Gene: TP53

Basic information

Tag Content
Uniprot ID P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61;
Entrez ID 7157
Genbank protein ID AAF36356.1; CAA42630.1; ABA29757.1; AAF63442.1; AAA61212.1; CAA42627.1; AAF36358.1; AAF36379.1; CAA42635.1; AAF36359.1; AAK76359.1; CAA26306.1; AAA59987.1; AAA59989.1; AAF36362.1; CAA42626.1; ABA29756.1; ABB80266.1; AAR10356.1; AAF36377.1; AAK76358.1; CAA42632.1; CAA42634.1; AAF36355.1; BAG35463.1; ABA29754.1; CAA42631.1; AAC12971.1; AAF36376.1; AAF36360.1; EAW90144.1; CAA42633.1; CAA42629.1; AAF36378.1; AAQ90158.1; AAA59988.1; AAF36357.1; AAD28628.1; AAF36381.1; AAP30003.1; CAA38095.1; AAF36375.1; BAC16799.1; AAF63443.1; AAF36374.1; AAF36354.1; ABA29755.1; AAG28785.1; CAA25652.1; AAR13239.1; AAB39322.1; AAH03596.1; AAF36361.1; EAW90143.1; AAF36382.1; CAA42628.1; AAD28535.1; AAA61211.1; ABB80262.1; AAF36380.1; AAV80424.1; ABA29753.1;
Genbank nucleotide ID NM_001126116.1; NM_001276697.1; NM_001276761.1; NM_001126112.2; NM_001276699.1; NM_001126118.1; NM_001276695.1; NM_001276698.1; NM_001276760.1; NM_001126114.2; NM_001126113.2; NM_000546.5; NM_001126117.1; NM_001126115.1; NM_001276696.1;
Ensembl protein ID ENSP00000481638; ENSP00000480868; ENSP00000482222; ENSP00000478219; ENSP00000482258; ENSP00000484409; ENSP00000391478; ENSP00000391127; ENSP00000481179; ENSP00000482537; ENSP00000398846; ENSP00000269305; ENSP00000478499;
Ensembl nucleotide ID ENSG00000141510
Gene name Cellular tumor antigen p53
Gene symbol TP53
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Sequence
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 60
DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 120
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 180
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 240
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 300
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG 360
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD 393

