense variant	-	NC_000013.11:g.94576383T>G	ExAC,TOPMed,gnomAD
rs748405605	p.His310Arg	missense variant	-	NC_000013.11:g.94576367T>C	ExAC,TOPMed,gnomAD
rs1281154644	p.His310Tyr	missense variant	-	NC_000013.11:g.94576368G>A	gnomAD
rs138907959	p.Leu312Phe	missense variant	-	NC_000013.11:g.94576360T>A	ESP,TOPMed
rs1369644811	p.Gly313Arg	missense variant	-	NC_000013.11:g.94576359C>T	gnomAD
rs1277639459	p.Gly313Val	missense variant	-	NC_000013.11:g.94576358C>A	TOPMed,gnomAD
rs144948056	p.Trp314Arg	missense variant	-	NC_000013.11:g.94576356A>G	ESP,TOPMed,gnomAD
rs144948056	p.Trp314Arg	missense variant	-	NC_000013.11:g.94576356A>T	ESP,TOPMed,gnomAD
rs779098313	p.Arg315Ter	stop gained	-	NC_000013.11:g.94576353T>A	ExAC,TOPMed,gnomAD
rs755393384	p.Pro316Arg	missense variant	-	NC_000013.11:g.94576349G>C	ExAC,gnomAD
rs755393384	p.Pro316His	missense variant	-	NC_000013.11:g.94576349G>T	ExAC,gnomAD
rs1284224643	p.Lys317Asn	missense variant	-	NC_000013.11:g.94576345T>G	gnomAD
rs1235127517	p.Pro319Arg	missense variant	-	NC_000013.11:g.94576340G>C	TOPMed
rs1374436495	p.Lys321Glu	missense variant	-	NC_000013.11:g.94576335T>C	gnomAD
rs1173723601	p.Glu322Lys	missense variant	-	NC_000013.11:g.94576332C>T	gnomAD
rs1435981482	p.Gly323Glu	missense variant	-	NC_000013.11:g.94576328C>T	gnomAD
rs1158497257	p.Ile324Met	missense variant	-	NC_000013.11:g.94576324T>C	gnomAD
rs1406502881	p.Ile324Leu	missense variant	-	NC_000013.11:g.94576326T>G	gnomAD
rs756608932	p.Lys325Asn	missense variant	-	NC_000013.11:g.94576321C>A	ExAC,TOPMed,gnomAD
rs752263870	p.Trp330Ter	stop gained	-	NC_000013.11:g.94574845C>T	ExAC,gnomAD
rs764804060	p.His336Tyr	missense variant	-	NC_000013.11:g.94574829G>A	ExAC,gnomAD
rs1359364582	p.Asn337Ser	missense variant	-	NC_000013.11:g.94574825T>C	gnomAD
rs1359364582	p.Asn337Thr	missense variant	-	NC_000013.11:g.94574825T>G	gnomAD
rs759286853	p.Lys339Asn	missense variant	-	NC_000013.11:g.94574818C>G	ExAC,gnomAD
rs1335818690	p.Asn340Asp	missense variant	-	NC_000013.11:g.94574817T>C	TOPMed,gnomAD
rs1430735190	p.Glu342Gly	missense variant	-	NC_000013.11:g.94574810T>C	TOPMed,gnomAD
rs753509890	p.Lys343Ter	stop gained	-	NC_000013.11:g.94574808T>A	ExAC,gnomAD
rs1442713093	p.Lys343Asn	missense variant	-	NC_000013.11:g.94574806C>A	gnomAD
rs1461310508	p.Ala344Thr	missense variant	-	NC_000013.11:g.94574805C>T	TOPMed,gnomAD
rs766124794	p.Phe348Tyr	missense variant	-	NC_000013.11:g.94574792A>T	ExAC,gnomAD
rs533417105	p.Pro349Leu	missense variant	-	NC_000013.11:g.94574789G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs772009375	p.Val350Ile	missense variant	-	NC_000013.11:g.94574787C>T	ExAC,TOPMed,gnomAD
rs772009375	p.Val350Leu	missense variant	-	NC_000013.11:g.94574787C>A	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0003492	Aortic coarctation	disease	HPO
C0008924	Cleft upper lip	disease	HPO
C0009081	Congenital clubfoot	disease	HPO
C0010417	Cryptorchidism	disease	HPO
C0011813	Dextrocardia	disease	HPO
C0011818	Dextraposition of aorta	disease	HPO
C0012691	Dislocations	group	HPO
C0014544	Epilepsy	disease	HPO
C0015934	Fetal Growth Retardation	phenotype	HPO
C0018818	Ventricular Septal Defects	group	HPO
C0019294	Hernia, Inguinal	phenotype	HPO
C0019322	Umbilical hernia	phenotype	HPO
C0021296	Infant, Small for Gestational Age	phenotype	HPO
C0025990	Micrognathism	disease	HPO
C0036572	Seizures	phenotype	HPO
C0037932	Curvature of spine	phenotype	HPO
C0086437	Joint laxity	phenotype	HPO
C0158731	Congenital pectus carinatum	disease	HPO
C0162298	Joint stiffness	phenotype	HPO
C0206620	Lymphangioma, Cystic	disease	HPO
C0231246	Failure to gain weight	phenotype	HPO
C0239234	Low set ears	phenotype	HPO
C0240635	Byzanthine arch palate	disease	HPO
C0265886	Overriding aorta	disease	HPO
C0267048	Glossoptosis	disease	HPO
C0271441	Chronic otitis media	disease	HPO
C0349588	Short stature	phenotype	HPO
C0424731	Single transverse palmar crease	phenotype	HPO
C0431483	Simple ear	phenotype	HPO
C0521525	Short neck	phenotype	HPO
C0557874	Global developmental delay	disease	HPO
C0685409	Congenital Camptodactyly	disease	HPO
C0700208	Acquired scoliosis	phenotype	HPO
C0743359	Chronic ear infection	disease	HPO
C0857379	Abnormality of the pinna	phenotype	HPO
C0950123	Genetic Diseases, Inborn	group	CLINVAR
C1386048	Intrauterine retardation	phenotype	HPO
C1844887	Catel Manzke syndrome	disease	BEFREE;CLINVAR;CTD_human;ORPHANET;UNIPROT
C1844891	Ulnar deviation of the 2nd finger	phenotype	HPO
C1850049	Clinodactyly of the 5th finger	disease	HPO
C1857130	Hypoplastic mandible condyle	phenotype	HPO
C1857486	Low-set, posteriorly rotated ears	phenotype	HPO
C1858085	Malar flattening	phenotype	HPO
C1859778	Postnatal growth retardation	phenotype	HPO
C1864897	Cognitive delay	phenotype	HPO
C1866231	Full cheeks	phenotype	HPO
C1868571	Highly arched eyebrow	phenotype	HPO
C2051831	Pectus excavatum	phenotype	HPO
C2315100	Pediatric failure to thrive	disease	HPO
C2748653	Chubby cheeks	phenotype	HPO
C2981150	Uranostaphyloschisis	disease	HPO
C3714756	Intellectual Disability	group	GENOMICS_ENGLAND
C3806443	Puffy cheeks	phenotype	HPO
C4020849	Bowed and upward slanting eyebrows	phenotype	HPO
C4020875	Mental and motor retardation	phenotype	HPO
C4021611	Abnormality of epiphysis morphology	phenotype	HPO
C4024589	Aplasia/Hypoplasia of the mandible	phenotype	HPO
C4072907	Hyperphalangy of the 2nd finger	phenotype	HPO
C4280538	Curvature of little finger	phenotype	HPO
C4280647	Hypertrophy of cheeks	phenotype	HPO
C4280648	Hyperplasia of cheeks	phenotype	HPO
C4280651	Hypotrophic malar bone	phenotype	HPO
C4280678	Posterior displacement of the tongue	phenotype	HPO
C4476523	Decreased projection of lower jaw	phenotype	HPO
C4476524	Decreased projection of mandible	phenotype	HPO
C4476525	Retrusion of lower jaw	phenotype	HPO
C4531021	Undergrowth	phenotype	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0008460	dTDP-glucose 4,6-dehydratase activity	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0009225	nucleotide-sugar metabolic process	IEA

