| Tag | Content |
|---|---|
| Uniprot ID | P01344; B3KX48; B7WP08; C9JAF2; E3UN45; P78449; Q14299; Q1WM26; Q9UC68; Q9UC69; |
| Entrez ID | 3481 |
| Genbank protein ID | CAA27156.1; AAA52536.1; AAB34155.1; BAG54360.1; ADO21454.1; CAA27249.1; AAM51825.1; AAA52443.1; CAA29517.1; CAA30717.1; CAA25426.1; ABD93451.1; AAH00531.1; AAA52545.1; AAA52544.1; AAA60088.1; AAP35659.1; CAA27157.1; EAX02485.1; CAA27155.1; CAA29516.1; CAA29518.1; AAG17220.1; |
| Genbank nucleotide ID | NM_001291861.2; NM_001007139.5; NM_001291862.2; NM_000612.5; NM_001127598.2; |
| Ensembl protein ID | ENSP00000370799; ENSP00000370796; ENSP00000370813; ENSP00000370802; ENSP00000391826; ENSP00000414497; ENSP00000402047; |
| Ensembl nucleotide ID | ENSG00000167244 |
| Gene name | Insulin-like growth factor II |
| Gene symbol | IGF2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). |
| Sequence | MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS 60 RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK 120 QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK 180 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.