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTP53281542P67939Bos taurusPredictionMore>>
1:1 orthologTP53A0A452G0L9Capra hircusPredictionMore>>
1:1 orthologTP537157P04637Homo sapiensPredictionMore>>
1:1 orthologTp5322059P02340CPO,CLPMus musculusPublicationMore>>
1:1 orthologTP53455214H2QC53Pan troglodytesPredictionMore>>
1:1 orthologTP53G1SEU0Oryctolagus cuniculusPredictionMore>>
1:1 orthologTp53M0R497Rattus norvegicusPredictionMore>>
1:1 orthologtp5330590G1K2L5Danio rerioPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingISS
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingIDA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificISA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificIDA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificISM
GO:0001046 core promoter sequence-specific DNA bindingIDA
GO:0001085 RNA polymerase II transcription factor bindingIPI
GO:0001094 TFIID-class transcription factor complex bindingIPI
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIDA
GO:0002020 protease bindingIPI
GO:0002039 p53 bindingIPI
GO:0003677 DNA bindingIDA
GO:0003677 DNA bindingIMP
GO:0003682 chromatin bindingIDA
GO:0003700 DNA-binding transcription factor activityIMP
GO:0003700 DNA-binding transcription factor activityIDA
GO:0003730 mRNA 3'-UTR bindingIDA
GO:0005507 copper ion bindingIDA
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingIDA
GO:0008134 transcription factor bindingIPI
GO:0008270 zinc ion bindingTAS
GO:0019899 enzyme bindingIPI
GO:0019901 protein kinase bindingIPI
GO:0019903 protein phosphatase bindingIPI
GO:0030971 receptor tyrosine kinase bindingIPI
GO:0031625 ubiquitin protein ligase bindingIPI
GO:0035033 histone deacetylase regulator activityIEA
GO:0035035 histone acetyltransferase bindingIPI
GO:0042802 identical protein bindingIPI
GO:0042826 histone deacetylase bindingIPI
GO:0043621 protein self-associationIPI
GO:0044212 transcription regulatory region DNA bindingIDA
GO:0046982 protein heterodimerization activityIPI
GO:0047485 protein N-terminus bindingIPI
GO:0051087 chaperone bindingIPI
GO:0051721 protein phosphatase 2A bindingIPI
GO:0097371 MDM2/MDM4 family protein bindingIEA
GO:0097718 disordered domain specific bindingIPI
GO:1990841 promoter-specific chromatin bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISS
GO:0000733 DNA strand renaturationIDA
GO:0001701 in utero embryonic developmentIEA
GO:0001756 somitogenesisIEA
GO:0001836 release of cytochrome c from mitochondriaIEA
GO:0002244 hematopoietic progenitor cell differentiationIMP
GO:0002309 T cell proliferation involved in immune responseIEA
GO:0002326 B cell lineage commitmentIEA
GO:0002360 T cell lineage commitmentIEA
GO:0002931 response to ischemiaIEA
GO:0006289 nucleotide-excision repairIMP
GO:0006302 double-strand break repairIEA
GO:0006355 regulation of transcription, DNA-templatedIMP
GO:0006355 regulation of transcription, DNA-templatedIDA
GO:0006606 protein import into nucleusIEA
GO:0006914 autophagyIMP
GO:0006974 cellular response to DNA damage stimulusIDA
GO:0006974 cellular response to DNA damage stimulusIMP
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIMP
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAS
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDA
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIMP
GO:0006983 ER overload responseIDA
GO:0007050 cell cycle arrestIMP
GO:0007050 cell cycle arrestIDA
GO:0007179 transforming growth factor beta receptor signaling pathwayIEA
GO:0007265 Ras protein signal transductionIEP
GO:0007369 gastrulationIEA
GO:0007406 negative regulation of neuroblast proliferationIEA
GO:0007569 cell agingIMP
GO:0008104 protein localizationIDA
GO:0008156 negative regulation of DNA replicationIEA
GO:0008285 negative regulation of cell population proliferationISS
GO:0008285 negative regulation of cell population proliferationIMP
GO:0008285 negative regulation of cell population proliferationIDA
GO:0008340 determination of adult lifespanISS
GO:0009299 mRNA transcriptionIMP
GO:0009303 rRNA transcriptionIEA
GO:0009651 response to salt stressIEA
GO:0010165 response to X-rayIEA
GO:0010332 response to gamma radiationIMP
GO:0010628 positive regulation of gene expressionISS
GO:0010628 positive regulation of gene expressionIDA
GO:0010628 positive regulation of gene expressionIMP
GO:0010666 positive regulation of cardiac muscle cell apoptotic processIEA
GO:0016032 viral processIMP
GO:0016579 protein deubiquitinationTAS
GO:0019221 cytokine-mediated signaling pathwayTAS
GO:0021549 cerebellum developmentIEA
GO:0030308 negative regulation of cell growthIMP
GO:0030330 DNA damage response, signal transduction by p53 class mediatorIDA
GO:0030330 DNA damage response, signal transduction by p53 class mediatorIMP
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathwayIEA
GO:0031065 positive regulation of histone deacetylationIEA
GO:0031497 chromatin assemblyIDA
GO:0031571 mitotic G1 DNA damage checkpointIMP
GO:0033077 T cell differentiation in thymusIEA
GO:0034103 regulation of tissue remodelingIEA
GO:0034644 cellular response to UVIDA
GO:0035264 multicellular organism growthIEA
GO:0035690 cellular response to drugIEP
GO:0035794 positive regulation of mitochondrial membrane permeabilityIEA
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stressIDA
GO:0042149 cellular response to glucose starvationIDA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDA
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMP
GO:0042981 regulation of apoptotic processIDA
GO:0042981 regulation of apoptotic processTAS
GO:0043065 positive regulation of apoptotic processIDA
GO:0043066 negative regulation of apoptotic processIMP
GO:0043153 entrainment of circadian clock by photoperiodISS
GO:0043504 mitochondrial DNA repairIEA
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediatorIEA
GO:0043525 positive regulation of neuron apoptotic processIEA
GO:0045861 negative regulation of proteolysisIEA
GO:0045892 negative regulation of transcription, DNA-templatedISS
GO:0045892 negative regulation of transcription, DNA-templatedIMP
GO:0045892 negative regulation of transcription, DNA-templatedIDA
GO:0045893 positive regulation of transcription, DNA-templatedIDA
GO:0045893 positive regulation of transcription, DNA-templatedIMP
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assemblyIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0046677 response to antibioticIEP
GO:0046827 positive regulation of protein export from nucleusTAS
GO:0048147 negative regulation of fibroblast proliferationIMP
GO:0048512 circadian behaviorISS
GO:0048539 bone marrow developmentIMP
GO:0048568 embryonic organ developmentIEA
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylationISS
GO:0050821 protein stabilizationIEA
GO:0051097 negative regulation of helicase activityTAS
GO:0051123 RNA polymerase II preinitiation complex assemblyIDA
GO:0051262 protein tetramerizationIEA
GO:0051402 neuron apoptotic processIEA
GO:0051974 negative regulation of telomerase activityIDA
GO:0060218 hematopoietic stem cell differentiationIMP
GO:0060333 interferon-gamma-mediated signaling pathwayIEA
GO:0060411 cardiac septum morphogenesisIEA
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaIEA
GO:0062100 positive regulation of programmed necrotic cell deathIEA
GO:0065003 protein-containing complex assemblyIDA
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEA
GO:0070245 positive regulation of thymocyte apoptotic processISS
GO:0070266 necroptotic processIEA
GO:0071158 positive regulation of cell cycle arrestIDA
GO:0071158 positive regulation of cell cycle arrestIMP
GO:0071456 cellular response to hypoxiaIEP
GO:0071479 cellular response to ionizing radiationIMP
GO:0071480 cellular response to gamma radiationIDA
GO:0071494 cellular response to UV-CIEA
GO:0071850 mitotic cell cycle arrestIEA
GO:0072331 signal transduction by p53 class mediatorIDA
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediatorIMP
GO:0072717 cellular response to actinomycin DIDA
GO:0090200 positive regulation of release of cytochrome c from mitochondriaIDA
GO:0090343 positive regulation of cell agingIEA
GO:0090399 replicative senescenceIMP
GO:0090403 oxidative stress-induced premature senescenceIMP
GO:0097193 intrinsic apoptotic signaling pathwayTAS
GO:0097252 oligodendrocyte apoptotic processIDA
GO:1900119 positive regulation of execution phase of apoptosisIMP
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:1901525 negative regulation of mitophagyIEA
GO:1901796 regulation of signal transduction by p53 class mediatorTAS
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic processIEA
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA
GO:1902749 regulation of cell cycle G2/M phase transitionTAS
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase IIIDA
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNAIEA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNAIDA
GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvateIEA
GO:1905856 negative regulation of pentose-phosphate shuntIMP
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxiaIEA
GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damageIDA
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressISS
GO:2000269 regulation of fibroblast apoptotic processIEA
GO:2000378 negative regulation of reactive oxygen species metabolic processIEA
GO:2000379 positive regulation of reactive oxygen species metabolic processIMP
GO:2000772 regulation of cellular senescenceIEA
GO:2001244 positive regulation of intrinsic apoptotic signaling pathwayISS
GO:2001244 positive regulation of intrinsic apoptotic signaling pathwayIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0000790 nuclear chromatinISA
GO:0000790 nuclear chromatinIDA
GO:0000790 nuclear chromatinIMP
GO:0005634 nucleusIDA
GO:0005634 nucleusIMP
GO:0005654 nucleoplasmIDA
GO:0005654 nucleoplasmTAS
GO:0005657 replication forkIEA
GO:0005667 transcription factor complexIGI
GO:0005730 nucleolusIDA
GO:0005737 cytoplasmIDA
GO:0005737 cytoplasmIMP
GO:0005739 mitochondrionIDA
GO:0005759 mitochondrial matrixIEA
GO:0005783 endoplasmic reticulumIEA
GO:0005813 centrosomeIDA
GO:0005829 cytosolIDA
GO:0005829 cytosolTAS
GO:0016363 nuclear matrixIDA
GO:0016605 PML bodyIDA
GO:0031965 nuclear membraneIDA
GO:0032991 protein-containing complexIMP
GO:0032991 protein-containing complexIDA
GO:0035861 site of double-strand breakIEA
GO:0005669 transcription factor TFIID complexIDA
GO:0016604 nuclear bodyIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-109581 ApoptosisTAS
R-HSA-109582 HemostasisIEA
R-HSA-109606 Intrinsic Pathway for ApoptosisTAS
R-HSA-111448 Activation of NOXA and translocation to mitochondriaTAS
R-HSA-114452 Activation of BH3-only proteinsTAS
R-HSA-1257604 PIP3 activates AKT signalingTAS
R-HSA-1257604 PIP3 activates AKT signalingIEA
R-HSA-1280215 Cytokine Signaling in Immune systemTAS
R-HSA-139915 Activation of PUMA and translocation to mitochondriaTAS
R-HSA-157118 Signaling by NOTCHTAS
R-HSA-162582 Signal TransductionTAS
R-HSA-162582 Signal TransductionIEA
R-HSA-1640170 Cell CycleTAS
R-HSA-168256 Immune SystemTAS
R-HSA-1912408 Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422 Pre-NOTCH Expression and ProcessingTAS
R-HSA-212436 Generic Transcription PathwayTAS
R-HSA-2262752 Cellular responses to stressTAS
R-HSA-2559580 Oxidative Stress Induced SenescenceTAS
R-HSA-2559583 Cellular SenescenceTAS
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)TAS
R-HSA-2559585 Oncogene Induced SenescenceTAS
R-HSA-2559586 DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-2990846 SUMOylationTAS
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118 SUMOylation of transcription factorsTAS
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-3700989 Transcriptional Regulation by TP53TAS
R-HSA-390466 Chaperonin-mediated protein foldingIEA
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesisIEA
R-HSA-391251 Protein foldingIEA
R-HSA-392499 Metabolism of proteinsTAS
R-HSA-392499 Metabolism of proteinsIEA
R-HSA-449147 Signaling by InterleukinsTAS
R-HSA-453274 Mitotic G2-G2/M phasesTAS
R-HSA-5357801 Programmed Cell DeathTAS
R-HSA-5628897 TP53 Regulates Metabolic GenesTAS
R-HSA-5633007 Regulation of TP53 ActivityTAS
R-HSA-5633008 TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-5688426 DeubiquitinationTAS
R-HSA-5689880 Ub-specific processing proteasesTAS
R-HSA-5689896 Ovarian tumor domain proteasesTAS
R-HSA-5693532 DNA Double-Strand Break RepairTAS
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693606 DNA Double Strand Break ResponseTAS
R-HSA-597592 Post-translational protein modificationTAS
R-HSA-6785807 Interleukin-4 and Interleukin-13 signalingTAS
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTAS
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and LigandsTAS
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTAS
R-HSA-6804754 Regulation of TP53 ExpressionTAS
R-HSA-6804756 Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757 Regulation of TP53 DegradationTAS
R-HSA-6804758 Regulation of TP53 Activity through AcetylationTAS
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factorsTAS
R-HSA-6804760 Regulation of TP53 Activity through MethylationTAS
R-HSA-6806003 Regulation of TP53 Expression and DegradationTAS
R-HSA-6807070 PTEN RegulationTAS
R-HSA-6807070 PTEN RegulationIEA
R-HSA-6811555 PI5P Regulates TP53 AcetylationTAS
R-HSA-69275 G2/M TransitionTAS
R-HSA-69278 Cell Cycle, MitoticTAS
R-HSA-69473 G2/M DNA damage checkpointTAS
R-HSA-69481 G2/M CheckpointsTAS
R-HSA-69541 Stabilization of p53TAS
R-HSA-69560 Transcriptional activation of p53 responsive genes TAS
R-HSA-69563 p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580 p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615 G1/S DNA Damage CheckpointsTAS
R-HSA-69620 Cell Cycle CheckpointsTAS
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 TAS
R-HSA-73857 RNA Polymerase II TranscriptionTAS
R-HSA-73894 DNA RepairTAS
R-HSA-74160 Gene expression (Transcription)TAS
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8853884 Transcriptional Regulation by VENTXTAS
R-HSA-8878159 Transcriptional regulation by RUNX3TAS
R-HSA-8941855 RUNX3 regulates CDKN1A transcriptionTAS
R-HSA-8943724 Regulation of PTEN gene transcriptionTAS
R-HSA-8943724 Regulation of PTEN gene transcriptionIEA
R-HSA-8953897 Cellular responses to external stimuliTAS
R-HSA-9006925 Intracellular signaling by second messengersTAS
R-HSA-9006925 Intracellular signaling by second messengersIEA
R-HSA-983231 Factors involved in megakaryocyte development and platelet productionIEA

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0007 Acetylation
KW-0010 Activator
KW-0877 Alternative promoter usage
KW-0025 Alternative splicing
KW-0053 Apoptosis
KW-0090 Biological rhythms
KW-0131 Cell cycle
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0903 Direct protein sequencing
KW-0225 Disease mutation
KW-0238 DNA-binding
KW-0256 Endoplasmic reticulum
KW-0325 Glycoprotein
KW-0945 Host-virus interaction
KW-1017 Isopeptide bond
KW-0435 Li-Fraumeni syndrome
KW-0479 Metal-binding
KW-0488 Methylation
KW-0496 Mitochondrion
KW-1210 Necrosis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0043 Tumor suppressor
KW-0832 Ubl conjugation
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR040926 p53_TAD2
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR013872 p53_transactivation_domain
IPR002117 p53_tumour_suppressor

PROSITE

PROSITE ID PROSITE Term
PS00348 P53

Pfam

Pfam ID Pfam Term
PF00870 P53
PF08563 P53_TAD
PF07710 P53_tetramer
PF18521 TAD2

Protein-protein interaction

Protein-miRNA interaction