GO:Cellular Component

GO ID	GO Term	Evidence

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of TGDS mRNA	19095052
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGDS mRNA	20018196
C496492	abrine	abrine results in increased expression of TGDS mRNA	31054353
D000082	Acetaminophen	Acetaminophen affects the expression of TGDS mRNA	17562736
D016607	Aflatoxin M1	Aflatoxin M1 results in decreased expression of TGDS mRNA	30928695
D001280	Atrazine	Atrazine results in increased expression of TGDS mRNA	25929836
C044887	beta-methylcholine	beta-methylcholine affects the expression of TGDS mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of TGDS mRNA	27685785
C006780	bisphenol A	bisphenol A results in increased expression of TGDS mRNA	25181051; 27571134;
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TGDS mRNA	23650126
D016572	Cyclosporine	Cyclosporine results in increased expression of TGDS mRNA	20106945; 25562108;
C000944	dicrotophos	dicrotophos results in decreased expression of TGDS mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of TGDS mRNA	18042831
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of TGDS mRNA	21453500
D005047	Etoposide	TGDS protein affects the susceptibility to Etoposide	16217747
D005485	Flutamide	Flutamide results in increased expression of TGDS mRNA	24793618
D007213	Indomethacin	Indomethacin results in increased expression of TGDS mRNA	28201806
C544151	jinfukang	jinfukang results in decreased expression of TGDS mRNA	27392435
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TGDS mRNA	23649840
D016685	Mitomycin	TGDS protein affects the susceptibility to Mitomycin	16217747
D009243	NAD	NAD binds to and results in increased activity of TGDS protein	25526675
D000073878	Palm Oil	Palm Oil results in increased expression of TGDS mRNA	18042831
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TGDS mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of TGDS mRNA	27153767
D010634	Phenobarbital	Phenobarbital affects the expression of TGDS mRNA	19159669
C006253	pirinixic acid	pirinixic acid results in increased expression of TGDS mRNA	18301758
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TGDS mRNA	28903501
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of TGDS mRNA	21453500
D000077210	Sunitinib	Sunitinib results in increased expression of TGDS mRNA	31533062
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TGDS mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TGDS mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TGDS mRNA	16922920
C009495	titanium dioxide	titanium dioxide results in decreased expression of TGDS mRNA	29264374
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TGDS mRNA	26179874
D014415	Tunicamycin	Tunicamycin results in increased expression of TGDS mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of TGDS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TGDS mRNA	23179753
D014750	Vincristine	Vincristine results in increased expression of TGDS mRNA	23649840
D015032	Zinc	Zinc deficiency results in decreased expression of TGDS mRNA	22171008

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0225	Disease mutation
KW-0456	Lyase
KW-0520	NAD
KW-0621	Polymorphism
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR005888	dTDP_Gluc_deHydtase
IPR016040	NAD(P)-bd_dom
IPR036291	NAD(P)-bd_dom_sf

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF16363	GDP_Man_Dehyd

Gene: TGDS

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction